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We present a proof-of-principle study demonstrating the use of large language model (LLM) agents to automate a representative high energy physics (HEP) analysis. Using the Higgs boson diphoton cross-section measurement as a case study with…

Data Analysis, Statistics and Probability · Physics 2025-12-10 Eli Gendreau-Distler , Joshua Ho , Dongwon Kim , Luc Tomas Le Pottier , Haichen Wang , Chengxi Yang

The field of high-energy physics (HEP), along with many scientific disciplines, is currently experiencing a dramatic influx of new methodologies powered by modern machine learning techniques. Over the last few years, a growing body of HEP…

High Energy Physics - Phenomenology · Physics 2019-10-22 Benjamin Nachman , Chase Shimmin

Recent advances in agentic AI have enabled increasingly autonomous workflows, but existing systems still face substantial challenges in achieving reliable deployment in real-world scientific research. In this work, we present a safe,…

Artificial Intelligence · Computer Science 2026-04-16 Qibin Liu , Julia Gonski

Modern searches for physics beyond the Standard Model produce rapidly expanding literature containing heterogeneous information, including textual analyses, numerical datasets, and graphical exclusion limits. Integrating these distributed…

High Energy Physics - Experiment · Physics 2026-05-05 Altan Cakir , Ayca Yerlikaya

We present an AI agentic measurement of the thrust distribution in $e^{+}e^{-}$ collisions at $\sqrt{s}=91.2$~GeV using archived ALEPH data. The analysis and all note writing is carried out entirely by AI agents (OpenAI Codex and Anthropic…

High Energy Physics - Experiment · Physics 2026-04-02 Anthony Badea , Yi Chen , Marcello Maggi , Yen-Jie Lee , Electron-Positron Alliance

High-energy physics (HEP) provides ever-growing amount of data. To analyse these, continuously-evolving computational power is required in parallel by extending the storage capacity. Such developments play key roles in the future of this…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-03-10 Gábor Bíró , Gergely Gábor Barnaföldi , Péter Lévai

Agentic systems, in which diverse agents cooperate to tackle challenging problems, are exploding in popularity in the AI community. However, existing agentic frameworks take a relatively narrow view of agents, apply a centralized model, and…

Multiagent Systems · Computer Science 2026-01-30 Alok Kamatar , J. Gregory Pauloski , Yadu Babuji , Ryan Chard , Mansi Sakarvadia , Daniel Babnigg , Kyle Chard , Ian Foster

We present the first implementation of AI agents into the design and optimization of detectors in high-energy physics experiments via a bilevel optimization framework that vertically integrates detector geometry, front-end digitization, and…

Instrumentation and Detectors · Physics 2026-04-24 Wonyong Chung , Qibin Liu , Liangyu Wu , Julia Gonski

Artificial Intelligence (AI) is rapidly transforming scientific research and has become central to many data-intensive disciplines. High Energy Physics (HEP), with its vast data volumes, complex theoretical structures, and precision-driven…

High Energy Physics - Phenomenology · Physics 2026-05-06 Tianji Cai , Ke Li , Teng Li

High Energy Physics (HEP) experiments like BESIII produce petabyte-scale data. Extracting physics results requires complex workflows (simulation, reconstruction, statistical analysis, etc.) that traditionally take experts months or years.…

We present the first language-model-driven agentic artificial intelligence (AI) system to autonomously execute multi-stage physics experiments on a production synchrotron light source. Implemented at the Advanced Light Source particle…

Accelerator Physics · Physics 2026-04-28 Thorsten Hellert , Drew Bertwistle , Simon C. Leemann , Antonin Sulc , Marco Venturini

Autonomous language-model agents are increasingly evaluated on long-horizon tool-use tasks, but existing benchmarks rarely capture the complexity and nuance of real scientific work. To address this gap, we introduce Collider-Bench, a…

Machine Learning · Computer Science 2026-05-15 Darius A. Faroughy , Sofia Palacios Schweitzer , Ian Pang , Siddharth Mishra-Sharma , David Shih

This paper details two novel frameworks for developing autonomous, agentic AI in scientific workflows. Both systems leverage a hybrid Local Body, Remote Brain architecture via Google Colab, utilizing Python-based local orchestrators to…

Artificial Intelligence · Computer Science 2026-05-27 Judy Fox , Geoffrey Fox

Automated Theorem Proving (ATP) faces challenges due to its complexity and computational demands. Recent work has explored using Large Language Models (LLMs) for ATP action selection, but these methods can be resource-intensive. This study…

Artificial Intelligence · Computer Science 2024-07-23 Mahdi Buali , Robert Hoehndorf

LLM-based reasoning models have enabled the development of agentic systems that act as co-scientists, assisting in multi-step scientific analysis. However, evaluating these systems is challenging, as it requires realistic, end-to-end…

Machine Learning · Computer Science 2026-02-24 Siba Smarak Panigrahi , Jovana Videnović , Maria Brbić

Large language models (LLMs) are catalyzing the development of autonomous AI research agents for scientific and engineering discovery. We present FM Agent, a novel and general-purpose multi-agent framework that leverages a synergistic…

Modern science is reaching a critical inflection point. Instruments across disciplines, from particle physics and astronomy to genomics and climate modeling, now produce data of such scale, diversity, and interdependence that traditional…

High Energy Physics - Experiment · Physics 2026-03-10 Ke Li , Beijiang Liu , Bruce Mellado , Changzheng Yuan , Zhengde Zhang

Large Language Models (LLMs) are rapidly advancing across diverse domains, yet their application in theoretical physics remains inadequate. While current models show competence in mathematical reasoning and code generation, we identify…

Computation and Language · Computer Science 2026-03-13 Sirui Lu , Zhijing Jin , Terry Jingchen Zhang , Pavel Kos , J. Ignacio Cirac , Bernhard Schölkopf

The automation of scientific discovery represents a critical milestone in Artificial Intelligence (AI) research. However, existing agentic systems for science suffer from two fundamental limitations: rigid, pre-programmed workflows that…

Artificial Intelligence · Computer Science 2025-10-20 Ed Li , Junyu Ren , Xintian Pan , Cat Yan , Chuanhao Li , Dirk Bergemann , Zhuoran Yang

Finite element (FE) analysis guides the design and verification of nearly all manufactured objects. It is at the core of computational engineering, enabling simulation of complex physical systems, from fluids and solids to multiphysics…

Computational Engineering, Finance, and Science · Computer Science 2026-04-15 Rushikesh Deotale , Adithya Srinivasan , Yuan Tian , Tianyi Zhang , Pavlos Vlachos , Hector Gomez
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