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Predicting compound-protein affinity is critical for accelerating drug discovery. Recent progress made by machine learning focuses on accuracy but leaves much to be desired for interpretability. Through molecular contacts underlying…

Biomolecules · Quantitative Biology 2020-01-01 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

Deep neural networks have demonstrated superior performance in artificial intelligence applications, but the opaqueness of their inner working mechanism is one major drawback in their application. The prevailing unit-based interpretation is…

Computer Vision and Pattern Recognition · Computer Science 2024-02-29 Lei Lyu , Chen Pang , Jihua Wang

Deep learning has transformed computer vision (CV), achieving outstanding performance in classification, segmentation, and related tasks. Such AI-based CV systems are becoming prevalent, with applications spanning from medical imaging to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Neo Christopher Chung , Jakub Binda

Cybersecurity is a domain where the data distribution is constantly changing with attackers exploring newer patterns to attack cyber infrastructure. Intrusion detection system is one of the important layers in cyber safety in today's world.…

Cryptography and Security · Computer Science 2021-03-15 Shraddha Mane , Dattaraj Rao

Click-Through Rate prediction (CTR) is a crucial task in recommender systems, and it gained considerable attention in the past few years. The primary purpose of recent research emphasizes obtaining meaningful and powerful representations…

Information Retrieval · Computer Science 2022-10-26 Shereen Elsayed , Lars Schmidt-Thieme

Deep learning models often function as black boxes, providing no straightforward reasoning for their predictions. This is particularly true for computer vision models, which process tensors of pixel values to generate outcomes in tasks such…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Sachin Karmani , Thanushon Sivakaran , Gaurav Prasad , Mehmet Ali , Wenbo Yang , Sheyang Tang

With the availability of large databases and recent improvements in deep learning methodology, the performance of AI systems is reaching or even exceeding the human level on an increasing number of complex tasks. Impressive examples of this…

Artificial Intelligence · Computer Science 2017-08-29 Wojciech Samek , Thomas Wiegand , Klaus-Robert Müller

Deep Reinforcement Learning (DRL) has achieved remarkable success in sequential decision-making tasks across diverse domains, yet its reliance on black-box neural architectures hinders interpretability, trust, and deployment in high-stakes…

Machine Learning · Computer Science 2025-02-12 Zelei Cheng , Jiahao Yu , Xinyu Xing

We present a methodology for model evaluation and selection where the sampling mechanism violates the i.i.d. assumption. Our methodology involves a formulation of the bias between the standard Cross-Validation (CV) estimator and the mean…

Methodology · Statistics 2025-03-14 Oren Yuval , Saharon Rosset

Virtual screening can accelerate drug discovery by identifying promising candidates for experimental evaluation. Machine learning is a powerful method for screening, as it can learn complex structure-property relationships from experimental…

Machine Learning · Computer Science 2021-02-22 Simon Axelrod , Rafael Gomez-Bombarelli

Introduction: Machine learning provides fundamental tools both for scientific research and for the development of technologies with significant impact on society. It provides methods that facilitate the discovery of regularities in data and…

Machine Learning · Computer Science 2019-03-12 Andrea Ceni , Peter Ashwin , Lorenzo Livi

The advancements in deep learning-based methods for visual perception tasks have seen astounding growth in the last decade, with widespread adoption in a plethora of application areas from autonomous driving to clinical decision support…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Kumar Abhishek , Deeksha Kamath

Artificial Intelligence (AI) has made leapfrogs in development across all the industrial sectors especially when deep learning has been introduced. Deep learning helps to learn the behaviour of an entity through methods of recognising and…

Machine Learning · Computer Science 2021-04-30 Qinghao Ye , Jun Xia , Guang Yang

Recent developments in generative artificial intelligence (AI) rely on machine learning techniques such as deep learning and generative modeling to achieve state-of-the-art performance across wide-ranging domains. These methods' surprising…

Machine Learning · Statistics 2026-01-27 Gemma E. Moran , Bryon Aragam

Prediction and control of chemical mixing are vital for many scientific areas such as subsurface reactive transport, climate modeling, combustion, epidemiology, and pharmacology. Due to the complex nature of mixing in heterogeneous and…

Machine Learning · Computer Science 2021-12-15 N. V. Jagtap , M. K. Mudunuru , K. B. Nakshatrala

EXplainable AI (XAI) methods have been proposed to interpret how a deep neural network predicts inputs through model saliency explanations that highlight the parts of the inputs deemed important to arrive a decision at a specific target.…

Computer Vision and Pattern Recognition · Computer Science 2020-09-23 Yi-Shan Lin , Wen-Chuan Lee , Z. Berkay Celik

The Deep learning (DL) models for diagnosing breast cancer from mammographic images often operate as "black boxes", making it difficult for healthcare professionals to trust and understand their decision-making processes. The study presents…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Maryam Ahmed , Tooba Bibi , Rizwan Ahmed Khan , Sidra Nasir

Deep learning has been shown to be highly effective for automatic modulation classification (AMC), which is a pivotal technology for next-generation cognitive communications. Yet, existing deep learning methods for AMC often lack robust…

Signal Processing · Electrical Eng. & Systems 2025-12-03 Huian Yang , Rajeev Sahay

Hardware imperfections in RF transmitters introduce features that can be used to identify a specific transmitter amongst others. Supervised deep learning has shown good performance in this task but using datasets not applicable to real…

Signal Processing · Electrical Eng. & Systems 2019-05-21 Cyrille Morin , Leonardo Cardoso , Jakob Hoydis , Jean-Marie Gorce , Thibaud Vial

Deep neural networks (DNNs) have achieved substantial predictive performance in various speech processing tasks. Particularly, it has been shown that a monaural speech separation task can be successfully solved with a DNN-based method…

Audio and Speech Processing · Electrical Eng. & Systems 2021-04-20 Chihiro Watanabe , Hirokazu Kameoka