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How can we draw trustworthy scientific conclusions? One criterion is that a study can be replicated by independent teams. While replication is critically important, it is arguably insufficient. If a study is biased for some reason and other…

Methodology · Statistics 2025-02-06 Yujin Jeong , Dominik Rothenhäusler

Estimating uncertainty of machine learning models is essential to assess the quality of the predictions that these models provide. However, there are several factors that influence the quality of uncertainty estimates, one of which is the…

Machine Learning · Computer Science 2022-11-03 Yuko Kato , David M. J. Tax , Marco Loog

Mathematical models of complex social systems can enrich social scientific theory, inform interventions, and shape policy. From voting behavior to economic inequality and urban development, such models influence decisions that affect…

Model editing has become an increasingly popular alternative for efficiently updating knowledge within language models. Current methods mainly focus on reliability, generalization, and locality, with many methods excelling across these…

Artificial Intelligence · Computer Science 2024-10-25 Qi Li , Xiang Liu , Zhenheng Tang , Peijie Dong , Zeyu Li , Xinglin Pan , Xiaowen Chu

The search for a scientific theory of consciousness should result in theories that are falsifiable. However, here we show that falsification is especially problematic for theories of consciousness. We formally describe the standard…

Neurons and Cognition · Quantitative Biology 2021-04-29 Johannes Kleiner , Erik Hoel

The ubiquity of machine learning based predictive models in modern society naturally leads people to ask how trustworthy those models are? In predictive modeling, it is quite common to induce a trade-off between accuracy and…

Machine Learning · Computer Science 2019-04-05 John Mitros , Brian Mac Namee

The unparalleled success of artificial intelligence (AI) in the technology sector has catalyzed an enormous amount of research in the scientific community. It has proven to be a powerful tool, but as with any rapidly developing field, the…

Machine Learning · Computer Science 2022-10-07 M. R. Carbone

Hypothesis formulation and testing are central to empirical research. A strong hypothesis is a best guess based on existing evidence and informed by a comprehensive view of relevant literature. However, with exponential increase in the…

Computation and Language · Computer Science 2024-03-27 Sai Koneru , Jian Wu , Sarah Rajtmajer

The diverse views of science of security have opened up several alleys towards applying the methods of science to security. We pursue a different kind of connection between science and security. This paper explores the idea that security is…

Cryptography and Security · Computer Science 2015-04-23 Dusko Pavlovic

Cognitive science faces ongoing challenges in research integration, formalization, conceptual clarity, and other areas, in part due to its multifaceted and interdisciplinary nature. Recent advances in artificial intelligence, particularly…

Artificial Intelligence · Computer Science 2026-03-03 Dirk U. Wulff , Rui Mata

Our intention is to provide a definitive reference on what it would take to safely make use of generative/predictive models in the absence of a solution to the Eliciting Latent Knowledge problem. Furthermore, we believe that large language…

Artificial Intelligence · Computer Science 2023-02-07 Evan Hubinger , Adam Jermyn , Johannes Treutlein , Rubi Hudson , Kate Woolverton

CONTEXT: There is growing interest in establishing software engineering as an evidence-based discipline. To that end, replication is often used to gain confidence in empirical findings, as opposed to reproduction where the goal is showing…

Software Engineering · Computer Science 2018-02-14 Martin Shepperd

Increasing model size has unlocked a dazzling array of capabilities in modern language models. At the same time, even frontier models remain vulnerable to jailbreaks and prompt injections, despite concerted efforts to make them robust. As…

Machine Learning · Computer Science 2025-06-06 Nikolaus Howe , Ian McKenzie , Oskar Hollinsworth , Michał Zajac , Tom Tseng , Aaron Tucker , Pierre-Luc Bacon , Adam Gleave

Modern science increasingly relies on ever-growing observational datasets and automated inference pipelines, under the implicit belief that accumulating more data makes scientific conclusions more reliable. Here we show that this belief can…

Machine Learning · Computer Science 2026-02-06 Zhipeng Zhang , Kai Li

Leakage of data from publicly available Machine Learning (ML) models is an area of growing significance as commercial and government applications of ML can draw on multiple sources of data, potentially including users' and clients'…

There is significant interest in using modern neural networks for scientific applications due to their effectiveness in modeling highly complex, non-linear problems in a data-driven fashion. However, a common challenge is to verify the…

Computational Physics · Physics 2019-10-07 Rushil Anirudh , Jayaraman J. Thiagarajan , Shusen Liu , Peer-Timo Bremer , Brian K. Spears

We analyze different types of simulations that applied researchers can use to assess whether their inference methods reliably control false-positive rates. We show that different assessments involve trade-offs, varying in the types of…

Econometrics · Economics 2025-10-03 Bruno Ferman

Deep neural networks have demonstrated remarkable performance in many data-driven and prediction-oriented applications, and sometimes even perform better than humans. However, their most significant drawback is the lack of interpretability,…

Machine Learning · Computer Science 2023-02-22 Jiahui Li , Kun Kuang , Lin Li , Long Chen , Songyang Zhang , Jian Shao , Jun Xiao

Development of several alternative mathematical models for the biological system in question and discrimination between such models using experimental data is the best way to robust conclusions. Models which challenge existing theories are…

Quantitative Methods · Quantitative Biology 2016-02-01 Vitaly V. Ganusov