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A crucial aspect of managing a public health crisis is to effectively balance prevention and mitigation strategies, while taking their socio-economic impact into account. In particular, determining the influence of different…

Epidemics such as COVID-19 pose serious threats to public health and our society, and it is critical to investigate effective methods to control the spread of epidemics over networks. Prior works on epidemic control often assume complete…

Artificial Intelligence · Computer Science 2023-10-13 Wenxiang Dong , Zhanjiang Chen , H. Vicky Zhao

Achieving safe and coordinated behavior in dynamic, constraint-rich environments remains a major challenge for learning-based control. Pure end-to-end learning often suffers from poor sample efficiency and limited reliability, while…

Systems and Control · Electrical Eng. & Systems 2025-10-10 Max Studt , Georg Schildbach

Containment of epidemic outbreaks entails great societal and economic costs. Cost-effective containment strategies rely on efficiently identifying infected individuals, making the best possible use of the available testing resources.…

Populations and Evolution · Quantitative Biology 2020-12-01 Laura Natali , Saga Helgadottir , Onofrio M. Marago , Giovanni Volpe

Restless multi-armed bandits (RMABs) provide a scalable framework for sequential decision-making under uncertainty, but classical formulations assume binary actions and a single global budget. Real-world settings, such as healthcare, often…

Machine Learning · Computer Science 2025-10-28 Himadri S. Pandey , Kai Wang , Gian-Gabriel P. Garcia

Combating an epidemic entails finding a plan that describes when and how to apply different interventions, such as mask-wearing mandates, vaccinations, school or workplace closures. An optimal plan will curb an epidemic with minimal loss of…

Machine Learning · Computer Science 2023-06-08 Anh Mai , Nikunj Gupta , Azza Abouzied , Dennis Shasha

Although High Performance Computing (HPC) users understand basic resource requirements such as the number of CPUs and memory limits, internal infrastructural utilization data is exclusively leveraged by cluster operators, who use it to…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-19 Abel Souza , Kristiaan Pelckmans , Johan Tordsson

Appropriate medication dosages in the intensive care unit (ICU) are critical for patient survival. Heparin, used to treat thrombosis and inhibit blood clotting in the ICU, requires careful administration due to its complexity and…

Machine Learning · Computer Science 2025-12-09 Yooseok Lim , Inbeom Park , Sujee Lee

Non-pharmaceutical interventions (NPIs) are crucial for controlling pandemics, but existing research often overlooks the heterogeneity of individual behavior, which can lead to inaccurate evaluations of the effectiveness of strategies. In…

Physics and Society · Physics 2026-03-09 Xihan Zhang , Yuqing Liu , Chen Zhao , Guijun Li

Facing a global epidemic of new infectious diseases such as COVID-19, non-pharmaceutical interventions (NPIs), which reduce transmission rates without medical actions, are being implemented around the world to mitigate spreads. One of the…

Populations and Evolution · Quantitative Biology 2021-03-04 Naoya Fujiwara , Tomokatsu Onaga , Takayuki Wada , Shouhei Takeuchi , Junji Seto , Tomoki Nakaya , Kazuyuki Aihara

We study how to effectively leverage expert feedback to learn sequential decision-making policies. We focus on problems with sparse rewards and long time horizons, which typically pose significant challenges in reinforcement learning. We…

Machine Learning · Computer Science 2018-06-12 Hoang M. Le , Nan Jiang , Alekh Agarwal , Miroslav Dudík , Yisong Yue , Hal Daumé

Nonlinear optimal control problems are often solved with numerical methods that require knowledge of system's dynamics which may be difficult to infer, and that carry a large computational cost associated with iterative calculations. We…

Machine Learning · Computer Science 2019-03-08 Ekaterina Abramova , Luke Dickens , Daniel Kuhn , Aldo Faisal

Budget planning and maintenance optimization are crucial for infrastructure asset management, ensuring cost-effectiveness and sustainability. However, the complexity arising from combinatorial action spaces, diverse asset deterioration,…

Artificial Intelligence · Computer Science 2025-07-28 Amir Fard , Arnold X. -X. Yuan

This paper introduces a novel data-driven hierarchical control scheme for managing a fleet of nonlinear, capacity-constrained autonomous agents in an iterative environment. We propose a control framework consisting of a high-level dynamic…

Robotics · Computer Science 2024-04-12 Charlott Vallon , Alessandro Pinto , Bartolomeo Stellato , Francesco Borrelli

This work presents a Hierarchical Multi-Agent Reinforcement Learning framework for analyzing simulated air combat scenarios involving heterogeneous agents. The objective is to identify effective Courses of Action that lead to mission…

Artificial Intelligence · Computer Science 2025-05-15 Ardian Selmonaj , Oleg Szehr , Giacomo Del Rio , Alessandro Antonucci , Adrian Schneider , Michael Rüegsegger

The outbreak of COVID-19 has highlighted the intricate interplay between public health and economic stability on a global scale. This study proposes a novel reinforcement learning framework designed to optimize health and economic outcomes…

Machine Learning · Computer Science 2024-05-01 Maeghal Jain , Ziya Uddin , Wubshet Ibrahim

In the absence of drugs and vaccines, policymakers use non-pharmaceutical interventions such as social distancing to decrease rates of disease-causing contact, with the aim of reducing or delaying the epidemic peak. These measures carry…

Populations and Evolution · Quantitative Biology 2021-04-22 Dylan H. Morris , Fernando W. Rossine , Joshua B. Plotkin , Simon A. Levin

This paper considers the problem of designing non-pharmaceutical intervention (NPI) strategies, such as masking and social distancing, to slow the spread of a viral epidemic. We formulate the problem of jointly minimizing the infection…

Systems and Control · Electrical Eng. & Systems 2024-12-02 Shiyu Cheng , Luyao Niu , Bhaskar Ramasubramanian , Andrew Clark , Radha Poovendran

Decision-making in complex, continuous multi-task environments is often hindered by the difficulty of obtaining accurate models for planning and the inefficiency of learning purely from trial and error. While precise environment dynamics…

Machine Learning · Computer Science 2025-03-20 Jeff Jewett , Sandhya Saisubramanian

We propose a new approach for solving planning problems with a hierarchical structure, fusing reinforcement learning and MPC planning. Our formulation tightly and elegantly couples the two planning paradigms. It leverages reinforcement…

Machine Learning · Computer Science 2026-04-17 Toshiaki Hori , Jonathan DeCastro , Deepak Gopinath , Avinash Balachandran , Guy Rosman
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