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Generative modeling of single-cell RNA-seq data is crucial for tasks like trajectory inference, batch effect removal, and simulation of realistic cellular data. However, recent deep generative models simulating synthetic single cells from…

Quantitative Methods · Quantitative Biology 2025-03-04 Alessandro Palma , Till Richter , Hanyi Zhang , Manuel Lubetzki , Alexander Tong , Andrea Dittadi , Fabian Theis

Dynamic total body positron emission tomography (TB-PET) makes it feasible to measure the kinetics of all organs in the body simultaneously which may lead to important applications in multi-organ disease and systems physiology. Since…

Medical Physics · Physics 2026-01-14 Yun Zhao , Qinlin Gu , Georgios I. Angelis , Andrew J. Reader , Yanan Fan , Steven R. Meikle

Submodular maximization under matroid constraints is a fundamental problem in combinatorial optimization with applications in sensing, data summarization, active learning, and resource allocation. While the Sequential Greedy (SG) algorithm…

Machine Learning · Computer Science 2026-05-20 Mohammadreza Rostami , Solmaz S. Kia

Generative Adversarial Networks (GANs) are proficient at generating synthetic data but continue to suffer from mode collapse, where the generator produces a narrow range of outputs that fool the discriminator but fail to capture the full…

Machine Learning · Computer Science 2025-11-03 Mahsa Valizadeh , Rui Tuo , James Caverlee

Affective computing faces a major challenge: the lack of high-quality, diverse depth facial datasets for recognizing subtle emotional expressions. We propose a framework for synthetic depth face generation using an optimized GAN with…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Seyed Muhammad Hossein Mousavi , S. Younes Mirinezhad

Electrocardiography (ECG) is a non-invasive tool for predicting cardiovascular diseases (CVDs). Current ECG-based diagnosis systems show promising performance owing to the rapid development of deep learning techniques. However, the label…

Signal Processing · Electrical Eng. & Systems 2023-06-21 Rushuang Zhou , Lei Lu , Zijun Liu , Ting Xiang , Zhen Liang , David A. Clifton , Yining Dong , Yuan-Ting Zhang

Large-scale demonstration data has powered key breakthroughs in robot manipulation, but collecting that data remains costly and time-consuming. We present Constraint-Preserving Data Generation (CP-Gen), a method that uses a single expert…

Robotics · Computer Science 2025-08-07 Kevin Lin , Varun Ragunath , Andrew McAlinden , Aaditya Prasad , Jimmy Wu , Yuke Zhu , Jeannette Bohg

Generative models such as the variational autoencoder (VAE) and the generative adversarial networks (GAN) have proven to be incredibly powerful for the generation of synthetic data that preserves statistical properties and utility of…

Signal Processing · Electrical Eng. & Systems 2022-04-29 Moustafa Alzantot , Luis Garcia , Mani Srivastava

Combining multiple audio features can improve the performance of music tagging, but common deep learning-based feature fusion methods often lack interpretability. To address this problem, we propose a Genetic Programming (GP) pipeline that…

Processing temporal sequences is central to a variety of applications in health care, and in particular multi-channel Electrocardiogram (ECG) is a highly prevalent diagnostic modality that relies on robust sequence modeling. While Recurrent…

Machine Learning · Statistics 2018-07-17 Deepta Rajan , Jayaraman J. Thiagarajan

Accelerated Cardiovascular Magnetic Resonance (CMR) image reconstruction remains a critical challenge due to the trade-off between scan time and image quality, particularly when generalizing across diverse acquisition settings. We propose…

Image and Video Processing · Electrical Eng. & Systems 2025-10-30 Kian Anvari Hamedani , Narges Razizadeh , Shahabedin Nabavi , Mohsen Ebrahimi Moghaddam

Coarse-graining (CG) of molecular simulations simplifies the particle representation by grouping selected atoms into pseudo-beads and drastically accelerates simulation. However, such CG procedure induces information losses, which makes…

Machine Learning · Computer Science 2022-06-20 Wujie Wang , Minkai Xu , Chen Cai , Benjamin Kurt Miller , Tess Smidt , Yusu Wang , Jian Tang , Rafael Gómez-Bombarelli

Electrocardiogram (ECG) data collection during emergency situations is challenging, making ECG data generation an efficient solution for dealing with highly imbalanced ECG training datasets. In this paper, we propose a novel approach for…

Signal Processing · Electrical Eng. & Systems 2023-06-06 Nour Neifar , Achraf Ben-Hamadou , Afef Mdhaffar , Mohamed Jmaiel , Bernd Freisleben

Graph generation is a crucial task in many fields, including network science and bioinformatics, as it enables the creation of synthetic graphs that mimic the properties of real-world networks for various applications. Graph Generative…

Machine Learning · Computer Science 2026-01-21 Salvatore Romano , Marco Grassia , Giuseppe Mangioni

Although Multimodal Large Language Models (MLLMs) have advanced rapidly, they still face notable challenges in fine-grained multi-image understanding, often exhibiting spatial hallucination, attention leakage, and failures in object…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Lihao Zheng , Zhenwei Shao , Yu Zhou , Yan Yang , Xintian Shen , Jiawei Chen , Hao Ma , Tao Wei

Generating synthetic ECG data has numerous applications in healthcare, from educational purposes to simulating scenarios and forecasting trends. While recent diffusion models excel at generating short ECG segments, they struggle with longer…

Signal Processing · Electrical Eng. & Systems 2025-05-27 Paul Pöhl , Viktor Schlegel , Hao Li , Anil Bharath

Real-world multimodal knowledge graphs (MMKGs) are dynamic, with new entities, relations, and multimodal knowledge emerging over time. Existing continual knowledge graph reasoning (CKGR) methods focus on structural triples and cannot fully…

Computation and Language · Computer Science 2026-04-06 Linyu Li , Zhi Jin , Yichi Zhang , Dongming Jin , Yuanpeng He , Haoran Duan , Gadeng Luosang , Nyima Tashi

Gait analysis is crucial for the diagnosis and monitoring of movement disorders like Parkinson's Disease. While computer vision models have shown potential for objectively evaluating parkinsonian gait, their effectiveness is limited by…

Computer Vision and Pattern Recognition · Computer Science 2025-11-13 Vida Adeli , Soroush Mehraban , Majid Mirmehdi , Alan Whone , Benjamin Filtjens , Amirhossein Dadashzadeh , Alfonso Fasano , Andrea Iaboni , Babak Taati

Within cardiovascular disease detection using deep learning applied to ECG signals, the complexities of handling physiological signals have sparked growing interest in leveraging deep generative models for effective data augmentation. In…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Nour Neifar , Achraf Ben-Hamadou , Afef Mdhaffar , Mohamed Jmaiel

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

Machine Learning · Computer Science 2026-03-31 Qian Shao , Bang Du , Zepeng Li , Qiyuan Chen , Jiahe Chen , Hongxia Xu , Jimeng Sun , Jian Wu , Jintai Chen