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Reaching a global view of brain organization requires assembling evidence on widely different mental processes and mechanisms. The variety of human neuroscience concepts and terminology poses a fundamental challenge to relating brain…

Quantitative Methods · Quantitative Biology 2020-02-24 Jérôme Dockès , Russell Poldrack , Romain Primet , Hande Gözükan , Tal Yarkoni , Fabian Suchanek , Bertrand Thirion , Gaël Varoquaux

Recent neuroimaging studies that focus on predicting brain disorders via modern machine learning approaches commonly include a single modality and rely on supervised over-parameterized models.However, a single modality provides only a…

The connectome, a map of the structural and/or functional connections in the brain, provides a complex representation of the neurobiological phenotypes on which it supervenes. This information-rich data modality has the potential to…

Motivated by modern observational studies, we introduce a class of functional models that expands nested and crossed designs. These models account for the natural inheritance of correlation structure from sampling design in studies where…

Applications · Statistics 2013-04-26 Haochang Shou , Vadim Zipunnikov , Ciprian M. Crainiceanu , Sonja Greven

Bayesian neural networks (BNNs) augment deep networks with uncertainty quantification by Bayesian treatment of the network weights. However, such models face the challenge of Bayesian inference in a high-dimensional and usually…

Machine Learning · Computer Science 2021-03-30 Zhijie Deng , Yucen Luo , Jun Zhu , Bo Zhang

Foundation models are transforming neuroscience but are often prohibitively large, data-hungry, and difficult to deploy. Here, we introduce BrainSymphony, a lightweight and parameter-efficient foundation model with plug-and-play integration…

Quantitative Methods · Quantitative Biology 2026-02-13 Moein Khajehnejad , Forough Habibollahi , Devon Stoliker , Adeel Razi

Experiments that study neural encoding of stimuli at the level of individual neurons typically choose a small set of features present in the world --- contrast and luminance for vision, pitch and intensity for sound --- and assemble a…

Machine Learning · Statistics 2016-11-22 Xin , Chen , Jeffrey M Beck , John M Pearson

While it is well known that high levels of prenatal alcohol exposure (PAE) result in significant cognitive deficits in children, the exact nature of the dose response is less well understood. In particular, there is a pressing need to…

Detecting shared neural activity from functional magnetic resonance imaging (fMRI) across individuals exposed to the same stimulus can reveal synchronous brain responses, functional roles of regions, and potential clinical biomarkers.…

Applications · Statistics 2026-04-24 Spencer Wadsworth , Nabin Koirala , Nicole Landi , Ofer Harel

In recent years, neuroimaging has undergone a paradigm shift, moving away from the traditional brain mapping approach toward developing integrated, multivariate brain models that can predict categories of mental events. However, large…

Applications · Statistics 2022-09-19 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

The brain is a complex organ characterized by heterogeneous patterns of structural connections supporting unparalleled feats of cognition and a wide range of behaviors. New noninvasive imaging techniques now allow these patterns to be…

Neurons and Cognition · Quantitative Biology 2020-04-03 Christopher W. Lynn , Danielle S. Bassett

Various brain functions that are necessary to maintain life activities materialize through the interaction of countless neurons. Therefore, it is important to analyze functional neuronal network. To elucidate the mechanism of brain…

Neurons and Cognition · Quantitative Biology 2023-06-29 Shun Kimura , Koujin Takeda

In this paper we will focus on the potential and on the challenges associated with the development of an integrated brain and spinal cord modelling framework for processing MR neuroimaging data. The aim of the work is to explore how a…

Computer Vision and Pattern Recognition · Computer Science 2017-07-06 Claudia Blaiotta , Patrick Freund , M. Jorge Cardoso , John Ashburner

Real-world networks often benefit from capturing both local and global interactions. Inspired by multi-modal analysis in brain imaging, where structural and functional connectivity offer complementary views of network organization, we…

Neural and Evolutionary Computing · Computer Science 2025-08-11 Yang Li , Luopeiwen Yi , Tananun Songdechakraiwut

Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major breakthroughs…

Applications · Statistics 2026-02-16 Jian Kang , Thomas Nichols , Lexin Li , Martin A. Lindquist , Hongtu Zhu

The anatomical structure of the brain can be observed via non-invasive techniques such as diffusion imaging. However, these are imperfect because they miss connections that are actually known to exist, especially long range…

Neurons and Cognition · Quantitative Biology 2015-02-25 Somwrita Sarkar , Sanjay Chawla , Donna Xu

Mental and cognitive representations are believed to reside on low-dimensional, non-linear manifolds embedded within high-dimensional brain activity. Uncovering these manifolds is key to understanding individual differences in brain…

Machine Learning · Computer Science 2025-05-02 Eloy Geenjaar , Vince Calhoun

Many fMRI analyses examine functional connectivity, or statistical dependencies among remote brain regions. Yet popular methods for studying whole-brain functional connectivity often yield results that are difficult to interpret. Factor…

Methodology · Statistics 2024-09-24 Kyle Stanley , Nicole Lazar , Matthew Reimherr

Functional magnetic resonance imaging (fMRI) enables indirect detection of brain activity changes via the blood-oxygen-level-dependent (BOLD) signal. Conventional analysis methods mainly rely on the real-valued magnitude of these signals.…

Methodology · Statistics 2023-10-31 Zhengxin Wang , Daniel B. Rowe , Xinyi Li , D. Andrew Brown

Bayesian neural networks (BNNs) have recently regained a significant amount of attention in the deep learning community due to the development of scalable approximate Bayesian inference techniques. There are several advantages of using a…

Machine Learning · Statistics 2023-05-02 Aliaksandr Hubin , Geir Storvik
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