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One of the basic aims in science is to unravel the chain of cause and effect of particular systems. Especially for large systems this can be a daunting task. Detailed interventional and randomized data sampling approaches can be used to…

Methodology · Statistics 2016-11-30 Seyed Mahdi Mahmoudi , Ernst Wit

Mendelian randomization (MR) is widely used to uncover causal relationships in the presence of unmeasured confounders. However, most existing MR methods presuppose linear causality, risking bias when the true relationships are nonlinear,…

Methodology · Statistics 2025-08-05 Xinpei Wang , Tao Huang , Jinzhu Jia

Covariate adjustment is one method of causal effect identification in non-experimental settings. Prior research provides routes for finding appropriate adjustments sets, but much of this research assumes knowledge of the underlying causal…

Methodology · Statistics 2025-08-04 Sara LaPlante , Sofia Triantafillou , Emilija Perković

The relationship between statistical dependency and causality lies at the heart of all statistical approaches to causal inference. Recent results in the ChaLearn cause-effect pair challenge have shown that causal directionality can be…

Machine Learning · Computer Science 2014-12-22 Gianluca Bontempi , Maxime Flauder

Discovering causal relations among observed variables in a given data set is a main topic in studies of statistics and artificial intelligence. Recently, some techniques to discover an identifiable causal structure have been explored based…

Machine Learning · Computer Science 2012-02-20 Takanori Inazumi , Takashi Washio , Shohei Shimizu , Joe Suzuki , Akihiro Yamamoto , Yoshinobu Kawahara

We provide a unified operational framework for the study of causality, non-locality and contextuality, in a fully device-independent and theory-independent setting. We define causaltopes, our chosen portmanteau of "causal polytopes", for…

Quantum Physics · Physics 2023-07-31 Stefano Gogioso , Nicola Pinzani

Identifying and controlling bias is a key problem in empirical sciences. Causal diagram theory provides graphical criteria for deciding whether and how causal effects can be identified from observed (nonexperimental) data by covariate…

Artificial Intelligence · Computer Science 2012-02-20 Johannes Textor , Maciej Liskiewicz

Most existing causal structure learning methods assume data collected from one environment and independent and identically distributed (i.i.d.). In some cases, data are collected from different subjects from multiple environments, which…

Machine Learning · Computer Science 2023-02-07 Wei Chen , Yunjin Wu , Ruichu Cai , Yueguo Chen , Zhifeng Hao

Causality has traditionally been a scientific way to generate knowledge by relating causes to effects. From an imaginery point of view, causal graphs are a helpful tool for representing and infering new causal information. In previous…

Artificial Intelligence · Computer Science 2020-02-07 Eduardo C. Garrido-Merchán , C. Puente , A. Sobrino , J. A. Olivas

Causal understanding is important in many disciplines of science and engineering, where we seek to understand how different factors in the system causally affect an experiment or situation and pave a pathway towards creating effective or…

Robotics · Computer Science 2025-05-14 Miguel Arana-Catania , Weisi Guo

The inaccessibility of controlled randomized trials due to inherent constraints in many fields of science has been a fundamental issue in causal inference. In this paper, we focus on distinguishing the cause from effect in the bivariate…

Machine Learning · Statistics 2021-02-23 Jean-Francois Ton , Dino Sejdinovic , Kenji Fukumizu

Emergence and causality are two fundamental concepts for understanding complex systems. They are interconnected. On one hand, emergence refers to the phenomenon where macroscopic properties cannot be solely attributed to the cause of…

Physics and Society · Physics 2024-02-27 Bing Yuan , Zhang Jiang , Aobo Lyu , Jiayun Wu , Zhipeng Wang , Mingzhe Yang , Kaiwei Liu , Muyun Mou , Peng Cui

Self-organizing systems demonstrate how simple local rules can generate complex stochastic patterns. Many natural systems rely on such dynamics, making self-organization central to understanding natural complexity. A fundamental challenge…

Adaptation and Self-Organizing Systems · Physics 2026-01-12 Elias Najarro , Nicolas Bessone , Sebastian Risi

Bivariate structural causal models (SCM) are often used to infer causal direction by examining their goodness-of-fit under restricted model classes. In this paper, we describe a parametrization of bivariate SCMs in terms of a causal…

Machine Learning · Statistics 2025-06-11 Johnny Xi , Hugh Dance , Peter Orbanz , Benjamin Bloem-Reddy

We design a new nonparametric method that allows one to estimate the matrix of integrated kernels of a multivariate Hawkes process. This matrix not only encodes the mutual influences of each nodes of the process, but also disentangles the…

Machine Learning · Statistics 2017-05-31 Massil Achab , Emmanuel Bacry , Stéphane Gaïffas , Iacopo Mastromatteo , Jean-Francois Muzy

We propose a nonparametric method for detecting nonlinear causal relationship within a set of multidimensional discrete time series, by using sparse additive models (SpAMs). We show that, when the input to the SpAM is a $\beta$-mixing time…

Machine Learning · Statistics 2018-04-27 Yingxiang Yang , Adams Wei Yu , Zhaoran Wang , Tuo Zhao

Controlling false positives (Type I errors) through statistical hypothesis testing is a foundation of modern scientific data analysis. Existing causal structure discovery algorithms either do not provide Type I error control or cannot scale…

Methodology · Statistics 2025-12-29 James Leiner , Brian Manzo , Aaditya Ramdas , Wesley Tansey

Identifying causal relationships is a challenging yet crucial problem in many fields of science like epidemiology, climatology, ecology, genomics, economics and neuroscience, to mention only a few. Recent studies have demonstrated that…

To draw scientifically meaningful conclusions and build reliable models of quantitative phenomena, cause and effect must be taken into consideration (either implicitly or explicitly). This is particularly challenging when the measurements…

Machine Learning · Computer Science 2020-12-11 Max A. Little , Reham Badawy

Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

Machine Learning · Computer Science 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola