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Rare diseases affect hundreds of millions worldwide, yet diagnosis often spans years. Convectional pipelines decouple noisy evidence extraction from downstream inferential diagnosis, and general/medical large language models (LLMs) face…

Large language models (LLMs) have demonstrated impressive capabilities in various reasoning tasks, aided by techniques like chain-of-thought prompting that elicits verbalized reasoning. However, LLMs often generate text with obvious…

Artificial Intelligence · Computer Science 2024-12-06 Zhihui Xie , Jizhou Guo , Tong Yu , Shuai Li

Understanding how the human brain progresses from processing simple linguistic inputs to performing high-level reasoning is a fundamental challenge in neuroscience. While modern large language models (LLMs) are increasingly used to model…

Computation and Language · Computer Science 2026-01-27 Linyang He , Tianjun Zhong , Richard Antonello , Gavin Mischler , Micah Goldblum , Nima Mesgarani

Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis…

Computation and Language · Computer Science 2025-05-21 Kevin Wu , Eric Wu , Rahul Thapa , Kevin Wei , Angela Zhang , Arvind Suresh , Jacqueline J. Tao , Min Woo Sun , Alejandro Lozano , James Zou

Europe's healthcare systems require enhanced interoperability and digitalization, driving a demand for innovative solutions to process legacy clinical data. This paper presents the results of our project, which aims to leverage Large…

Computation and Language · Computer Science 2025-07-09 Aynur Guluzade , Naguib Heiba , Zeyd Boukhers , Florim Hamiti , Jahid Hasan Polash , Yehya Mohamad , Carlos A Velasco

The deployment of large language models (LLMs) faces considerable challenges concerning resource constraints and inference efficiency. Recent research has increasingly focused on smaller, task-specific models enhanced by distilling…

Computation and Language · Computer Science 2024-09-20 Wei Wang , Zhaowei Li , Qi Xu , Yiqing Cai , Hang Song , Qi Qi , Ran Zhou , Zhida Huang , Tao Wang , Li Xiao

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Accurate risk assessment in lung cancer screening is critical for enabling early cancer detection and minimizing unnecessary invasive procedures. The Lung CT Screening Reporting and Data System (Lung-RADS) has been widely used as the…

Machine Learning · Computer Science 2025-09-09 Chuang Niu , Ge Wang

Large language models (LLMs) have recently shown strong progress on scientific reasoning, yet two major bottlenecks remain. First, explicit retrieval fragments reasoning, imposing a hidden "tool tax" of extra tokens and steps. Second,…

Medical image classifiers detect gastrointestinal diseases well, but they do not explain their decisions. Large language models can generate clinical text, yet they struggle with visual reasoning and often produce unstable or incorrect…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Md. Najib Hasan , Imran Ahmad , Sourav Basak Shuvo , Md. Mahadi Hasan Ankon , Sunanda Das , Nazmul Siddique , Hui Wang

Radiology reports capture crucial longitudinal information on tumor burden, treatment response, and disease progression, yet their unstructured narrative format complicates automated analysis. While large language models (LLMs) have…

Computation and Language · Computer Science 2026-03-12 Luc Builtjes , Alessa Hering

Large Language Models (LLMs) have demonstrated strong performance across a wide range of NLP tasks. However, they often exhibit suboptimal behaviors and inconsistencies when exposed to unfamiliar external information, underscoring their…

Computation and Language · Computer Science 2026-01-28 Zhipeng Xu , Zhenghao Liu , Yukun Yan , Shuo Wang , Shi Yu , Zheni Zeng , Chaojun Xiao , Zhiyuan Liu , Ge Yu , Chenyan Xiong

Manual chart review remains an extremely time-consuming and resource-intensive component of clinical research, requiring experts to extract often complex information from unstructured electronic health record (EHR) narratives. We present a…

Machine reasoning has made great progress in recent years owing to large language models (LLMs). In the clinical domain, however, most NLP-driven projects mainly focus on clinical classification or reading comprehension, and under-explore…

Computation and Language · Computer Science 2024-05-13 Taeyoon Kwon , Kai Tzu-iunn Ong , Dongjin Kang , Seungjun Moon , Jeong Ryong Lee , Dosik Hwang , Yongsik Sim , Beomseok Sohn , Dongha Lee , Jinyoung Yeo

Large Language Models (LLMs) have made significant progress in open-ended dialogue, yet their inability to retain and retrieve relevant information from long-term interactions limits their effectiveness in applications requiring sustained…

Large Language Models (LLMs) have shown to be capable of various tasks, yet their capability in interpreting and reasoning over tabular data remains an underexplored area. In this context, this study investigates from three core…

Computation and Language · Computer Science 2023-12-29 Tianyang Liu , Fei Wang , Muhao Chen

The detection of mental health problems from social media and the interpretation of these results have been extensively explored. Research has shown that incorporating clinical symptom information into a model enhances domain expertise,…

Computation and Language · Computer Science 2025-10-28 Hoyun Song , Huije Lee , Jisu Shin , Sukmin Cho , Changgeon Ko , Jong C. Park

The emergence of advanced reasoning capabilities in Large Language Models (LLMs) marks a transformative development in healthcare applications. Beyond merely expanding functional capabilities, these reasoning mechanisms enhance decision…

Artificial Intelligence · Computer Science 2025-08-27 Armin Berger , Sarthak Khanna , David Berghaus , Rafet Sifa

Supervised Fine-Tuning (SFT) of the language backbone plays a pivotal role in adapting Vision-Language Models (VLMs) to specialized domains such as medical reasoning. However, existing SFT practices often rely on unfiltered textual datasets…

Computation and Language · Computer Science 2026-03-17 Xinlin Zhuang , Feilong Tang , Haolin Yang , Xiwei Liu , Ming Hu , Huifa Li , Haochen Xue , Junjun He , Zongyuan Ge , Yichen Li , Ying Qian , Imran Razzak