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Automated white blood cell (WBC) classification is essential for leukemia screening but remains challenged by extreme class imbalance, long-tail distributions, and domain shift, leading deep models to overfit dominant classes and fail on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Duc T. Nguyen , Hoang-Long Nguyen , Huy-Hieu Pham

Automated white blood cell (WBC) classification is essential for scalable leukaemia screening. However, real-world deployment is challenged by domain shifts caused by staining protocols, scanner characteristics, and inter-laboratory…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Ruyi Dai , Tingkwong Ng , Hao Chen

We present WBCBench 2026, an ISBI challenge and benchmark for automated WBC classification designed to stress-test algorithms under three key difficulties: (i) severe class imbalance across 13 morphologically fine-grained WBC classes, (ii)…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Xin Tian , Xudong Ma , Tianqi Yang , Alin Achim , Bartłomiej W Papież , Phandee Watanaboonyongcharoen , Nantheera Anantrasirichai

White blood cell (WBC) classification is fundamental for hematology applications such as infection assessment, leukemia screening, and treatment monitoring. However, real-world WBC datasets present substantial appearance variations caused…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Luu Le , Hoang-Loc Cao , Ha-Hieu Pham , Thanh-Huy Nguyen , Ulas Bagci

White blood cells (WBC) are important parts of our immune system, and they protect our body against infections by eliminating viruses, bacteria, parasites and fungi. The number of WBC types and the total number of WBCs provide important…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Sibasish Dhibar

Accurate morphological classification of white blood cells (WBCs) is an important step in the diagnosis of leukemia, a disease in which nonfunctional blast cells accumulate in the bone marrow. Recently, deep convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Rao Muhammad Umer , Armin Gruber , Sayedali Shetab Boushehri , Christian Metak , Carsten Marr

Leukemia (blood cancer) is an unusual spread of White Blood Cells or Leukocytes (WBCs) in the bone marrow and blood. Pathologists can diagnose leukemia by looking at a person's blood sample under a microscope. They identify and categorize…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Mohammad Zolfaghari , Hedieh Sajedi

Automating white blood cell classification for diagnosis of leukaemia is a promising alternative to time-consuming and resource-intensive examination of cells by expert pathologists. However, designing robust algorithms for classification…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Siddharth Srivastava , Adam Smith , Scott Brooks , Jack Bacon , Till Bretschneider

Accurate classification of white blood cells in peripheral blood is essential for diagnosing hematological diseases. Due to constantly evolving clinical settings, data sources, and disease classifications, it is necessary to update machine…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Ario Sadafi , Raheleh Salehi , Armin Gruber , Sayedali Shetab Boushehri , Pascal Giehr , Nassir Navab , Carsten Marr

Accurately and quickly binuclear cell (BC) detection plays a significant role in predicting the risk of leukemia and other malignant tumors. However, manual microscopy counting is time-consuming and lacks objectivity. Moreover, with the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-29 Baomin Wang , Geng Hu , Dan Chen , Lihua Hu , Cheng Li , Yu An , Guiping Hu , Guang Jia

White blood cell (WBC) classification assists in assessing immune health and diagnosing various diseases, yet manual classification is labor-intensive and prone to inconsistencies. Recent advancements in deep learning have shown promise…

Human immune system contains white blood cells (WBC) that are good indicator of many diseases like bacterial infections, AIDS, cancer, spleen, etc. White blood cells have been sub classified into four types: monocytes, lymphocytes,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Rabia Asghar , Arslan Shaukat , Usman Akram , Rimsha Tariq

White blood cell (WBC) classification plays a vital role in hematology for diagnosing various medical conditions. However, it faces significant challenges due to domain shifts caused by variations in sample sources (e.g., blood or bone…

Machine learning (ML) and deep learning (DL) models have been employed to significantly improve analyses of medical imagery, with these approaches used to enhance the accuracy of prediction and classification. Model predictions and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Rabia Asghar , Sanjay Kumar , Paul Hynds , Arslan Shaukat

Earlier diagnosis of Leukemia can save thousands of lives annually. The prognosis of leukemia is challenging without the morphological information of White Blood Cells (WBC) and relies on the accessibility of expensive microscopes and the…

Image and Video Processing · Electrical Eng. & Systems 2024-05-20 Abdul Rehman , Talha Meraj , Aiman Mahmood Minhas , Ayisha Imran , Mohsen Ali , Waqas Sultani

Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Saqib Nazir , Ardhendu Behera

The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are…

Recently, a lot of automated white blood cells (WBC) or leukocyte classification techniques have been developed. However, all of these methods only utilize a single modality microscopic image i.e. either blood smear or fluorescence based,…

Image and Video Processing · Electrical Eng. & Systems 2022-08-18 Litao Yang , Deval Mehta , Dwarikanath Mahapatra , Zongyuan Ge

A mutation in the DNA of a single cell that compromises its function initiates leukemia,leading to the overproduction of immature white blood cells that encroach upon the space required for the generation of healthy blood cells.Leukemia is…

Computer Vision and Pattern Recognition · Computer Science 2025-01-27 Md. Abu Ahnaf Mollick , Md. Mahfujur Rahman , D. M. Asadujjaman , Abdullah Tamim , Nosin Anjum Dristi , Md. Takbir Hossen

The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Sai Sukruth Bezugam
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