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Learning electronic health records (EHRs) has received emerging attention because of its capability to facilitate accurate medical diagnosis. Since the EHRs contain enriched information specifying complex interactions between entities,…

Machine Learning · Computer Science 2024-08-15 Tsai Hor Chan , Guosheng Yin , Kyongtae Bae , Lequan Yu

We propose RareGraph-Synth, a knowledge-guided, continuous-time diffusion framework that generates realistic yet privacy-preserving synthetic electronic-health-record (EHR) trajectories for ultra-rare diseases. RareGraph-Synth unifies five…

Machine Learning · Computer Science 2025-10-09 Khartik Uppalapati , Shakeel Abdulkareem , Bora Yimenicioglu

The integration of multimodal Electronic Health Records (EHR) data has significantly advanced clinical predictive capabilities. Existing models, which utilize clinical notes and multivariate time-series EHR data, often fall short of…

Computation and Language · Computer Science 2025-02-27 Yinghao Zhu , Changyu Ren , Zixiang Wang , Xiaochen Zheng , Shiyun Xie , Junlan Feng , Xi Zhu , Zhoujun Li , Liantao Ma , Chengwei Pan

The introduction of electronic personal health records (EHR) enables nationwide information exchange and curation among different health care systems. However, the current EHR systems do not provide transparent means for diagnosis support,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-10-04 Dragi Kimovski , Sasko Ristov , Radu Prodan

Electronic Health Records (EHRs) contain extensive patient information that can inform downstream clinical decisions, such as mortality prediction, disease phenotyping, and disease onset prediction. A key challenge in EHR data analysis is…

Applications · Statistics 2026-01-01 Xin Gai , Shiyi Jiang , Anru R. Zhang

Longitudinal multimodal data, including electronic health records (EHR) and sequential chest X-rays (CXRs), is critical for modeling disease progression, yet remains underutilized due to two key challenges: (1) redundancy in consecutive CXR…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Chen Liu , Wenfang Yao , Kejing Yin , William K. Cheung , Jing Qin

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

In electronic health records (EHRs), clustering patients and distinguishing disease subtypes are key tasks to elucidate pathophysiology and aid clinical decision-making. However, clustering in healthcare informatics is still based on…

Machine Learning · Computer Science 2026-04-09 Manar D. Samad , Yina Hou , Shrabani Ghosh

Integrating multimodal Electronic Health Records (EHR) data, such as numerical time series and free-text clinical reports, has great potential in predicting clinical outcomes. However, prior work has primarily focused on capturing temporal…

Machine Learning · Computer Science 2025-11-10 Fuying Wang , Feng Wu , Yihan Tang , Lequan Yu

Chest X-ray (CXR) is an important diagnostic tool widely used in hospitals to assess patient conditions and monitor changes over time. Recently, generative models, specifically diffusion-based models, have shown promise in generating…

Image and Video Processing · Electrical Eng. & Systems 2025-05-07 Daeun Kyung , Junu Kim , Tackeun Kim , Edward Choi

Deep learning in cardiac MRI (CMR) is fundamentally constrained by both data scarcity and privacy regulations. This study systematically benchmarks three generative architectures: Denoising Diffusion Probabilistic Models (DDPM), Latent…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Madhura Edirisooriya , Dasuni Kawya , Ishan Kumarasinghe , Isuri Devindi , Mary M. Maleckar , Roshan Ragel , Isuru Nawinne , Vajira Thambawita

Healthcare is becoming a more and more important research topic recently. With the growing data in the healthcare domain, it offers a great opportunity for deep learning to improve the quality of medical service. However, the complexity of…

Computation and Language · Computer Science 2021-11-01 Bo Yang , Lijun Wu

The present study introduces an innovative approach to the synthesis of Electroencephalogram (EEG) signals by integrating diffusion models with reinforcement learning. This integration addresses key challenges associated with traditional…

Signal Processing · Electrical Eng. & Systems 2024-10-02 Yang An , Yuhao Tong , Weikai Wang , Steven W. Su

Clinical time series derived from electronic health records (EHRs) are inherently irregular, with asynchronous sampling, missing values, and heterogeneous feature dynamics. While numerical laboratory measurements are highly informative,…

Artificial Intelligence · Computer Science 2025-11-13 Yi-Hsien Hsieh , Ta-Jung Chien , Chun-Kai Huang , Shao-Hua Sun , Che Lin

Data scarcity in the brain-computer interface field can be alleviated through the use of generative models, specifically diffusion models. While diffusion models have previously been successfully applied to electroencephalogram (EEG) data,…

Machine Learning · Computer Science 2024-11-05 Guido Klein , Pierre Guetschel , Gianluigi Silvestri , Michael Tangermann

The wide adoption of Electronic Health Records (EHR) has resulted in large amounts of clinical data becoming available, which promises to support service delivery and advance clinical and informatics research. Deep learning techniques have…

Machine Learning · Computer Science 2022-02-14 Thanh Nguyen-Duc , Natasha Mulligan , Gurdeep S. Mannu , Joao H. Bettencourt-Silva

The limited data availability due to strict privacy regulations and significant resource demands severely constrains biomedical time-series AI development, which creates a critical gap between data requirements and accessibility. Synthetic…

Machine Learning · Computer Science 2025-11-25 Youngjoon Lee , Seongmin Cho , Yehhyun Jo , Jinu Gong , Hyunjoo Jenny Lee , Joonhyuk Kang

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

This study proposes a risk prediction method based on a Multi-Scale Temporal Alignment Network (MSTAN) to address the challenges of temporal irregularity, sampling interval differences, and multi-scale dynamic dependencies in Electronic…

Machine Learning · Computer Science 2025-11-27 Wei-Chen Chang , Lu Dai , Ting Xu

Research is a tertiary priority in the EHR, where the priorities are patient care and billing. Because of this, the data is not standardized or formatted in a manner easily adapted to machine learning approaches. Data may be missing for a…

Machine Learning · Computer Science 2017-07-25 Brett K. Beaulieu-Jones