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Genetic mutations can cause disease by disrupting normal gene function. Identifying the disease-causing mutations from millions of genetic variants within an individual patient is a challenging problem. Computational methods which can…

Machine Learning · Computer Science 2021-06-28 Jun Cheng , Carolin Lawrence , Mathias Niepert

Knowledge graph reasoning (KGR), aiming to deduce new facts from existing facts based on mined logic rules underlying knowledge graphs (KGs), has become a fast-growing research direction. It has been proven to significantly benefit the…

Artificial Intelligence · Computer Science 2024-10-28 Ke Liang , Lingyuan Meng , Meng Liu , Yue Liu , Wenxuan Tu , Siwei Wang , Sihang Zhou , Xinwang Liu , Fuchun Sun

Large-scale genome-wide association studies (GWAS) have offered an exciting opportunity to discover putative causal genes or risk factors associated with diseases by using SNPs as instrumental variables (IVs). However, conventional…

Methodology · Statistics 2023-10-27 Ben Dai , Chunlin Li , Haoran Xue , Wei Pan , Xiaotong Shen

Knowledge graph (KG) embedding has been used to benefit the diagnosis of animal diseases by analyzing electronic medical records (EMRs), such as notes and veterinary records. However, learning representations to capture entities and…

Artificial Intelligence · Computer Science 2023-09-08 Van Thuy Hoang , Sang Thanh Nguyen , Sangmyeong Lee , Jooho Lee , Luong Vuong Nguyen , O-Joun Lee

Inferring missing links in knowledge graphs (KG) has attracted a lot of attention from the research community. In this paper, we tackle a practical query answering task involving predicting the relation of a given entity pair. We frame this…

Artificial Intelligence · Computer Science 2018-10-24 Wenhu Chen , Wenhan Xiong , Xifeng Yan , William Wang

Taking advantages of high-throughput genotyping technology of single nucleotide polymorphism (SNP), large genome-wide association studies (GWASs) have been considered as the promise to unravel the complex relationships between genotypes and…

Genomics · Quantitative Biology 2018-11-20 Xuan Guo

Knowledge graph embedding (KGE) focuses on representing the entities and relations of a knowledge graph (KG) into the continuous vector spaces, which can be employed to predict the missing triples to achieve knowledge graph completion…

Computation and Language · Computer Science 2023-07-25 Yichi Zhang , Wen Zhang

Knowledge graph question answering (KGQA) based on information retrieval aims to answer a question by retrieving answer from a large-scale knowledge graph. Most existing methods first roughly retrieve the knowledge subgraphs (KSG) that may…

Computation and Language · Computer Science 2022-10-06 Hanning Gao , Lingfei Wu , Po Hu , Zhihua Wei , Fangli Xu , Bo Long

Knowledge Graphs (KGs) represent human-crafted factual knowledge in the form of triplets (head, relation, tail), which collectively form a graph. Question Answering over KGs (KGQA) is the task of answering natural questions grounding the…

Computation and Language · Computer Science 2024-05-31 Costas Mavromatis , George Karypis

Knowledge-graph retrieval-augmented generation (KG-RAG) couples large language models (LLMs) with structured, verifiable knowledge graphs (KGs) to reduce hallucination and provide reasoning traces. However, current KG-RAG systems often rely…

Computation and Language · Computer Science 2026-05-25 Junhong Lin , Shicheng Liu , Jinyeop Song , Song Wang , Julian Shun , Yada Zhu

Large Language Models (LLMs) and Knowledge Graphs (KGs) offer a promising approach to robust and explainable Question Answering (QA). While LLMs excel at natural language understanding, they suffer from knowledge gaps and hallucinations.…

Machine Learning · Computer Science 2025-04-15 Jasper Linders , Jakub M. Tomczak

Reasoning over knowledge graphs (KGs) is a challenging task that requires a deep understanding of the complex relationships between entities and the underlying logic of their relations. Current approaches rely on learning geometries to…

Logic in Computer Science · Computer Science 2024-04-02 Nurendra Choudhary , Chandan K. Reddy

Genome-Wide Association Studies (GWAS) face unique challenges in the era of big genomics data, particularly when dealing with ultra-high-dimensional datasets where the number of genetic features significantly exceeds the available samples.…

Genomics · Quantitative Biology 2023-12-27 Kexuan Li

Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the…

Genomics · Quantitative Biology 2015-04-09 Andrew L. Beam , Alison Motsinger-Reif , Jon Doyle

Retrieval-augmented generation (RAG) has emerged as a promising technology for addressing hallucination issues in the responses generated by large language models (LLMs). Existing studies on RAG primarily focus on applying semantic-based…

Computation and Language · Computer Science 2025-02-12 Xiangrong Zhu , Yuexiang Xie , Yi Liu , Yaliang Li , Wei Hu

Despite the recent successes of deep neural networks, it remains challenging to achieve high precision keyword spotting task (KWS) on resource-constrained devices. In this study, we propose a novel context-aware and compact architecture for…

Sound · Computer Science 2019-12-12 Xi Chen , Shouyi Yin , Dandan Song , Peng Ouyang , Leibo Liu , Shaojun Wei

Generative commonsense reasoning which aims to empower machines to generate sentences with the capacity of reasoning over a set of concepts is a critical bottleneck for text generation. Even the state-of-the-art pre-trained language…

Computation and Language · Computer Science 2021-01-22 Ye Liu , Yao Wan , Lifang He , Hao Peng , Philip S. Yu

Inductive knowledge graph completion (KGC) aims to predict missing triples with unseen entities. Recent works focus on modeling reasoning paths between the head and tail entity as direct supporting evidence. However, these methods depend…

Artificial Intelligence · Computer Science 2024-12-30 Muzhi Li , Cehao Yang , Chengjin Xu , Zixing Song , Xuhui Jiang , Jian Guo , Ho-fung Leung , Irwin King

Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness between core biomedical concepts, enable…

Genomic data arising from a genome-wide association study (GWAS) are often not only of large-scale, but also incomplete. A specific form of their incompleteness is missing values with non-ignorable missingness mechanism. The intrinsic…

Methodology · Statistics 2021-11-11 Siru Wang , Guoqi Qian