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Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

Genomics · Quantitative Biology 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Object categories inherently form a hierarchy with different levels of concept abstraction, especially for fine-grained categories. For example, birds (Aves) can be categorized according to a four-level hierarchy of order, family, genus,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-15 Tianshui Chen , Wenxi Wu , Yuefang Gao , Le Dong , Xiaonan Luo , Liang Lin

Attribute recognition is a crucial but challenging task due to viewpoint changes, illumination variations and appearance diversities, etc. Most of previous work only consider the attribute-level feature embedding, which might perform poorly…

Computer Vision and Pattern Recognition · Computer Science 2020-05-26 Jie Yang , Jiarou Fan , Yiru Wang , Yige Wang , Weihao Gan , Lin Liu , Wei Wu

Single-cell RNA sequencing (scRNA-seq) is powerful technology that allows researchers to understand gene expression patterns at the single-cell level. However, analysing scRNA-seq data is challenging due to issues and biases in data…

Genomics · Quantitative Biology 2023-12-14 Jinlu Liu , Sara Wade , Natalia Bochkina

State-of-the-art two-stage object detectors apply a classifier to a sparse set of object proposals, relying on region-wise features extracted by RoIPool or RoIAlign as inputs. The region-wise features, in spite of aligning well with the…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Zhao-Min Chen , Xin Jin , Borui Zhao , Xiu-Shen Wei , Yanwen Guo

Heterogeneous graphs, whose nodes and edges can belong to different types and feature spaces, arise in many real-world domains, including biology, recommendation, social networks, and computer systems. Existing heterogeneous graph neural…

In recent years, hyperspectral imaging, also known as imaging spectroscopy, has been paid an increasing interest in geoscience and remote sensing community. Hyperspectral imagery is characterized by very rich spectral information, which…

Computer Vision and Pattern Recognition · Computer Science 2020-07-20 Danfeng Hong , Jing Yao , Xin Wu , Jocelyn Chanussot , Xiao Xiang Zhu

We propose a novel method, scTree, for single-cell Tree Variational Autoencoders, extending a hierarchical clustering approach to single-cell RNA sequencing data. scTree corrects for batch effects while simultaneously learning a…

Machine Learning · Computer Science 2024-07-11 Moritz Vandenhirtz , Florian Barkmann , Laura Manduchi , Julia E. Vogt , Valentina Boeva

In single-cell research, tracing and analyzing high-throughput single-cell differentiation trajectories is crucial for understanding biological processes. Key to this is the robust modeling of hierarchical structures that govern cellular…

Machine Learning · Computer Science 2026-05-19 Zelin Zang , WenZhe Li , Yongjie Xu , Chang Yu , Changxi Chi , Jingbo Zhou , Zhen Lei , Stan Z. Li

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

Dynamic relational data arise in many machine learning applications, yet their evolving structure poses challenges for learning representations that remain consistent and interpretable over time. A common approach is to learn time varying…

Machine Learning · Statistics 2026-05-05 Haruka Ezoe , Hiroki Matsumoto , Ryohei Hisano

Single-cell data analysis seeks to characterize cellular heterogeneity based on high-dimensional gene expression profiles. Conventional approaches represent each cell as a vector in Euclidean space, which limits their ability to capture…

Machine Learning · Computer Science 2025-11-18 Xiang Xiang Wang , Sean Cottrell , Guo-Wei Wei

Graph-based semi-supervised learning methods, which deal well with the situation of limited labeled data, have shown dominant performance in practical applications. However, the high dimensionality of hyperspectral images (HSI) makes it…

Computer Vision and Pattern Recognition · Computer Science 2021-03-26 Yanling Miao , Qi Wang , Mulin Chen , Xuelong Li

In Magnetic Resonance Fingerprinting (MRF) the quality of the estimated parameter maps depends on the encoding capability of the variable flip angle train. In this work we show how the dimensionality reduction technique Hierarchical…

Image and Video Processing · Electrical Eng. & Systems 2019-10-08 Kirsten Koolstra , Peter Börnert , Boudewijn Lelieveldt , Andrew Webb , Oleh Dzyubachyk

Motivation: Single cell RNA sequencing (scRNA-seq) data makes studying the development of cells possible at unparalleled resolution. Given that many cellular differentiation processes are hierarchical, their scRNA-seq data is expected to be…

Quantitative Methods · Quantitative Biology 2022-04-25 Quentin Garrido , Sebastian Damrich , Alexander Jäger , Dario Cerletti , Manfred Claassen , Laurent Najman , Fred Hamprecht

Biomolecular graph analysis has recently gained much attention in the emerging field of geometric deep learning. Here we focus on organizing biomolecular graphs in ways that expose meaningful relations and variations between them. We…

Machine Learning · Computer Science 2022-03-29 Egbert Castro , Andrew Benz , Alexander Tong , Guy Wolf , Smita Krishnaswamy

Many structured systems admit locally consistent descriptions that nevertheless fail to globalize when constrained by an ambient reference or feasibility condition. Diagnosing such failures is naturally an evaluative problem: given a fixed…

Algebraic Topology · Mathematics 2026-02-05 Shinobu Yokoyama

Single-cell RNA sequencing (scRNA-seq) has made significant strides in unraveling the intricate cellular diversity within complex tissues. This is particularly critical in the brain, presenting a greater diversity of cell types than other…

Machine Learning · Computer Science 2023-10-05 Gyutaek Oh , Baekgyu Choi , Inkyung Jung , Jong Chul Ye

Stochastic neighbor embedding (SNE) and related nonlinear manifold learning algorithms achieve high-quality low-dimensional representations of similarity data, but are notoriously slow to train. We propose a generic formulation of embedding…

Machine Learning · Computer Science 2012-06-22 Max Vladymyrov , Miguel Carreira-Perpinan

Deep learning has become increasingly important in remote sensing image classification due to its ability to extract semantic information from complex data. Classification tasks often include predefined label hierarchies that represent the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Giulio Weikmann , Gianmarco Perantoni , Lorenzo Bruzzone
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