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Quantum Computing offers a potentially powerful new method for performing Machine Learning. However, several Quantum Machine Learning techniques have been shown to exhibit poor generalisation as the number of qubits increases. We address…

Quantum Physics · Physics 2024-05-21 Jamie Heredge , Charles Hill , Lloyd Hollenberg , Martin Sevior

Molecular conformer generation is a fundamental task in computational chemistry. Several machine learning approaches have been developed, but none have outperformed state-of-the-art cheminformatics methods. We propose torsional diffusion, a…

Chemical Physics · Physics 2023-03-02 Bowen Jing , Gabriele Corso , Jeffrey Chang , Regina Barzilay , Tommi Jaakkola

We present a probabilistic model for point cloud generation, which is fundamental for various 3D vision tasks such as shape completion, upsampling, synthesis and data augmentation. Inspired by the diffusion process in non-equilibrium…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Shitong Luo , Wei Hu

Riemannian diffusion models draw inspiration from standard Euclidean space diffusion models to learn distributions on general manifolds. Unfortunately, the additional geometric complexity renders the diffusion transition term inexpressible…

Machine Learning · Computer Science 2023-11-01 Aaron Lou , Minkai Xu , Stefano Ermon

Continuous diffusion models have demonstrated remarkable performance in data generation across various domains, yet their efficiency remains constrained by two critical limitations: (1) the local adjacency structure of the forward Markov…

Machine Learning · Statistics 2025-05-29 Xunpeng Huang , Yingyu Lin , Nikki Lijing Kuang , Hanze Dong , Difan Zou , Yian Ma , Tong Zhang

Classical diffusion models have shown superior generative results. Exploring them in the quantum domain can advance the field of quantum generative learning. This work introduces Quantum Generative Diffusion Model (QGDM) as their simple and…

Quantum Physics · Physics 2024-08-06 Chuangtao Chen , Qinglin Zhao , MengChu Zhou , Zhimin He , Zhili Sun , Haozhen Situ

Recent deep learning approaches seek to automate CAD creation by representing a model as a sequence of discrete commands and parameters, and then generating them using autoregressive models or continuous diffusion operating in Euclidean…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Honghu Pan , Xiaoling Luo , Yongyong Chen , Zhenyu He , Pengyang Wang

Quantum computing has recently emerged as a transformative technology. Yet, its promised advantages rely on efficiently translating quantum operations into viable physical realizations. In this work, we use generative machine learning…

Quantum Physics · Physics 2024-05-22 Florian Fürrutter , Gorka Muñoz-Gil , Hans J. Briegel

Molecule generation, especially generating 3D molecular geometries from scratch (i.e., 3D \textit{de novo} generation), has become a fundamental task in drug designs. Existing diffusion-based 3D molecule generation methods could suffer from…

Machine Learning · Computer Science 2022-09-14 Lei Huang , Hengtong Zhang , Tingyang Xu , Ka-Chun Wong

Generating realistic 3D point clouds is a fundamental problem in computer vision with applications in remote sensing, robotics, and digital object modeling. Existing generative approaches primarily capture geometry, and when semantics are…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Gunner Stone , Sushmita Sarker , Alireza Tavakkoli

Recent advances in diffusion models have shown remarkable potential in the conditional generation of novel molecules. These models can be guided in two ways: (i) explicitly, through additional features representing the condition, or (ii)…

Machine Learning · Computer Science 2025-03-12 Yuchen Shen , Chenhao Zhang , Sijie Fu , Chenghui Zhou , Newell Washburn , Barnabás Póczos

Simulation is crucial for all aspects of collider data analysis, but the available computing budget in the High Luminosity LHC era will be severely constrained. Generative machine learning models may act as surrogates to replace…

Instrumentation and Detectors · Physics 2023-10-04 Oz Amram , Kevin Pedro

Quantum computing is a transformative technology with wide-ranging applications, and efficient quantum circuit generation is crucial for unlocking its full potential. Current diffusion model approaches based on U-Net architectures, while…

Machine Learning · Computer Science 2025-01-29 Zhiwei Chen , Hao Tang

Diffusion-based models have shown great promise in molecular generation but often require a large number of sampling steps to generate valid samples. In this paper, we introduce a novel Straight-Line Diffusion Model (SLDM) to tackle this…

Machine Learning · Computer Science 2025-06-10 Yuyan Ni , Shikun Feng , Haohan Chi , Bowen Zheng , Huan-ang Gao , Wei-Ying Ma , Zhi-Ming Ma , Yanyan Lan

Generative modelling aims to accelerate the discovery of novel chemicals by directly proposing structures with desirable properties. Recently, score-based, or diffusion, generative models have significantly outperformed previous approaches.…

Diffusion-based generative models represent the current state-of-the-art for image generation. However, standard diffusion models are based on Euclidean geometry and do not translate directly to manifold-valued data. In this work, we…

Machine Learning · Computer Science 2023-12-20 Yesukhei Jagvaral , Francois Lanusse , Rachel Mandelbaum

Diffusion models have emerged as powerful generative models, but their high computation cost in iterative sampling remains a significant bottleneck. In this work, we present an in-depth and insightful study of state-of-the-art acceleration…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Weizhi Gao , Zhichao Hou , Junqi Yin , Feiyi Wang , Linyu Peng , Xiaorui Liu

We propose kernel-gradient drifting, a one-step generative modeling framework that replaces the fixed Euclidean displacement direction in drifting models with directions induced by the kernel itself. Standard drifting is attractive because…

Recent developments in the field of quantum machine learning have promoted the idea of incorporating physical symmetries in the structure of quantum circuits. A crucial milestone in this area is the realization of $S_{n}$-permutation…

Quantum Physics · Physics 2024-08-20 Zhelun Li , Lento Nagano , Koji Terashi

Generative modeling within constrained sets is essential for scientific and engineering applications involving physical, geometric, or safety requirements (e.g., molecular generation, robotics). We present a unified framework for…

Machine Learning · Computer Science 2026-04-21 Kijung Jeon , Michael Muehlebach , Molei Tao