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Until recently, transcriptomics was limited to bulk RNA sequencing, obscuring the underlying expression patterns of individual cells in favor of a global average. Thanks to technological advances, we can now profile gene expression across…

Quantitative Methods · Quantitative Biology 2018-11-30 Miriam Shiffman , William T. Stephenson , Geoffrey Schiebinger , Jonathan Huggins , Trevor Campbell , Aviv Regev , Tamara Broderick

Bayesian filtering and smoothing for high-dimensional nonlinear dynamical systems are fundamental yet challenging problems in many areas of science and engineering. In this work, we propose FLUID, a flow-based unified amortized inference…

Machine Learning · Statistics 2026-04-27 Tiangang Cui , Xiaodong Feng , Chenlong Pei , Xiaoliang Wan , Tao Zhou

Generative models like Flow Matching have achieved state-of-the-art performance but are often hindered by a computationally expensive iterative sampling process. To address this, recent work has focused on few-step or one-step generation by…

Machine Learning · Computer Science 2025-07-24 Yi Guo , Wei Wang , Zhihang Yuan , Rong Cao , Kuan Chen , Zhengyang Chen , Yuanyuan Huo , Yang Zhang , Yuping Wang , Shouda Liu , Yuxuan Wang

We present DistillFlow, a knowledge distillation approach to learning optical flow. DistillFlow trains multiple teacher models and a student model, where challenging transformations are applied to the input of the student model to generate…

Computer Vision and Pattern Recognition · Computer Science 2021-06-09 Pengpeng Liu , Michael R. Lyu , Irwin King , Jia Xu

Paediatric Acute Myeloid Leukemia is a complex adaptive ecosystem with high morbidity. Current trajectory inference algorithms struggle to predict causal dynamics in AML progression, including relapse and recurrence risk. We propose a…

Quantitative Methods · Quantitative Biology 2025-08-20 Abicumaran Uthamacumaran , Hector Zenil

Spatiotemporal flows of neural activity, such as traveling waves, have been observed throughout the brain since the earliest recordings; yet there is still little consensus on their functional role. Recent experiments and models have linked…

Neurons and Cognition · Quantitative Biology 2026-02-03 T. Anderson Keller , Lyle Muller , Terrence J. Sejnowski , Max Welling

Flow Matching has limited ability in achieving one-step generation due to its reliance on learned curved trajectories. Previous studies have attempted to address this limitation by either modifying the coupling distribution to prevent…

Machine Learning · Computer Science 2025-11-25 Chenrui Ma , Xi Xiao , Tianyang Wang , Xiao Wang , Yanning Shen

In this paper, we present a physics-based deep learning framework for data-driven prediction of wave propagation in fluid media. The proposed approach, termed Multistep Integration-Inspired Attention (MI2A), combines a denoising-based…

Machine Learning · Computer Science 2025-04-16 Indu Kant Deo , Rajeev K. Jaiman

Accelerating materials development requires quantitative linkages between processing, microstructure, and properties. In this work, we introduce a framework for mapping microstructure onto a low-dimensional material manifold that is…

Materials Science · Physics 2026-05-20 Simon A. Mason , Megna N. Shah , Jeffrey P. Simmons , Dennis M. Dimiduk , Stephen R. Niezgoda

We investigate stochastic interpolation, a recently introduced framework for high dimensional sampling which bears many similarities to diffusion modeling. Stochastic interpolation generates a data sample by first randomly initializing a…

Statistics Theory · Mathematics 2025-10-28 Mara Daniels

Protein sequence generation for engineering requires samples that are biophysically plausible and, when targeting a family/domain, remain recognizable members while exploring within-family diversity. Current discrete generative models…

Computational Engineering, Finance, and Science · Computer Science 2026-05-25 Langzhang Liang , Ming Yang , Yi Feng , Junfan Li , Shirui Pan , Yinghui Xu , Tianlei Ying , Yizhen Zheng , Zenglin Xu

Autonomous driving requires reasoning about interactions with surrounding traffic. A prevailing approach is large-scale imitation learning on expert driving datasets, aimed at generalizing across diverse real-world scenarios. For online…

Structural changes in a network representation of a system (e.g.,different experimental conditions, time evolution), can provide insight on its organization, function and on how it responds to external perturbations. The deeper…

Data Analysis, Statistics and Probability · Physics 2021-01-04 Leonardo L. Portes , Michael Small

Various modifications of decision trees have been extensively used during the past years due to their high efficiency and interpretability. Tree node splitting based on relevant feature selection is a key step of decision tree learning, at…

Machine Learning · Computer Science 2017-09-05 Dmitry Ignatov , Andrey Ignatov

Dynamical models underpin our ability to understand and predict the behavior of natural systems. Whether dynamical models are developed from first-principles derivations or from observational data, they are predicated on our choice of state…

Machine Learning · Computer Science 2023-01-11 Daniel Floryan , Michael D. Graham

Estimating the correspondences between pixels in sequences of images is a critical first step for a myriad of tasks including vision-aided navigation (e.g., visual odometry (VO), visual-inertial odometry (VIO), and visual simultaneous…

Image and Video Processing · Electrical Eng. & Systems 2018-03-16 E. Jared Shamwell , William D. Nothwang , Donald Perlis

Driving planning is a critical component of end-to-end (E2E) autonomous driving. However, prevailing Imitative E2E Planners often suffer from multimodal trajectory mode collapse, failing to produce diverse trajectory proposals. Meanwhile,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Lin Liu , Caiyan Jia , Guanyi Yu , Ziying Song , JunQiao Li , Feiyang Jia , Peiliang Wu , Xiaoshuai Hao , Yadan Luo

In the field of machine learning, comprehending the intricate training dynamics of neural networks poses a significant challenge. This paper explores the training dynamics of neural networks, particularly whether these dynamics can be…

Machine Learning · Computer Science 2024-08-16 Yeachan Park

Understanding and predicting microstructure evolution is fundamental to materials science, as it governs the resulting properties and performance of materials. Traditional simulation methods, such as phase-field models, offer high-fidelity…

Machine Learning · Computer Science 2026-02-24 Michael Trimboli , Mohammed Alsubaie , Sirani M. Perera , Ke-Gang Wang , Xianqi Li

Understanding the dynamic nature of biological systems is fundamental to deciphering cellular behavior, developmental processes, and disease progression. Single-cell RNA sequencing (scRNA-seq) has provided static snapshots of gene…

Quantitative Methods · Quantitative Biology 2025-05-02 Zhenyi Zhang , Yuhao Sun , Qiangwei Peng , Tiejun Li , Peijie Zhou
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