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With recent advances in Large Language Models (LLMs), Agentic AI has become phenomenal in real-world applications, moving toward multiple LLM-based agents to perceive, learn, reason, and act collaboratively. These LLM-based Multi-Agent…

Artificial Intelligence · Computer Science 2025-01-14 Khanh-Tung Tran , Dung Dao , Minh-Duong Nguyen , Quoc-Viet Pham , Barry O'Sullivan , Hoang D. Nguyen

Self-evolving multi-agent systems (MAS) have emerged as a promising route to LLM agents that continually improve from experience, with persistent memory at their foundation. However, existing designs almost exclusively adopt a centralized…

Multiagent Systems · Computer Science 2026-05-22 Guangya Hao , Yunbo Long , Zhuokai Zhao

The emergence of Large Language Models (LLMs) is rapidly accelerating the development of autonomous multi-agent systems (MAS), paving the way for the Internet of Agents. However, traditional centralized MAS architectures present significant…

Multiagent Systems · Computer Science 2025-12-03 Yepeng Ding , Ahmed Twabi , Junwei Yu , Lingfeng Zhang , Tohru Kondo , Hiroyuki Sato

Multi-agent systems (MAS) built on large language models (LLMs) offer a promising path toward solving complex, real-world tasks that single-agent systems often struggle to manage. While recent advancements in test-time scaling (TTS) have…

Artificial Intelligence · Computer Science 2025-08-20 Can Jin , Hongwu Peng , Qixin Zhang , Yujin Tang , Dimitris N. Metaxas , Tong Che

Multi-Agent Systems (MAS) powered by Large Language Models (LLMs) are emerging as a powerful paradigm for solving complex, multifaceted problems. However, the potential of these systems is often constrained by the prevalent plan-and-execute…

Artificial Intelligence · Computer Science 2025-07-18 Yexuan Shi , Mingyu Wang , Yunxiang Cao , Hongjie Lai , Junjian Lan , Xin Han , Yu Wang , Jie Geng , Zhenan Li , Zihao Xia , Xiang Chen , Chen Li , Jian Xu , Wenbo Duan , Yuanshuo Zhu

In healthcare intelligence, the ability to fuse heterogeneous, multi-intent information from diverse clinical sources is fundamental to building reliable decision-making systems. Large Language Model (LLM)-driven information interaction…

Computation and Language · Computer Science 2025-07-04 Dingkang Yang , Jinjie Wei , Mingcheng Li , Jiyao Liu , Lihao Liu , Ming Hu , Junjun He , Yakun Ju , Wei Zhou , Yang Liu , Lihua Zhang

While Multi-Agent Systems (MAS) show potential for complex clinical decision support, the field remains hindered by architectural fragmentation and the lack of standardized multimodal integration. Current medical MAS research suffers from…

Artificial Intelligence · Computer Science 2026-03-20 Yunhang Qian , Xiaobin Hu , Jiaquan Yu , Siyang Xin , Xiaokun Chen , Jiangning Zhang , Peng-Tao Jiang , Jiawei Liu , Hongwei Bran Li

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

The rise of Agent AI and Large Language Model-powered Multi-Agent Systems (LLM-MAS) has underscored the need for responsible and dependable system operation. Tools like LangChain and Retrieval-Augmented Generation have expanded LLM…

Multiagent Systems · Computer Science 2025-02-05 Jinwei Hu , Yi Dong , Shuang Ao , Zhuoyun Li , Boxuan Wang , Lokesh Singh , Guangliang Cheng , Sarvapali D. Ramchurn , Xiaowei Huang

Multi-agent systems (MAS) extend large language models (LLMs) from independent single-model reasoning to coordinative system-level intelligence. While existing LLM agents depend on text-based mediation for reasoning and communication, we…

Computation and Language · Computer Science 2025-12-09 Jiaru Zou , Xiyuan Yang , Ruizhong Qiu , Gaotang Li , Katherine Tieu , Pan Lu , Ke Shen , Hanghang Tong , Yejin Choi , Jingrui He , James Zou , Mengdi Wang , Ling Yang

Large Language Models (LLMs) are increasingly deployed as reasoning systems, where reasoning paradigms - such as Chain-of-Thought (CoT) and multi-agent systems (MAS) - play a critical role, yet their relative effectiveness and cost-accuracy…

Machine Learning · Computer Science 2026-01-21 Yapeng Li , Jiakuo Yu , Zhixin Liu , Xinnan Liu , Jing Yu , Songze Li , Tonghua Su

Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure…

Artificial Intelligence · Computer Science 2025-09-30 Hongjun Liu , Yinghao Zhu , Yuhui Wang , Yitao Long , Zeyu Lai , Lequan Yu , Chen Zhao

LLM-powered Multi-Agent Systems (LLM-MAS) unlock new potentials in distributed reasoning, collaboration, and task generalization but also introduce additional risks due to unguaranteed agreement, cascading uncertainty, and adversarial…

Multiagent Systems · Computer Science 2025-10-22 Jinwei Hu , Yi Dong , Shuang Ao , Zhuoyun Li , Boxuan Wang , Lokesh Singh , Guangliang Cheng , Sarvapali D. Ramchurn , Xiaowei Huang

Large Language Model (LLM) based multi-agent systems (MAS) have shown promise in tackling complex tasks, but often rely on predefined roles and centralized coordination, limiting their adaptability to evolving challenges. This paper…

Artificial Intelligence · Computer Science 2025-09-04 Siyuan Lu , Jiaqi Shao , Bing Luo , Tao Lin

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

Accurate interpretation of clinical narratives is critical for patient care, but the complexity of these notes makes automation challenging. While Large Language Models (LLMs) show promise, single-model approaches can lack the robustness…

Artificial Intelligence · Computer Science 2025-09-01 Yeawon Lee , Xiaoyang Wang , Christopher C. Yang

Medical Decision-Making (MDM) is a multi-faceted process that requires clinicians to assess complex multi-modal patient data patient, often collaboratively. Large Language Models (LLMs) promise to streamline this process by synthesizing…

Large language models (LLMs), despite their remarkable progress across various general domains, encounter significant barriers in medicine and healthcare. This field faces unique challenges such as domain-specific terminologies and…

Computation and Language · Computer Science 2024-06-06 Xiangru Tang , Anni Zou , Zhuosheng Zhang , Ziming Li , Yilun Zhao , Xingyao Zhang , Arman Cohan , Mark Gerstein

Multi-agent systems (MAS) powered by large language models (LLMs) hold significant promise for solving complex decision-making tasks. However, the core process of collaborative decision-making (CDM) within these systems remains…

Artificial Intelligence · Computer Science 2025-08-19 Xuyang Zhao , Shiwan Zhao , Hualong Yu , Liting Zhang , Qicheng Li

Therapy recommendation for chronic patients with multimorbidity is challenging due to risks of treatment conflicts. Existing decision support systems face scalability limitations. Inspired by the way in which general practitioners (GP)…

Artificial Intelligence · Computer Science 2025-07-16 Yicong Wu , Ting Chen , Irit Hochberg , Zhoujian Sun , Ruth Edry , Zhengxing Huang , Mor Peleg
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