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Objective evaluation of quantitative imaging (QI) methods with patient data is often hindered by the lack of gold standards. To address this challenge, a class of regression-without-truth (RWT) techniques have been developed. These…

Medical Physics · Physics 2026-03-31 Yan Liu , Abhinav K. Jha

Objective evaluation of quantitative imaging (QI) methods with patient data, while important, is typically hindered by the lack of gold standards. To address this challenge, no-gold-standard evaluation (NGSE) techniques have been proposed.…

Medical Physics · Physics 2024-03-26 Yan Liu , Abhinav K. Jha

Objective evaluation of quantitative imaging (QI) methods using measurements directly obtained from patient images is highly desirable but hindered by the non-availability of gold standards. To address this issue, statistical techniques…

Methodology · Statistics 2020-06-04 Jinxin Liu , Ziping Liu , Joyce Mhlanga , Barry A. Siegel , Abhinav K. Jha

Objective evaluation of quantitative imaging (QI) methods with patient data is highly desirable, but is hindered by the lack or unreliability of an available gold standard. To address this issue, techniques that can evaluate QI methods…

Medical Physics · Physics 2022-03-07 Ziping Liu , Zekun Li , Joyce C. Mhlanga , Barry A. Siegel , Abhinav K. Jha

Quantitative imaging (QI) is demonstrating strong promise across multiple clinical applications. For clinical translation of QI methods, objective evaluation on clinically relevant tasks is essential. To address this need, multiple…

As super-resolution (SR) techniques advance, we observe a growing distrust of evaluation metrics in recent SR research. An inconsistency often emerges between certain evaluation criteria and human perceptual preference. Although current SR…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Shaolin Su , Josep M. Rocafort , Danna Xue , David Serrano-Lozano , Lei Sun , Javier Vazquez-Corral

A central obstacle in the objective assessment of treatment effect (TE) estimators in randomized control trials (RCTs) is the lack of ground truth (or validation set) to test their performance. In this paper, we propose a novel…

Objective:To develop a no-reference image quality assessment method using automated distortion recognition to boost MRI-guided radiotherapy precision.Methods:We analyzed 106,000 MR images from 10 patients with liver metastasis,captured with…

Image and Video Processing · Electrical Eng. & Systems 2024-12-11 Zilin Wang , Shengqi Chen , Jianrong Dai , Shirui Qin , Ying Cao , Ruiao Zhao , Guohua Wu , Yuan Tang , Jiayun Chen

Evaluating generative models for synthetic medical imaging is crucial yet challenging, especially given the high standards of fidelity, anatomical accuracy, and safety required for clinical applications. Standard evaluation of generated…

Image and Video Processing · Electrical Eng. & Systems 2025-05-13 Yash Deo , Yan Jia , Toni Lassila , William A. P. Smith , Tom Lawton , Siyuan Kang , Alejandro F. Frangi , Ibrahim Habli

Recent advances in quantum computers and simulators are steadily leading us towards full-scale quantum computing devices. Due to the fact that debugging is necessary to create any computing device, quantum tomography (QT) is a critical…

Quantum Physics · Physics 2021-10-12 B. I. Bantysh , A. Yu. Chernyavskiy , Yu. I. Bogdanov

Despite the increasing demand for safer machine learning practices, the use of Uncertainty Quantification (UQ) methods in production remains limited. This limitation is exacerbated by the challenge of validating UQ methods in absence of UQ…

Machine Learning · Computer Science 2025-03-03 Arthur Pignet , Chiara Regniez , John Klein

Evaluating text revision in scientific writing remains a challenge, as traditional metrics such as ROUGE and BERTScore primarily focus on similarity rather than capturing meaningful improvements. In this work, we analyse and identify the…

Computation and Language · Computer Science 2026-01-26 Léane Jourdan , Florian Boudin , Richard Dufour , Nicolas Hernandez

Real-World Data (RWD), with its large sample sizes and rich clinical detail, offers a compelling alternative to randomized controlled trials (RCTs) for studying treatment effects in diverse and complex patient populations. However, its…

Applications · Statistics 2026-05-26 Yifei Xu , Hwiyoung Lee , Zhenyao Ye , Yezhi Pan , Jingsong Zhou , Yun Yang , Chixiang Chen , Shuo Chen

Dichotomous diagnostic tests are widely used to detect the presence or absence of a biomedical condition of interest. A rigorous evaluation of the accuracy of a diagnostic test is critical to determine its practical value. Performance…

Applications · Statistics 2016-09-22 Ana Subtil , Maria Rosário Oliveira , António Pacheco

One major problem of objective Image Quality Assessment (IQA) methods is the lack of linearity of their quality estimates with respect to scores expressed by human subjects. For this reason, usually IQA metrics undergo a calibration process…

Computer Vision and Pattern Recognition · Computer Science 2022-05-25 Elio D. Di Claudio , Paolo Giannitrapani , Giovanni Jacovitti

Over the last few years, debiased estimators have been proposed in order to establish rigorous confidence intervals for high-dimensional problems in machine learning and data science. The core argument is that the error of these estimators…

Signal Processing · Electrical Eng. & Systems 2024-07-19 Frederik Hoppe , Claudio Mayrink Verdun , Felix Krahmer , Marion I. Menzel , Holger Rauhut

We introduce a novel cross-reference image quality assessment method that effectively fills the gap in the image assessment landscape, complementing the array of established evaluation schemes -- ranging from full-reference metrics like…

Computer Vision and Pattern Recognition · Computer Science 2024-07-24 Zirui Wang , Wenjing Bian , Victor Adrian Prisacariu

Purpose: Reliable image quality assessment is crucial for evaluating new motion correction methods for magnetic resonance imaging. In this work, we compare the performance of commonly used reference-based and reference-free image quality…

Medical Physics · Physics 2025-06-18 Elisa Marchetto , Hannah Eichhorn , Daniel Gallichan , Julia A. Schnabel , Melanie Ganz

We present a generic method for assessing the quality of non-rigid registration (NRR) algorithms, that does not depend on the existence of any ground truth, but depends solely on the data itself. The data is a set of images. The output of…

Computer Vision and Pattern Recognition · Computer Science 2020-02-26 Carole J. Twining , Vladimir S. Petrović , Timothy F. Cootes , Roy S. Schestowitz , William R. Crum , Christopher J. Taylor

Generating high-quality synthetic data is crucial for addressing challenges in medical imaging, such as domain adaptation, data scarcity, and privacy concerns. Existing image quality metrics often rely on reference images, are tailored for…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Karl Van Eeden Risager , Torkan Gholamalizadeh , Mostafa Mehdipour Ghazi
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