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A physics-informed machine learning framework based on holomorphic neural networks is introduced for detecting cracks in two-dimensional solids from strain or displacement data. Crack detection is formulated as an inverse problem in which…

Computational Engineering, Finance, and Science · Computer Science 2026-03-16 Jonas Hund , Nicolas Cuenca , Tito Andriollo

The mRNA optimization is critical for therapeutic and biotechnological applications, since sequence features directly govern protein expression levels and efficacy. However, current methods face significant challenges in simultaneously…

Quantitative Methods · Quantitative Biology 2025-06-02 Zheng Gong , Ziyi Jiang , Weihao Gao , Deng Zhuo , Lan Ma

Deep neural networks (DNNs) are vulnerable to adversarial examples and other data perturbations. Especially in safety critical applications of DNNs, it is therefore crucial to detect misclassified samples. The current state-of-the-art…

Machine Learning · Computer Science 2020-04-21 Julia Lust , Alexandru Paul Condurache

Physicians perform minimally invasive percutaneous procedures under Computed Tomography (CT) image guidance both for the diagnosis and treatment of numerous diseases. For these procedures performed within Computed Tomography Scanners,…

Through the probing of light-matter interactions, Raman spectroscopy provides invaluable insights into the composition, structure, and dynamics of materials, and obtaining such data from portable and cheap instruments is of immense…

Chemical Physics · Physics 2024-07-03 Vikas Yadav , Abhay Kumar Tiwari , Soumik Siddhanta

The general trace reconstruction problem seeks to recover an original sequence from its noisy copies independently corrupted by deletions, insertions, and substitutions. This problem arises in applications such as DNA data storage, a…

Machine Learning · Computer Science 2025-07-18 Franziska Weindel , Michael Girsch , Reinhard Heckel

Raman spectroscopy is a powerful analytical tool with applications ranging from quality control to cutting edge biomedical research. One particular area which has seen tremendous advances in the past decade is the development of powerful…

Signal Processing · Electrical Eng. & Systems 2020-06-19 M. Hamed Mozaffari , Li-Lin Tay

Oxford Nanopore MinION sequencer is currently the smallest sequencing device available. While being able to produce very long reads (reads of up to 100~kbp were reported), it is prone to high sequencing error rates of up to 30%. Since most…

Data Structures and Algorithms · Computer Science 2016-06-29 Rastislav Rabatin , Broňa Brejová , Tomáš Vinař

Heterogeneous information networks (HINs) can be used to model various real-world systems. As HINs consist of multiple types of nodes, edges, and node features, it is nontrivial to directly apply graph neural network (GNN) techniques in…

Machine Learning · Computer Science 2025-01-15 Zhaoqing Li , Maiqi Jiang , Shengyuan Chen , Bo Li , Guorong Chen , Xiao Huang

Artificial neural networks (NNs) can be implemented using chemical reaction networks (CRNs), where the concentrations of species act as inputs and outputs. In such biochemical computing, noise-robust computing is crucial due to the…

Molecular Networks · Quantitative Biology 2024-10-17 Sunghwa Kang , Jinsu Kim

The advent of DNA and RNA sequencing has revolutionized the study of genomics and molecular biology. Next generation sequencing (NGS) technologies like Illumina, Ion Torrent, SOLiD sequencing etc. have brought about a quick and cheap way to…

Genomics · Quantitative Biology 2021-03-26 Yun Heo , Gowthami Manikandan , Anand Ramachandran , Deming Chen

Many semantic video analysis tasks can benefit from multiple, heterogenous signals. For example, in addition to the original RGB input sequences, sequences of optical flow are usually used to boost the performance of human action…

Computer Vision and Pattern Recognition · Computer Science 2019-03-27 Lin Sun , Kui Jia , Yuejia Shen , Silvio Savarese , Dit Yan Yeung , Bertram E. Shi

Unsupervised industrial anomaly detection requires accurately identifying defects without labeled data. Traditional autoencoder-based methods often struggle with incomplete anomaly suppression and loss of fine details, as their single-pass…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Rongcheng Wu , Hao Zhu , Shiying Zhang , Mingzhe Wang , Zhidong Li , Hui Li , Jianlong Zhou , Jiangtao Cui , Fang Chen , Pingyang Sun , Qiyu Liao , Ye Lin

Raman spectroscopy is a powerful and non-invasive method for analysis of chemicals and detection of unknown substances. However, Raman signal is so weak that background noise can distort the actual Raman signal. These baseline shifts that…

Signal Processing · Electrical Eng. & Systems 2021-04-28 M. Hamed Mozaffari , Li-Lin Tay

Deep learning-based histopathology image classification is a key technique to help physicians in improving the accuracy and promptness of cancer diagnosis. However, the noisy labels are often inevitable in the complex manual annotation…

Image and Video Processing · Electrical Eng. & Systems 2021-12-08 Chuang Zhu , Wenkai Chen , Ting Peng , Ying Wang , Mulan Jin

High-density polyethylene (HDPE) is used in applications ranging from cooling water pipelines in nuclear power plants and distribution pipelines for natural gas and hydrogen to biomedical implants. Embedded crack-like flaws form within HDPE…

Materials Science · Physics 2024-06-11 Sijun Niu , Venkatsai Bellala , Daanish A. Qureshi , Vikas Srivastava

Proteins are the active working horses in our body. These biomolecules perform all vital cellular functions from DNA replication and general biosynthesis to metabolic signaling and environmental sensing. While static 3D structures are now…

Quantitative Methods · Quantitative Biology 2020-10-16 Sonja Schmid , Cees Dekker

In chemical processing and bioprocessing, conventional online sensors are limited to measure only basic process variables like pressure and temperature, pH, dissolved O and CO$_2$ and viable cell density (VCD). The concentration of other…

Quantitative Methods · Quantitative Biology 2020-05-07 Semion Rozov

Designing an optimal deep neural network for a given task is important and challenging in many machine learning applications. To address this issue, we introduce a self-adaptive algorithm: the adaptive network enhancement (ANE) method,…

Numerical Analysis · Mathematics 2022-03-02 Zhiqiang Cai , Jingshuang Chen , Min Liu
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