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Large scale neural recordings have established that the transformation of sensory stimuli into motor outputs relies on low-dimensional dynamics at the population level, while individual neurons exhibit complex selectivity. Understanding how…

Neurons and Cognition · Quantitative Biology 2018-08-29 Francesca Mastrogiuseppe , Srdjan Ostojic

Recurrent neural networks (RNNs) trained on low-dimensional tasks have been widely used to model functional biological networks. However, the solutions found by learning and the effect of initial connectivity are not well understood. Here,…

Neurons and Cognition · Quantitative Biology 2021-05-17 Friedrich Schuessler , Francesca Mastrogiuseppe , Alexis Dubreuil , Srdjan Ostojic , Omri Barak

Low-rank recurrent neural networks (lrRNNs) are a class of models that uncover low-dimensional latent dynamics underlying neural population activity. Although their functional connectivity is low-rank, it lacks disentanglement…

Neurons and Cognition · Quantitative Biology 2025-11-19 Chengrui Li , Yunmiao Wang , Yule Wang , Weihan Li , Dieter Jaeger , Anqi Wu

Recurrent neural networks (RNNs) provide a theoretical framework for understanding computation in biological neural circuits, yet classical results, such as Hopfield's model of associative memory, rely on symmetric connectivity that…

Disordered Systems and Neural Networks · Physics 2026-02-17 Ramón Nartallo-Kaluarachchi , Renaud Lambiotte , Alain Goriely

Understanding the internal dynamics of Recurrent Neural Networks (RNNs) is crucial for advancing their interpretability and improving their design. This study introduces an innovative information-theoretic method to identify and analyze…

Machine Learning · Computer Science 2025-10-03 Arend Hintze , Asadullah Najam , Jory Schossau

Inferring synaptic connectivity from neural population activity is a fundamental challenge in computational neuroscience, complicated by partial observability and mismatches between inference models and true circuit dynamics. In this study,…

Neurons and Cognition · Quantitative Biology 2025-10-28 Kijung Yoon

Recurrent Neural Networks (RNNs) are popular models of brain function. The typical training strategy is to adjust their input-output behavior so that it matches that of the biological circuit of interest. Even though this strategy ensures…

Neurons and Cognition · Quantitative Biology 2020-11-09 Alessandro Salatiello , Martin A. Giese

Unified understanding of neuro networks (NNs) gets the users into great trouble because they have been puzzled by what kind of rules should be obeyed to optimize the internal structure of NNs. Considering the potential capability of random…

Machine Learning · Computer Science 2022-01-03 Ruiqi Mao , Rongxin Cui

Studies of the dynamics of nonlinear recurrent neural networks often assume independent and identically distributed couplings, but large-scale connectomics data indicate that biological neural circuits exhibit markedly different…

Neurons and Cognition · Quantitative Biology 2025-10-28 David G. Clark , Owen Marschall , Alexander van Meegen , Ashok Litwin-Kumar

Recurrent neural networks (RNNs) are widely used throughout neuroscience as models of local neural activity. Many properties of single RNNs are well characterized theoretically, but experimental neuroscience has moved in the direction of…

Machine Learning · Computer Science 2023-01-31 Leo Kozachkov , Michaela Ennis , Jean-Jacques Slotine

Task-based modeling with recurrent neural networks (RNNs) has emerged as a popular way to infer the computational function of different brain regions. These models are quantitatively assessed by comparing the low-dimensional neural…

Neurons and Cognition · Quantitative Biology 2019-12-06 Niru Maheswaranathan , Alex H. Williams , Matthew D. Golub , Surya Ganguli , David Sussillo

A recent strategy to circumvent the exploding and vanishing gradient problem in RNNs, and to allow the stable propagation of signals over long time scales, is to constrain recurrent connectivity matrices to be orthogonal or unitary. This…

Understanding how biological and artificial neural networks implement computation from connectivity is a central problem in neuroscience and machine learning. In neural systems, structural and functional connectivity are known to diverge,…

Neural and Evolutionary Computing · Computer Science 2026-05-07 Jatin Sharma , Dan F. M Goodman , Danyal Akarca

Recurrent neural networks (RNNs) provide a powerful approach in neuroscience to infer latent dynamics in neural populations and to generate hypotheses about the neural computations underlying behavior. However, past work has focused on…

Machine Learning · Computer Science 2025-10-30 Elia Torre , Michele Viscione , Lucas Pompe , Benjamin F Grewe , Valerio Mante

What can we learn from the collective dynamics of a complex network about its interaction topology? Taking the perspective from nonlinear dynamics, we briefly review recent progress on how to infer structural connectivity (direct…

Adaptation and Self-Organizing Systems · Physics 2014-08-14 Marc Timme , Jose Casadiego

A given neural network in the brain is involved in many different tasks. This implies that, when considering a specific task, the network's connectivity contains a component which is related to the task and another component which can be…

Neurons and Cognition · Quantitative Biology 2021-03-17 Friedrich Schuessler , Alexis Dubreuil , Francesca Mastrogiuseppe , Srdjan Ostojic , Omri Barak

Several approaches to cognition and intelligence research rely on statistics-based models testing, namely factor analysis. In the present work we exploit the emerging dynamical systems perspective putting the focus on the role of the…

Physics and Society · Physics 2018-03-15 Gemma Rosell-Tarragó , Emanuele Cozzo , Albert Díaz-Guilera

Recent advances in Neural Variational Inference allowed for a renaissance in latent variable models in a variety of domains involving high-dimensional data. While traditional variational methods derive an analytical approximation for the…

Machine Learning · Computer Science 2019-08-20 Alexander I. Cowen-Rivers , Pasquale Minervini , Tim Rocktaschel , Matko Bosnjak , Sebastian Riedel , Jun Wang

Understanding how network function constrains neural connectivity is a central challenge in neuroscience. An influential approach is to train neural networks with gradient descent on cognitive tasks and characterize the resulting…

Neurons and Cognition · Quantitative Biology 2026-05-26 Ludwig Hruza , Srdjan Ostojic

Recurrent neural networks have gained widespread use in modeling sequential data. Learning long-term dependencies using these models remains difficult though, due to exploding or vanishing gradients. In this paper, we draw connections…

Machine Learning · Statistics 2019-02-27 Bo Chang , Minmin Chen , Eldad Haber , Ed H. Chi
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