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Leveraging on the underlying low-dimensional structure of data, low-rank and sparse modeling approaches have achieved great success in a wide range of applications. However, in many applications the data can display structures beyond simply…

Machine Learning · Computer Science 2019-12-04 Zhao Kang , Xiao Lu , Yiwei Lu , Chong Peng , Zenglin Xu

The non-uniform sampling is a powerful approach to enable fast acquisition but requires sophisticated reconstruction algorithms. Faithful reconstruction from partial sampled exponentials is highly expected in general signal processing and…

We present a new approach to 3D object representation where a neural network encodes the geometry of an object directly into the weights and biases of a second 'mapping' network. This mapping network can be used to reconstruct an object by…

Machine Learning · Computer Science 2020-04-07 Eric Mitchell , Selim Engin , Volkan Isler , Daniel D Lee

Structure-informed protein representation learning is essential for effective protein function annotation and \textit{de novo} design. However, the presence of inherent noise in both crystal and AlphaFold-predicted structures poses…

Biomolecules · Quantitative Biology 2025-03-25 Zhongyue Zhang , Runze Ma , Yanjie Huang , Shuangjia Zheng

DNA is a promising medium for digital information storage for its exceptional density and durability. While prior studies advanced coding theory, workflow design, and simulation tools, challenges such as synthesis costs, sequencing errors,…

Emerging Technologies · Computer Science 2025-10-06 Rakesh Thakur , Lavanya Singh , Yashika , Manomay Bundawala , Aruna Kumar

In this paper, we propose a re-weighted elastic net (REN) model for biometric recognition. The new model is applied to data separated into geometric and color spatial components. The geometric information is extracted using a fast cartoon -…

Computer Vision and Pattern Recognition · Computer Science 2015-07-28 Juan C. Moreno , V. B. S. Prasath , Gil Santos , Hugo Proenca

Large vision models based in deep learning architectures have been consistently advancing the state-of-the-art in biometric recognition. However, three weaknesses are commonly reported for such kind of approaches: 1) their extreme demands…

Computer Vision and Pattern Recognition · Computer Science 2024-06-27 Henrique Jesus , Hugo Proença

In many scenarios, especially biomedical applications, the correct delineation of complex fine-scaled structures such as neurons, tissues, and vessels is critical for downstream analysis. Despite the strong predictive power of deep learning…

Computer Vision and Pattern Recognition · Computer Science 2024-03-25 Xiaoling Hu

Branched molecules of deoxyribonucleic acid (DNA) can self-assemble into nanostructures through complementary cohesive strand base pairing. The production of DNA nanostructures is valuable in targeted drug delivery and biomolecular…

Combinatorics · Mathematics 2022-03-15 D. Chloe Griffin , Jessica Sorrells

RGB-D semantic segmentation methods conventionally use two independent encoders to extract features from the RGB and depth data. However, there lacks an effective fusion mechanism to bridge the encoders, for the purpose of fully exploiting…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Liuyuan Deng , Ming Yang , Tianyi Li , Yuesheng He , Chunxiang Wang

Retrieving or generating two-dimensional molecular structures on the basis of vibrational spectra has been well demonstrated via deep learning models. However, deciphering three-dimensional molecular conformations is still challenging,…

Chemical Physics · Physics 2026-04-28 Xin-Yu Lu , De-Yi Lin , Tong Zhu , Bin Ren , Hao Ma , Guo-Kun Liu

DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural rigidity and…

Soft Condensed Matter · Physics 2019-01-30 Ryan A. Brady , William T. Kaufhold , Nicholas J. Brooks , Vito Foderà , Lorenzo Di Michele

We introduce a reversible deep learning model for 13C NMR that uses a single conditional invertible neural network for both directions between molecular structures and spectra. The network is built from i-RevNet style bijective blocks, so…

Machine Learning · Computer Science 2026-04-24 Stefan Kuhn , Vandana Dwarka , Przemyslaw Karol Grenda , Eero Vainikko

We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure find a sequence that has that structure as its ground state. If such a sequence exists, the structure is called…

Biological Physics · Physics 2015-06-26 Bernd Burghardt , Alexander K. Hartmann

Recent advances in generative models, particularly diffusion and auto-regressive models, have revolutionized fields like computer vision and natural language processing. However, their application to structure-based drug design (SBDD)…

Machine Learning · Computer Science 2025-07-29 Yi He , Ailun Wang , Zhi Wang , Yu Liu , Xingyuan Xu , Wen Yan

Representation learning is at the heart of what makes deep learning effective. In this work, we introduce a new framework for representation learning that we call "Holographic Neural Architectures" (HNAs). In the same way that an observer…

Machine Learning · Statistics 2018-06-05 Tariq Daouda , Jeremie Zumer , Claude Perreault , Sébastien Lemieux

Graph neural networks (GNNs) have emerged as powerful tools for learning protein structures by capturing spatial relationships at the residue level. However, existing GNN-based methods often face challenges in learning multiscale…

Machine Learning · Computer Science 2026-02-03 Shih-Hsin Wang , Yuhao Huang , Taos Transue , Justin Baker , Jonathan Forstater , Thomas Strohmer , Bao Wang

Rising costs in recent years of developing new drugs and treatments have led to extensive research in optimization techniques in biomolecular design. Currently, the most widely used approach in biomolecular design is directed evolution,…

Machine Learning · Computer Science 2021-11-09 Alexander Whatley , Zhekun Luo , Xiangru Tang

Within the field of instance segmentation, most of the state-of-the-art deep learning networks rely nowadays on cascade architectures, where multiple object detectors are trained sequentially, re-sampling the ground truth at each step. This…

Computer Vision and Pattern Recognition · Computer Science 2022-06-22 Leonardo Rossi , Akbar Karimi , Andrea Prati

Depth completion deals with the problem of recovering dense depth maps from sparse ones, where color images are often used to facilitate this task. Recent approaches mainly focus on image guided learning frameworks to predict dense depth.…

Computer Vision and Pattern Recognition · Computer Science 2022-07-14 Zhiqiang Yan , Kun Wang , Xiang Li , Zhenyu Zhang , Jun Li , Jian Yang