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Evaluation of artificial intelligence (AI) models for low-dose CT lung cancer screening is limited by heterogeneous datasets, annotation standards, and evaluation protocols, making performance difficult to compare and translate across…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Fakrul Islam Tushar , Avivah Wang , Lavsen Dahal , Ehsan Samei , Michael R. Harowicz , Jayashree Kalpathy-Cramer , Kyle J. Lafata , Tina D. Tailor , Cynthia Rudin , Joseph Y. Lo

Background: Sensitivity of AI-assisted lung nodule detection systems is known to vary with CT acquisition parameters including radiation dose, reconstruction kernel, and slice thickness. However, the dependence of detection probability on…

Image and Video Processing · Electrical Eng. & Systems 2026-05-05 Dan Soliman

Lung cancer is a primary contributor to cancer-related mortality globally, highlighting the necessity for precise early detection of pulmonary nodules through low-dose CT (LDCT) imaging. Deep learning methods have improved nodule detection…

Quantitative Methods · Quantitative Biology 2025-12-10 Fateme Mobini , Mohammad Reza Hedyehzadeh , Mahdi Yousefi

Early detection of malignant lung nodules remains constrained by size and growth based screening criteria, often delaying diagnosis. We present an integrated AI system that jointly performs nodule detection and malignancy assessment…

A main barrier for the deployment of AI radiomic systems in clinical routine is their drop in performance under heterogeneous multicentre acquisition protocols. This work presents a performance-oriented framework for quantifying scan…

Artificial Intelligence · Computer Science 2026-05-15 D. Gil , I. Sanchez , C. Sanchez

Detecting malignant pulmonary nodules at an early stage can allow medical interventions which may increase the survival rate of lung cancer patients. Using computer vision techniques to detect nodules can improve the sensitivity and the…

Image and Video Processing · Electrical Eng. & Systems 2020-10-30 Siqi Liu , Arnaud Arindra Adiyoso Setio , Florin C. Ghesu , Eli Gibson , Sasa Grbic , Bogdan Georgescu , Dorin Comaniciu

Objectives: To compare artificial intelligence (AI) as a second reader in detecting lung nodules on chest X-rays (CXR) versus radiologists of two binational institutions, and to evaluate AI performance when using two different modes:…

Low-dose computed tomography (LDCT) is the standard modality for lung cancer screening, known for its low radiation dose but high noise levels. While existing literature focuses on denoising LDCT images, comparative research on simulating…

Image and Video Processing · Electrical Eng. & Systems 2026-05-13 Jiaying Liu , Anna Corti , Valentina D. A. Corino , Luca Mainardi

Objective: In clinical practice, small lung nodules can be easily overlooked by radiologists. The paper aims to provide an efficient and accurate detection system for small lung nodules while keeping good performance for large nodules.…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Sunyi Zheng , Ludo J. Cornelissen , Xiaonan Cui , Xueping Jing , Raymond N. J. Veldhuis , Matthijs Oudkerk , Peter M. A. van Ooijen

Objective: Although medical imaging datasets are increasingly available, abnormal and annotation-intensive findings critical to lung cancer screening, particularly small pulmonary nodules, remain underrepresented and inconsistently curated.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Fakrul Islam Tushar , Ehsan Samei , Cynthia Rudin , Joseph Y. Lo

Consistency and duplicability in Computed Tomography (CT) output is essential to quantitative imaging for lung cancer detection and monitoring. This study of CT-detected lung nodules investigated the reproducibility of volume-, density-,…

The 3D simulation model of the lung was established by using the reconstruction method. A computer aided pulmonary nodule detection model was constructed. The process iterates over the images to refine the lung nodule recognition model…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Yutian Yang , Hongjie Qiu , Yulu Gong , Xiaoyi Liu , Yang Lin , Muqing Li

Accurate detection of pulmonary nodules with high sensitivity and specificity is essential for automatic lung cancer diagnosis from CT scans. Although many deep learning-based algorithms make great progress for improving the accuracy of…

Image and Video Processing · Electrical Eng. & Systems 2019-07-30 Jingya Liu , Liangliang Cao , Oguz Akin , Yingli Tian

Background: AI-based classification models are essential for improving lung cancer diagnosis. However, the relative performance of lesion-level versus chest-region models in internal and external datasets remains unclear. Purpose: This…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Fakrul Islam Tushar

Lung cancer is the second most common cancer and the leading cause of cancer-related deaths worldwide. Survival largely depends on tumor stage at diagnosis, and early detection with low-dose CT can significantly reduce mortality in…

We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Onur Ozdemir , Rebecca L. Russell , Andrew A. Berlin

Recently, lung nodule detection methods based on deep learning have shown excellent performance in the medical image processing field. Considering that only a few public lung datasets are available and lung nodules are more difficult to…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Yujiang Chen , Mei Xie

Purpose: Lung nodules have very diverse shapes and sizes, which makes classifying them as benign/malignant a challenging problem. In this paper, we propose a novel method to predict the malignancy of nodules that have the capability to…

Computer Vision and Pattern Recognition · Computer Science 2019-04-24 Mundher Al-Shabi , Boon Leong Lan , Wai Yee Chan , Kwan-Hoong Ng , Maxine Tan

Importance: Coronary algorithm for cardiac sub structures and prospective real-time surveillance of cardiac dose exposure. Methods: Retro and prospective study to validate AI auto-segmentation. A 3D UNet was trained on 560 thoracic CT scans…

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