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This dissertation focuses on modern causal inference under uncertainty and data restrictions, with applications to neoadjuvant clinical trials, distributed data networks, and robust individualized decision making. In the first project, we…

Methodology · Statistics 2023-01-24 Xiaoqing Tan

Ensuring fairness in AI systems is critical, especially in high-stakes domains such as lending, hiring, and healthcare. This urgency is reflected in emerging global regulations that mandate fairness assessments and independent bias audits.…

Machine Learning · Computer Science 2025-08-19 Varsha Ramineni , Hossein A. Rahmani , Emine Yilmaz , David Barber

Explainable artificial intelligence (XAI) has helped elucidate the internal mechanisms of machine learning algorithms, bolstering their reliability by demonstrating the basis of their predictions. Several XAI models consider causal…

Machine Learning · Computer Science 2024-04-30 Daisuke Takahashi , Shohei Shimizu , Takuma Tanaka

Mediation analysis is a strategy for understanding the mechanisms by which treatments or interventions affect later outcomes. Mediation analysis is frequently applied in randomized trial settings, but typically assumes: a) that randomized…

Methodology · Statistics 2021-12-30 Kara E. Rudolph , Nicholas Williams , Ivan Diaz

While estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have…

Statistics Theory · Mathematics 2012-10-18 Eric J. Tchetgen Tchetgen , Ilya Shpitser

Naively trained AI models can be heavily biased. This can be particularly problematic when the biases involve legally or morally protected attributes such as ethnic background, age or gender. Existing solutions to this problem come at the…

Computer Vision and Pattern Recognition · Computer Science 2022-10-11 Nicholas Rosa , Tom Drummond , Mehrtash Harandi

The increasing usage of new data sources and machine learning (ML) technology in credit modeling raises concerns with regards to potentially unfair decision-making that rely on protected characteristics (e.g., race, sex, age) or other…

Computers and Society · Computer Science 2023-08-08 Savina Kim , Stefan Lessmann , Galina Andreeva , Michael Rovatsos

We present a method for quantitative, in-depth analyses of fairness issues in AI systems with an application to credit scoring. To this aim we use BRIO, a tool for the evaluation of AI systems with respect to social unfairness and, more in…

Mediation analysis in causal inference has traditionally focused on binary exposures and deterministic interventions, and a decomposition of the average treatment effect in terms of direct and indirect effects. In this paper we present an…

Methodology · Statistics 2020-11-17 Iván Díaz , Nima Hejazi

As AI systems become more embedded in everyday life, the development of fair and unbiased models becomes more critical. Considering the social impact of AI systems is not merely a technical challenge but a moral imperative. As evidenced in…

Machine Learning · Computer Science 2025-10-03 Aida Tayebi , Ali Khodabandeh Yalabadi , Mehdi Yazdani-Jahromi , Ozlem Ozmen Garibay

Interventional effects for mediation analysis were proposed as a solution to the lack of identifiability of natural (in)direct effects in the presence of a mediator-outcome confounder affected by exposure. We present a theoretical and…

Methodology · Statistics 2020-11-17 Iván Díaz , Nima S. Hejazi , Kara E. Rudolph , Mark J. van der Laan

Artificial intelligence (AI) systems increasingly inform medical decision-making, yet concerns about algorithmic bias and inequitable outcomes persist, particularly for historically marginalized populations. This paper introduces the…

Machine Learning · Computer Science 2025-07-22 Andrés Morales-Forero , Lili J. Rueda , Ronald Herrera , Samuel Bassetto , Eric Coatanea

A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the…

Methodology · Statistics 2023-08-31 Oliver Dukes , Ilya Shpitser , Eric J. Tchetgen Tchetgen

Academic meritocracy is jeopardized by systematic imbalances; for example, whereas Black and Hispanic individuals constitute over 30% of the U.S. population, they represent fewer than 10% of tenured academics in science and engineering.…

Computers and Society · Computer Science 2026-03-10 Uttamasha Anjally Oyshi , Gibson Nkhata , Susan Gauch

As virtually all aspects of our lives are increasingly impacted by algorithmic decision making systems, it is incumbent upon us as a society to ensure such systems do not become instruments of unfair discrimination on the basis of gender,…

Machine Learning · Computer Science 2019-03-29 Aria Khademi , Sanghack Lee , David Foley , Vasant Honavar

Machine learning (ML) models can underperform on certain population groups due to choices made during model development and bias inherent in the data. We categorize sources of discrimination in the ML pipeline into two classes: aleatoric…

Machine Learning · Computer Science 2024-04-17 Hao Wang , Luxi He , Rui Gao , Flavio P. Calmon

Algorithmic decisions about individuals require predictions that are not only accurate but also fair with respect to sensitive attributes such as gender and race. Causal notions of fairness align with legal requirements, yet many methods…

Machine Learning · Statistics 2026-03-02 Yoichi Chikahara

Fairness in artificial intelligence (AI) has become a growing concern due to discriminatory outcomes in AI-based decision-making systems. While various methods have been proposed to mitigate bias, most rely on complete demographic…

Computers and Society · Computer Science 2025-11-18 Zichong Wang , Zhipeng Yin , Roland H. C. Yap , Wenbin Zhang

Most existing methods that address out-of-distribution (OOD) generalization for node classification on graphs primarily focus on a specific type of data biases, such as label selection bias or structural bias. However, anticipating the type…

Machine Learning · Computer Science 2023-11-07 Guoxin Chen , Yongqing Wang , Fangda Guo , Qinglang Guo , Jiangli Shao , Huawei Shen , Xueqi Cheng

Causal mediation analysis decomposes the total effect of a treatment on an outcome into the indirect effect, operating through the mediator, and the direct effect, operating through other pathways. One can estimate only the pure indirect…

Applications · Statistics 2025-07-16 Vindyani Herath , Ronald J. Bosch , Judith J. Lok