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Personalized chronic care requires the integration of multimodal health data to enable precise, adaptive, and preventive decision-making. Yet most current digital twin (DT) applications remain organ-specific or tied to isolated data types,…

Software Engineering · Computer Science 2025-10-13 Amal Elgammal , Bernd J. Krämer , Michael P. Papazoglou , Mira Raheem

Efficient digital twin (DT) synchronization relies on maintaining high-fidelity virtual representations with minimal age of information (AoI). However, the synergistic potential of cooperative sensing and autonomous mobility of the sensing…

With the continued growth of its core technologies, including the Internet of Things (IoT), artificial intelligence (AI), Big Data and data analytics, and edge computing, digital twin (DT) technology has witnessed a significant increase in…

Emerging Technologies · Computer Science 2025-04-23 Ghofran Khalaf , May Itani , Sanaa Sharafeddine

Digital twin (DT) technology enables real-time simulation, prediction, and optimization of physical systems, but practical deployment faces challenges from high data requirements, proprietary data constraints, and limited adaptability to…

Cognitive decline is highly heterogeneous across individuals, which complicates prognosis, trial design, and treatment planning. We present the Personalized Cognitive Decline Assessment Digital Twin (PCD-DT), a multimodal and…

Artificial Intelligence · Computer Science 2026-05-01 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

Static solutions don't serve a dynamic mind. Thus, we advocate a shift from static mental health diagnostic assessments to continuous, artificial intelligence (AI)-driven assessment. Focusing on Attention-Deficit/Hyperactivity Disorder…

Artificial Intelligence · Computer Science 2025-10-10 Neil Natarajan , Sruthi Viswanathan , Xavier Roberts-Gaal , Michelle Marie Martel

Autonomous driving systems continue to face safety-critical failures, often triggered by rare and unpredictable corner cases that evade conventional testing. We present the Autonomous Driving Digital Twin (ADDT) framework, a high-fidelity…

Robotics · Computer Science 2025-04-15 Bo Yu , Chaoran Yuan , Zishen Wan , Jie Tang , Fadi Kurdahi , Shaoshan Liu

We introduce EdgeAgentX-DT, an advanced extension of the EdgeAgentX framework that integrates digital twin simulations and generative AI-driven scenario training to significantly enhance edge intelligence in military networks. EdgeAgentX-DT…

Machine Learning · Computer Science 2025-07-30 Abir Ray

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models…

Machine Learning · Computer Science 2025-05-01 Gulsah Hancerliogullari Koksalmis , Bulent Soykan , Laura J. Brattain , Hsin-Hsiung Huang

Human digital twins (HDTs) are dynamic, data-driven virtual representations of individuals, continuously updated with multimodal data to simulate, monitor, and predict health trajectories. By integrating clinical, physiological, behavioral,…

Human-Computer Interaction · Computer Science 2025-08-19 Rong Pan , Hongyue Sun , Xiaoyu Chen , Giulia Pedrielli , Jiapeng Huang

Anomaly detection techniques enable effective anomaly detection and diagnosis in multi-variate time series data, which are of major significance for today's industrial applications. However, establishing an anomaly detection system that can…

Machine Learning · Computer Science 2024-05-02 Lingrui Yu

Datacenters are the backbone of our digital society, but raise numerous operational challenges. We envision digital twins becoming primary instruments in datacenter operations, continuously and autonomously helping with major operational…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-14 Radu Nicolae , Jules van der Toorn , Stavriana Kraniti , Houcen Liu , Alexandru Iosup

Deep learning models define the state-of-the-art in Automatic Drum Transcription (ADT), yet their performance is contingent upon large-scale, paired audio-MIDI datasets, which are scarce. Existing workarounds that use synthetic data often…

Sound · Computer Science 2026-01-15 Pierfrancesco Melucci , Paolo Merialdo , Taketo Akama

Generative artificial intelligence (GAI) and digital twin (DT) are advanced data processing and virtualization technologies to revolutionize communication networks. Thanks to the powerful data processing capabilities of GAI, integrating it…

Networking and Internet Architecture · Computer Science 2024-04-09 Xinyu Huang , Haojun Yang , Conghao Zhou , Mingcheng He , Xuemin Shen , Weihua Zhuang

With the accelerating availability of multimodal surgical data and real-time computation, Surgical Digital Twins (SDTs) have emerged as virtual counterparts that mirror, predict, and inform decisions across pre-, intra-, and postoperative…

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

The development of large language models (LLM) has revolutionized various fields and is anticipated to drive the advancement of autonomous systems. In the context of autonomous optical networks, creating a high-level cognitive agent in the…

Networking and Internet Architecture · Computer Science 2024-11-04 Yuchen Song , Yao Zhang , Anni Zhou , Yan Shi , Shikui Shen , Xiongyan Tang , Jin Li , Min Zhang , Danshi Wang

Digital Twins (DTs) are computational models that simulate the states and temporal dynamics of real-world systems, playing a crucial role in prediction, understanding, and decision-making across diverse domains. However, existing approaches…

Machine Learning · Computer Science 2024-11-01 Samuel Holt , Tennison Liu , Mihaela van der Schaar

Artificial Intelligence (AI) and Large Language Models (LLMs) hold significant promise in revolutionizing healthcare, especially in clinical applications. Simultaneously, Digital Twin technology, which models and simulates complex systems,…

Artificial Intelligence · Computer Science 2024-09-27 Himanshu Pandey , Akhil Amod , Shivang , Kshitij Jaggi , Ruchi Garg , Abheet Jain , Vinayak Tantia

Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…

Machine Learning · Computer Science 2025-09-16 Rumeng Li , Xun Wang , Hong Yu
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