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Large language models (LLMs) show significant potential in healthcare, prompting numerous benchmarks to evaluate their capabilities. However, concerns persist regarding the reliability of these benchmarks, which often lack clinical…

Computation and Language · Computer Science 2026-04-30 Wenting Chen , Guo Yu , Yiu-Fai Cheung , Meidan Ding , Jie Liu , Zizhan Ma , Wenxuan Wang , Linlin Shen

This study reviewed the use of Large Language Models (LLMs) in healthcare, focusing on their training corpora, customization techniques, and evaluation metrics. A systematic search of studies from 2021 to 2024 identified 61 articles. Four…

Computation and Language · Computer Science 2025-02-18 Shuqi Yang , Mingrui Jing , Shuai Wang , Jiaxin Kou , Manfei Shi , Weijie Xing , Yan Hu , Zheng Zhu

The use of Large Language Models (LLMs) to support patients in addressing medical questions is becoming increasingly prevalent. However, most of the measures currently used to evaluate the performance of these models in this context only…

Human-Computer Interaction · Computer Science 2026-04-22 Abu Noman Md Sakib , Md. Main Oddin Chisty , Zijie Zhang

There is a lack of benchmarks for evaluating large language models (LLMs) in long-form medical question answering (QA). Most existing medical QA evaluation benchmarks focus on automatic metrics and multiple-choice questions. While valuable,…

Computation and Language · Computer Science 2024-11-21 Pedram Hosseini , Jessica M. Sin , Bing Ren , Bryceton G. Thomas , Elnaz Nouri , Ali Farahanchi , Saeed Hassanpour

Alignment techniques have become central to ensuring that Large Language Models (LLMs) generate outputs consistent with human values. However, existing alignment paradigms often model an averaged or monolithic preference, failing to account…

Computation and Language · Computer Science 2025-06-03 Anudeex Shetty , Amin Beheshti , Mark Dras , Usman Naseem

Publicly accessible benchmarks that allow for assessing and comparing model performances are important drivers of progress in artificial intelligence (AI). While recent advances in AI capabilities hold the potential to transform medical…

Artificial Intelligence · Computer Science 2022-12-26 Kathrin Blagec , Jakob Kraiger , Wolfgang Frühwirt , Matthias Samwald

Large language models (LLMs) are increasingly used to provide health advice, yet evidence on how their accuracy varies across languages, topics and information sources remains limited. We assess how linguistic and contextual factors affect…

General Economics · Economics 2026-02-25 Prashant Garg , Thiemo Fetzer

While Large Language Models (LLMs) achieve superhuman performance on standardized medical licensing exams, these static benchmarks have become saturated and increasingly disconnected from the functional requirements of clinical workflows.…

Background: Recent advancements in large language models (LLMs) offer potential benefits in healthcare, particularly in processing extensive patient records. However, existing benchmarks do not fully assess LLMs' capability in handling…

Recent advances in Retrieval-Augmented Generation (RAG) have enabled large language models (LLMs) to ground outputs in clinical evidence. However, connecting LLMs with external databases introduces the risk of contextual leakage: a subtle…

Computation and Language · Computer Science 2026-03-17 Shaowei Guan , Yu Zhai , Hin Chi Kwok , Jiawei Du , Xinyu Feng , Jing Li , Harry Qin , Vivian Hui

Medical large language models (LLMs) research often makes bold claims, from encoding clinical knowledge to reasoning like a physician. These claims are usually backed by evaluation on competitive benchmarks; a tradition inherited from…

Computation and Language · Computer Science 2025-03-17 Ahmed Alaa , Thomas Hartvigsen , Niloufar Golchini , Shiladitya Dutta , Frances Dean , Inioluwa Deborah Raji , Travis Zack

AI models are increasingly deployed in live clinical environments where they must perform reliably across complex, high-stakes workflows that standard training and validation datasets were never designed to capture. Evaluating these systems…

Artificial Intelligence · Computer Science 2026-05-12 Prasanna Desikan , Harshit Rajgarhia , Shivali Dalmia , Ananya Mantravadi

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

Medical large language models (LLMs) achieve impressive performance on standardized benchmarks, yet these evaluations fail to capture the complexity of real clinical encounters where patients exhibit memory gaps, limited health literacy,…

Artificial Intelligence · Computer Science 2026-04-14 Sina Mansouri , Mohit Marvania , Vibhavari Ashok Shihorkar , Han Ngoc Tran , Kazhal Shafiei , Mehrdad Fazli , Yikuan Li , Ziwei Zhu

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu

Current Large Language Models (LLMs) benchmarks are often based on open-ended or close-ended QA evaluations, avoiding the requirement of human labor. Close-ended measurements evaluate the factuality of responses but lack expressiveness.…

The application of large language models (LLMs) in healthcare holds significant promise for enhancing clinical decision-making, medical research, and patient care. However, their integration into real-world clinical settings raises critical…

Computers and Society · Computer Science 2025-09-18 Manar Aljohani , Jun Hou , Sindhura Kommu , Xuan Wang

As large language models (LLMs) become primary sources of health information for millions, their accuracy in women's health remains critically unexamined. We introduce the Women's Health Benchmark (WHB), the first benchmark evaluating LLM…

Large Language Models (LLMs) are advancing rapidly, yet the benchmarks used to measure this progress are becoming increasingly unreliable. Score inflation and selective reporting have eroded the authority of standard benchmarks, leaving the…

Artificial Intelligence · Computer Science 2026-02-13 Longyuan Zhu , Hairan Hua , Linlin Miao , Bing Zhao

Background: The rapid integration of foundation models into clinical practice and public health necessitates a rigorous evaluation of their true clinical reasoning capabilities beyond narrow examination success. Current benchmarks,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Dingyu Wang , Zimu Yuan , Jiajun Liu , Shanggui Liu , Nan Zhou , Tianxing Xu , Di Huang , Dong Jiang
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