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For mental disorders, patients' underlying mental states are non-observed latent constructs which have to be inferred from observed multi-domain measurements such as diagnostic symptoms and patient functioning scores. Additionally,…

Machine Learning · Computer Science 2020-11-03 Yuan Chen , Donglin Zeng , Tianchen Xu , Yuanjia Wang

Inferring causal individual treatment effect (ITE) from observational data is a challenging problem whose difficulty is exacerbated by the presence of treatment assignment bias. In this work, we propose a new way to estimate the ITE using…

Machine Learning · Computer Science 2021-03-16 Abhin Shah , Kartik Ahuja , Karthikeyan Shanmugam , Dennis Wei , Kush Varshney , Amit Dhurandhar

Large Language Models (LLMs) have shown superior performance in various applications and fields. To achieve better performance on specialized domains such as law and advertisement, LLMs are often continue pre-trained on in-domain data.…

Computation and Language · Computer Science 2024-06-25 Xiao Liang , Xinyu Hu , Simiao Zuo , Yeyun Gong , Qiang Lou , Yi Liu , Shao-Lun Huang , Jian Jiao

Estimating individualised treatment effect (ITE) -- that is the causal effect of a set of variables (also called exposures, treatments, actions, policies, or interventions), referred to as \textit{composite treatments}, on a set of outcome…

Machine Learning · Computer Science 2025-12-19 Vinod Kumar Chauhan , Lei Clifton , Gaurav Nigam , David A. Clifton

Data-driven individualized decision making has recently received increasing research interests. Most existing methods rely on the assumption of no unmeasured confounding, which unfortunately cannot be ensured in practice especially in…

Methodology · Statistics 2022-12-26 Zhengling Qi , Rui Miao , Xiaoke Zhang

Understanding cognitive processes in major depressive disorder (MDD) often relies on behavioral tasks, which are typically analyzed separately, overlooking potential correlations and shared latent structure. To address this limitation, we…

Methodology · Statistics 2026-05-26 Yuan Bian , Yuanjia Wang , Xingche Guo

Estimation of individualized treatment effects (ITE) from observational studies is a fundamental problem in causal inference and holds significant importance across domains, including healthcare. However, limited observational datasets pose…

Machine Learning · Computer Science 2024-02-14 Vinod Kumar Chauhan , Jiandong Zhou , Ghadeer Ghosheh , Soheila Molaei , David A. Clifton

Recent development in the data-driven decision science has seen great advances in individualized decision making. Given data with individual covariates, treatment assignments and outcomes, policy makers best individualized treatment rule…

Machine Learning · Statistics 2020-06-29 Weibin Mo , Zhengling Qi , Yufeng Liu

Multimodal large language models (MLLMs) have made rapid progress, yet their reasoning ability often lags behind strong text-only LLMs. Bridging this gap typically requires large-scale multimodal reasoning data or reinforcement learning,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Chao Huang , Zeliang Zhang , Jiang Liu , Ximeng Sun , Jialian Wu , Xiaodong Yu , Ze Wang , Chenliang Xu , Emad Barsoum , Zicheng Liu

Modern deep learning architectures excel at optimization, but only after the data has entered the network. The true bottleneck lies in preparing the right input: minimal, salient, and structured in a way that reflects the essential patterns…

Machine Learning · Computer Science 2025-06-25 Ben Keslaki

There is intense interest in applying machine learning to problems of causal inference in fields such as healthcare, economics and education. In particular, individual-level causal inference has important applications such as precision…

Machine Learning · Statistics 2017-05-17 Uri Shalit , Fredrik D. Johansson , David Sontag

Modern treatment targeting methods often rely on estimating the conditional average treatment effect (CATE) using machine learning tools. While effective in identifying who benefits from treatment on the individual level, these approaches…

Methodology · Statistics 2025-11-05 Yuchen Hu , Shuangning Li , Stefan Wager

Deep neural networks remain highly vulnerable to adversarial examples, and most defenses collapse once gradients can be reliably estimated. We identify \emph{gradient consensus} -- the tendency of randomized transformations to yield aligned…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Amira Guesmi , Muhammad Shafique

Real-world large language model deployments (e.g., conversational AI systems, code generation assistants) naturally generate abundant implicit user dissatisfaction (DSAT) signals, as users iterate toward better answers through refinements,…

Computation and Language · Computer Science 2026-02-03 Yifan Wang , Bolian Li , Junlin Wu , Zhaoxuan Tan , Zheli Liu , Ruqi Zhang , Ananth Grama , Qingkai Zeng

Dynamic treatment regimes are sequential decision rules that adapt treatment according to individual time-varying characteristics and outcomes to achieve optimal effects, with applications in precision medicine, personalized…

Methodology · Statistics 2025-10-24 Yuanshan Gao , Yang Bai , Yifan Cui

We propose to meta-learn an a self-supervised patient trajectory forecast learning rule by meta-training on a meta-objective that directly optimizes the utility of the patient representation over the subsequent clinical outcome prediction.…

Machine Learning · Computer Science 2024-07-30 Yuan Xue , Nan Du , Anne Mottram , Martin Seneviratne , Andrew M. Dai

A core component of precision medicine research involves optimizing individualized treatment rules (ITRs) based on patient characteristics. Many studies used to estimate ITRs are longitudinal in nature, collecting outcomes over time. Yet,…

Methodology · Statistics 2024-05-29 Lanqiu Yao , Thaddeus Tarpey

In recent years, precision treatment strategy have gained significant attention in medical research, particularly for patient care. We propose a novel framework for estimating conditional average treatment effects (CATE) in time-to-event…

Methodology · Statistics 2024-07-29 Runjia Li , Victor B. Talisa , Chung-Chou H. Chang

The ability to predict individualized treatment effects (ITEs) based on a given patient's profile is essential for personalized medicine. We propose a hypothesis testing approach to choosing between two potential treatments for a given…

Methodology · Statistics 2020-08-11 Tianxi Cai , Tony Cai , Zijian Guo

Interpretable Learning to Rank (LtR) is an emerging field within the research area of explainable AI, aiming at developing intelligible and accurate predictive models. While most of the previous research efforts focus on creating post-hoc…

Information Retrieval · Computer Science 2022-06-02 Claudio Lucchese , Franco Maria Nardini , Salvatore Orlando , Raffaele Perego , Alberto Veneri
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