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In this paper, for the first time, we propose an evaluation method for deep learning models that assesses the performance of a model not only in an unseen test scenario, but also in extreme cases of noise, outliers and ambiguous input data.…

Computer Vision and Pattern Recognition · Computer Science 2018-04-03 Magdalini Paschali , Sailesh Conjeti , Fernando Navarro , Nassir Navab

Although deep learning models in medical imaging often achieve excellent classification performance, they can rely on shortcut learning, exploiting spurious correlations or confounding factors that are not causally related to the target…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Sarah Müller , Philipp Berens

The restricted polynomially-tilted pairwise interaction (RPPI) distribution gives a flexible model for compositional data. It is particularly well-suited to situations where some of the marginal distributions of the components of a…

Methodology · Statistics 2023-05-15 Janice L. Scealy , Kassel L. Hingee , John T. Kent , Andrew T. A. Wood

In high-dimensional multivariate regression problems, enforcing low rank in the coefficient matrix offers effective dimension reduction, which greatly facilitates parameter estimation and model interpretation. However, commonly-used…

Statistics Theory · Mathematics 2017-07-18 Yiyuan She , Kun Chen

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Machine Learning · Computer Science 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Multi-site structural MRI is increasingly used in neuroimaging studies to diversify subject cohorts. However, combining MR images acquired from various sites/centers may introduce site-related non-biological variations. Retrospective image…

Image and Video Processing · Electrical Eng. & Systems 2024-08-20 Mengqi Wu , Minhui Yu , Shuaiming Jing , Pew-Thian Yap , Zhengwu Zhang , Mingxia Liu

The proper handling of out-of-distribution (OOD) samples in deep classifiers is a critical concern for ensuring the suitability of deep neural networks in safety-critical systems. Existing approaches developed for robust OOD detection in…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Nasrin Alipour , Seyyed Ali SeyyedSalehi

Purpose: Combining multi-site diffusion MRI (dMRI) data is hindered by inter-scanner variability, which confounds subsequent analysis. Previous harmonization methods require large, matched or traveling human subjects from multiple sites,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Hwihun Jeong , Qiang Liu , Kathryn E. Keenan , Elisabeth A. Wilde , Walter Schneider , Sudhir Pathak , Anthony Zuccolotto , Lauren J. O'Donnell , Lipeng Ning , Yogesh Rathi

Two important considerations in clinical research studies are proper evaluations of internal and external validity. While randomized clinical trials can overcome several threats to internal validity, they may be prone to poor external…

Methodology · Statistics 2022-07-19 Kevin P. Josey , Fan Yang , Debashis Ghosh , Sridharan Raghavan

Data analysis based on information from several sources is common in economic and biomedical studies. This setting is often referred to as the data fusion problem, which differs from traditional missing data problems since no complete data…

Methodology · Statistics 2022-04-07 Wei Li , Shanshan Luo , Wangli Xu

This paper evaluates six strategies for mitigating imbalanced data: oversampling, undersampling, ensemble methods, specialized algorithms, class weight adjustments, and a no-mitigation approach referred to as the baseline. These strategies…

Machine Learning · Computer Science 2023-11-13 Jacques Wainer

Many neurological diseases are characterized by gradual deterioration of brain structure and function. Large longitudinal MRI datasets have revealed such deterioration, in part, by applying machine and deep learning to predict diagnosis. A…

Image and Video Processing · Electrical Eng. & Systems 2021-05-27 Jiahong Ouyang , Qingyu Zhao , Edith V Sullivan , Adolf Pfefferbaum , Susan F. Tapert , Ehsan Adeli , Kilian M Pohl

Applying machine learning to real-world medical data, e.g. from hospital archives, has the potential to revolutionize disease detection in brain images. However, detecting pathology in such heterogeneous cohorts is a difficult challenge.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Ana Lawry Aguila , Ayodeji Ijishakin , Juan Eugenio Iglesias , Tomomi Takenaga , Yukihiro Nomura , Takeharu Yoshikawa , Osamu Abe , Shouhei Hanaoka

Integrating the outputs of multiple classifiers via combiners or meta-learners has led to substantial improvements in several difficult pattern recognition problems. In the typical setting investigated till now, each classifier is trained…

Machine Learning · Computer Science 2007-05-23 Kagan Tumer , Joydeep Ghosh

It is of importance to develop statistical techniques to analyze high-dimensional data in the presence of both complex dependence and possible outliers in real-world applications such as imaging data analyses. We propose a new robust…

Methodology · Statistics 2021-10-01 Bingyuan Liu , Qi Zhang , Lingzhou Xue , Peter X. K. Song , Jian Kang

In MRI, images of the same contrast (e.g., T$_1$) from the same subject can exhibit noticeable differences when acquired using different hardware, sequences, or scan parameters. These differences in images create a domain gap that needs to…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Hwihun Jeong , Heejoon Byun , Dong Un Kang , Jongho Lee

Outlier-robust estimation is a fundamental problem and has been extensively investigated by statisticians and practitioners. The last few years have seen a convergence across research fields towards "algorithmic robust statistics", which…

Machine Learning · Statistics 2022-12-19 Luca Carlone

Doubly robust estimators are widely used for estimating average treatment effects and other linear summaries of regression functions. While consistency requires only one of two nuisance functions to be estimated consistently, asymptotic…

Methodology · Statistics 2025-07-01 Lars van der Laan , Alex Luedtke , Marco Carone

In practice, network applications have to deal with failing nodes, malicious attacks, or, somehow, nodes facing highly corrupted data --- generally classified as outliers. This calls for robust, uncomplicated, and efficient methods. We…

Optimization and Control · Mathematics 2014-10-10 Cláudia Soares , João Gomes

Spatial perception is the backbone of many robotics applications, and spans a broad range of research problems, including localization and mapping, point cloud alignment, and relative pose estimation from camera images. Robust spatial…

Machine Learning · Statistics 2019-07-31 Vasileios Tzoumas , Pasquale Antonante , Luca Carlone
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