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We present a single, unified, multi-scale model to study the attachment\detachment dynamics of two deforming, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous fluid medium. The…

Cell Behavior · Quantitative Biology 2015-04-23 Sarthok Sircar , Anthony J. Roberts

Discrete Element Methods (DEM) are a useful tool to model the fracture of cohesive granular materials. For this kind of application, simple particle shapes (discs in 2D, spheres in 3D) are usually employed. However, dealing with more…

Soft Condensed Matter · Physics 2016-07-07 A Neveu , R Artoni , P Richard , Y Descantes

The self-organization of proteins into enriched compartments and the formation of complex patterns are crucial processes for life on the cellular level. Liquid-liquid phase separation is one mechanism for forming such enriched compartments.…

Soft Condensed Matter · Physics 2025-04-07 Antonia Winter , Yuhao Liu , Alexander Ziepke , George Dadunashvili , Erwin Frey

In this study, we explore mixed-dimensional Thermo-Hydro-Mechanical (THM) models in fractured porous media accounting for Coulomb frictional contact at matrix fracture interfaces. The simulation of such models plays an important role in…

Numerical Analysis · Mathematics 2024-01-24 Jerome Droniou , Mohamed Laaziri , Roland Masson

We cope with a free boundary fluid-structure interaction model. In the model, the viscous incompressible fluid interacts with elastic body via the common boundary. The motion of the fluid is governed by Navier-Stokes equations while the…

Analysis of PDEs · Mathematics 2019-02-19 Yizhao Qin , Pengfei Yao

The non-linear interaction between air and a water droplet just prior to high-speed impingement on a surface is a phenomenon that has been researched extensively and occurs in a number of industrial settings. The role that surface…

Fluid Dynamics · Physics 2021-10-07 Nathaniel I. J. Henman , Frank T. Smith , Manish K. Tiwari

There is an ever-growing need for predictive models for the elasto-viscoplastic deformation of solids. Our goal in this paper is to incorporate recently developed out-of-equilibrium statistical concepts into a thermodynamically consistent,…

Materials Science · Physics 2015-06-18 Ken Kamrin , Eran Bouchbinder

Recent advances in physics-augmented neural networks have enabled thermodynamically consistent data-driven constitutive modeling of complex inelastic materials. Most existing approaches, however, implicitly adopt a specific thermodynamic…

Materials Science · Physics 2026-05-28 Reese E. Jones , Jan N. Fuhg

The fluid dynamics community has found success in explaining both the onset and coherent structure formation in wall-bounded turbulence through examining transient growth and pseudoresonance. Whether similar effects are important in plasmas…

Plasma Physics · Physics 2024-11-01 Elias Pratschke

A microfluidic device is constructed from PDMS with a single channel having a short section that is a thin flexible membrane, in order to investigate the complex fluid-structure interaction that arises between a flowing fluid and a…

Soft Condensed Matter · Physics 2020-07-03 Debadi Chakraborty , J. Ravi Prakash , Leslie Yeo , James Friend

We consider a nonlinear, free boundary fluid-structure interaction model in a bounded domain. The viscous incompressible fluid interacts with a nonlinear elastic body on the common boundary via the velocity and stress matching conditions.…

Analysis of PDEs · Mathematics 2018-02-05 Yizhao Qin , Pengfei Yao

The modeling of coupled fluid transport and deformation in a porous medium is essential to predict the various geomechanical process such as CO2 sequestration, hydraulic fracturing, and so on. Current applications of interest, for instance,…

Analysis of PDEs · Mathematics 2022-01-03 Mina Karimi , Mehrdad Massoudi , Noel Walkington , Matteo Pozzi , Kaushik Dayal

Drops on a vibrating substrate can experience a variety of motion regimes, including directional motion and climbing. The key ingredient to elicit these regimes is simultaneously activating the in-plane and out-of-plane degrees of freedom…

Fluid Dynamics · Physics 2025-03-27 Sergio Santos , Zakari Kujala , Sungyon Lee , Stefano Gonella

We derive a continuum model for incompatible elasticity as a variational limit of a family of discrete nearest-neighbor elastic models. The discrete models are based on discretizations of a smooth Riemannian manifold $(M,\mathfrak{g})$,…

Analysis of PDEs · Mathematics 2019-01-23 Raz Kupferman , Cy Maor

We present a compelling finite element framework to model hydrogen assisted fatigue by means of a hydrogen- and cycle-dependent cohesive zone formulation. The model builds upon: (i) appropriate environmental boundary conditions, (ii) a…

Materials Science · Physics 2017-11-29 Susana del Busto , Covadonga Betegón , Emilio Martínez-Pañeda

We study large deformations of hyperelastic membranes using a purely two-dimensional formulation derived from basic balance principles within a modern geometric setting, ensuring a framework that is independent of an underlying…

Soft Condensed Matter · Physics 2025-09-22 Claudia Grabs , Werner Wirges

The mechanical properties of metal matrix fiber-reinforced composites depend on many aspects of their structure in a complicated way. In this paper, we propose a \emph{minimalistic} approach to study interface debonding, matrix cracking,…

Materials Science · Physics 2021-10-26 Zhaoyang Hu , Xufei Suo , Feng Jiang , Yongxing Shen

We consider a model of a biomembrane with attached proteins. The membrane is represented by a near spherical continuous surface and attached proteins are described as discrete rigid structures which attach to the membrane at a finite number…

Analysis of PDEs · Mathematics 2021-12-14 Charles M. Elliott , Philip J. Herbert

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

Soft Condensed Matter · Physics 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

Biomembranes play a central role in various phenomena like locomotion of cells, cell-cell interactions, packaging of nutrients, and in maintaining organelle morphology and functionality. During these processes, the membranes undergo…

Quantitative Methods · Quantitative Biology 2021-12-01 Debabrata Auddya , Xiaoxuan Zhang , Rahul Gulati , Ritvik Vasan , Krishna Garikipati , Padmini Rangamani , Shiva Rudraraju
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