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A central problem in systems neuroscience is to determine how an external stimulation is propagated through the brain so as to produce a reaction. Current deterministic and stochastic control models quantify transition costs between brain…

Optimization and Control · Mathematics 2026-03-23 Cristian Mendico

Understanding the dynamic reorganization of brain networks is critical for predicting cognitive decline, neurological progression, and individual variability in clinical outcomes. This work proposes a multimodal graph neural network…

Machine Learning · Computer Science 2026-02-11 Preksha Girish , Rachana Mysore , Kiran K. N. , Hiranmayee R. , Shipra Prashanth , Shrey Kumar

We study multi-marginal optimal transport problems from a probabilistic graphical model perspective. We point out an elegant connection between the two when the underlying cost for optimal transport allows a graph structure. In particular,…

Optimization and Control · Mathematics 2020-06-26 Isabel Haasler , Rahul Singh , Qinsheng Zhang , Johan Karlsson , Yongxin Chen

The paper introduces a biologically and evolutionarily plausible neural architecture that allows a single group of neurons, or an entire cortical pathway, to be dynamically reconfigured to perform multiple, potentially very different…

Neural and Evolutionary Computing · Computer Science 2015-08-13 Thomas M. Breuel

We propose a unified framework for adaptive routing in multitask, multimodal prediction settings where data heterogeneity and task interactions vary across samples. Motivated by applications in psychotherapy where structured assessments and…

The branched transport problem, a popular recent variant of optimal transport, is a non-convex and non-smooth variational problem on Radon measures. The so-called urban planning problem, on the contrary, is a shape optimization problem that…

Optimization and Control · Mathematics 2022-06-15 Julius Lohmann , Bernhard Schmitzer , Benedikt Wirth

This article generalizes the study of branched/ramified optimal transportation to those with capacity constraints. Each admissible transport network studied here is represented by a transport multi-path between measures, with a capacity…

Optimization and Control · Mathematics 2024-02-13 Qinglan Xia , Haotian Sun

A prominent model for transportation networks is branched transport, which seeks the optimal transportation scheme to move material from a given initial to a final distribution. The cost of the scheme encodes a higher transport efficiency…

Classical Analysis and ODEs · Mathematics 2020-09-04 Alessio Brancolini , Benedikt Wirth

Entropy regularized optimal transport and its multi-marginal generalization have attracted increasing attention in various applications, in particular due to efficient Sinkhorn-like algorithms for computing optimal transport plans. However,…

Optimization and Control · Mathematics 2023-01-25 Florian Beier , Johannes von Lindheim , Sebastian Neumayer , Gabriele Steidl

A multivariate distribution can be described by a triangular transport map from the target distribution to a simple reference distribution. We propose Bayesian nonparametric inference on the transport map by modeling its components using…

Methodology · Statistics 2023-01-18 Matthias Katzfuss , Florian Schäfer

Migratory and tissue resident cells exhibit highly branched morphologies to perform their function and to adapt to the microenvironment. Immune cells, for example, display transient branched shapes while exploring the surrounding tissues.…

Biological Physics · Physics 2024-04-02 Jiayi Liu , Javier Boix-Campos , Jonathan E. Ron , Johan M. Kux , Nir S. Gov , Pablo J. Sáez

Cells and organisms follow aligned structures in their environment, a process that can generate persistent migration paths. Kinetic transport equations are a popular modelling tool for describing biological movements at the mesoscopic…

Cell Behavior · Quantitative Biology 2021-01-13 Nadia Loy , Thomas Hillen , Kevin John Painter

We investigate the transportation cost-information inequalities for bifurcating Markov chains which are a class of processes indexed by binary tree. These processes provide models for cell growth when each individual in one generation gives…

Probability · Mathematics 2015-01-28 Siméon Valère Bitseki Penda , Mikael Escobar-Bach , Arnaud Guillin

Communication of signals among nodes in a complex network poses fundamental problems of efficiency and cost. Routing of messages along shortest paths requires global information about the topology, while spreading by diffusion, which…

Neurons and Cognition · Quantitative Biology 2019-06-19 Andrea Avena-Koenigsberger , Xiaoran Yan , Artemy Kolchinsky , Martijn van den Heuvel , Patric Hagmann , Olaf Sporns

In this paper, we consider the problem of recovering a graph that represents the statistical data dependency among nodes for a set of data samples generated by nodes, which provides the basic structure to perform an inference task, such as…

Machine Learning · Statistics 2018-05-01 Hyeryung Jang , HyungSeok Song , Yung Yi

Transport networks are crucial for the functioning of natural and technological systems. We study a mathematical model of vascular network adaptation, where the network structure dynamically adjusts to changes in blood flow and pressure.…

Adaptation and Self-Organizing Systems · Physics 2023-06-01 Konstantin Klemm , Erik Andreas Martens

Mathematical network models are extremely useful to capture complex propagation processes between different regions (nodes), for example the spread of an infectious agent between different countries, or the transport and replication of…

Biological Physics · Physics 2026-04-10 Hadrien Oliveri , Emilia Cozzolino , Alain Goriely

We develop a new framework for branched transport between probability measures which are allowed to vary in time. This framework can be used to model problems where the underlying transportation network displays a branched structure, but…

Optimization and Control · Mathematics 2025-12-25 Jun Kitagawa , Cecilia Mikat

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon
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