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Drug discovery is lengthy and expensive, with traditional computer-aided design facing limits. This paper examines integrating quantum computing across the drug development cycle to accelerate and enhance workflows and rigorous…

High-performance computing (HPC) has evolved over decades through multiple architectural transitions, from vector supercomputers to massively parallel CPU clusters and GPU-accelerated systems, continuously expanding the frontier of…

Quantum Physics · Physics 2026-04-23 Suman Raj , Siva Sai , Yogesh Simmhan , Kyle Chard , Rajkumar Buyya

Quantum computing, with its superior computational capabilities compared to classical approaches, holds the potential to revolutionize numerous scientific domains, including pharmaceuticals. However, the application of quantum computing for…

The connection and eventual integration of High-Performance Computing (HPC) with Quantum Computing (QC) represents a transformative advancement in computational technology, promising significant enhancements in solving complex, previously…

The field of drug discovery hinges on the accurate prediction of binding affinity between prospective drug molecules and target proteins, especially when such proteins directly influence disease progression. However, estimating binding…

Quantum Computing (QC) offers outstanding potential for molecular characterization and drug discovery, particularly in solving complex properties like the Ground State Energy (GSE) of biomolecules. However, QC faces challenges due to…

Chemical Physics · Physics 2024-12-17 Laia Coronas Sala , Parfait Atchade-Adelemou

We explored the possible benefits of integrating quantum simulators in a "hybrid" quantum machine learning (QML) workflow that uses both classical and quantum computations in a high-performance computing (HPC) environment. Here, we used two…

Emerging Technologies · Computer Science 2024-07-11 Samuel T. Bieberich , Michael A. Sandoval

Quantum Machine Learning represents a paradigm shift at the intersection of Quantum Computing and Machine Learning, leveraging quantum phenomena such as superposition, entanglement, and quantum parallelism to address the limitations of…

Quantum Physics · Physics 2025-01-17 Sahil Tomar , Rajeshwar Tripathi , Sandeep Kumar

Achieving high-performance computation on quantum systems presents a formidable challenge that necessitates bridging the capabilities between quantum hardware and classical computing resources. This study introduces an innovative…

Quantum Physics · Physics 2024-03-19 Kuan-Cheng Chen , Xiaoren Li , Xiaotian Xu , Yun-Yuan Wang , Chen-Yu Liu

Scientific applications are starting to explore the viability of quantum computing. This exploration typically begins with quantum simulations that can run on existing classical platforms, albeit without the performance advantages of real…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-08-16 Amir Shehata , Thomas Naughton , In-Saeng Suh

The prospects of quantum computing have driven efforts to realize fully functional quantum processing units (QPUs). Recent success in developing proof-of-principle QPUs has prompted the question of how to integrate these emerging processors…

Emerging Technologies · Computer Science 2015-12-10 Keith A. Britt , Travis S. Humble

High-Performance Computing (HPC) systems are the most powerful tools that we currently have to solve complex scientific simulations. Quantum computing (QC) has the potential to enhance HPC systems by accelerating the execution of specific…

This paper presents a comprehensive software stack architecture for integrating quantum computing (QC) capabilities with High-Performance Computing (HPC) environments. While quantum computers show promise as specialized accelerators for…

The digitization of healthcare presents numerous challenges, including the complexity of biological systems, vast data generation, and the need for personalized treatment plans. Traditional computational methods often fall short, leading to…

Emerging Technologies · Computer Science 2025-07-25 Markus Bertl , Alan Mott , Salvatore Sinno , Bhavika Bhalgamiya

The next generation of particle physics experiments will face a new era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing this data for…

Instrumentation and Detectors · Physics 2026-03-12 Julia Gonski , Jenni Ott , Shiva Abbaszadeh , Sagar Addepalli , Matteo Cremonesi , Jennet Dickinson , Giuseppe Di Guglielmo , Erdem Yigit Ertorer , Lindsey Gray , Ryan Herbst , Christian Herwig , Tae Min Hong , Benedikt Maier , Maryam Bayat Makou , David Miller , Mark S. Neubauer , Cristián Peña , Dylan Rankin , Seon-Hee , Seo , Giordon Stark , Alexander Tapper , Audrey Corbeil Therrien , Ioannis Xiotidis , Keisuke Yoshihara , G Abarajithan , Sagar Addepalli , Nural Akchurin , Carlos Argüelles , Saptaparna Bhattacharya , Lorenzo Borella , Christian Boutan , Tom Braine , James Brau , Martin Breidenbach , Antonio Chahine , Talal Ahmed Chowdhury , Yuan-Tang Chou , Seokju Chung , Alberto Coppi , Mariarosaria D'Alfonso , Abhilasha Dave , Chance Desmet , Angela Di Fulvio , Karri DiPetrillo , Javier Duarte , Auralee Edelen , Jan Eysermans , Yongbin Feng , Emmett Forrestel , Dolores Garcia , Loredana Gastaldo , Julián García Pardiñas , Lino Gerlach , Loukas Gouskos , Katya Govorkova , Carl Grace , Christopher Grant , Philip Harris , Ciaran Hasnip , Timon Heim , Abraham Holtermann , Tae Min Hong , Gian Michele Innocenti , Koji Ishidoshiro , Miaochen Jin , Jyothisraj Johnson , Stephen Jones , Andreas Jung , Georgia Karagiorgi , Ryan Kastner , Nicholas Kamp , Doojin Kim , Kyoungchul Kong , Katie Kudela , Jelena Lalic , Bo-Cheng Lai , Yun-Tsung Lai , Tommy Lam , Jeffrey Lazar , Aobo Li , Zepeng Li , Haoyun Liu , Vladimir Lončar , Luca Macchiarulo , Christopher Madrid , Benedikt Maier , Zhenghua Ma , Prashansa Mukim , Mark S. Neubauer , Victoria Nguyen , Sungbin Oh , Isobel Ojalvo , Hideyoshi Ozaki , Simone Pagan Griso , Myeonghun Park , Christoph Paus , Santosh Parajuli , Benjamin Parpillon , Sara Pozzi , Ema Puljak , Benjamin Ramhorst , Amy Roberts , Larry Ruckman , Kate Scholberg , Sebastian Schmitt , Noah Singer , Eluned Anne Smith , Alexandre Sousa , Michael Spannowsky , Sioni Summers , Yanwen Sun , Daniel Tapia Takaki , Antonino Tumeo , Caterina Vernieri , Belina von Krosigk , Yash Vora , Linyan Wan , Michael H. L. S. Wang , Amanda Weinstein , Andy White , Simon Williams , Felix Yu

The nexus of quantum computing and machine learning - quantum machine learning - offers the potential for significant advancements in chemistry. This review specifically explores the potential of quantum neural networks on gate-based…

In the expanding field of Quantum Computing (QC), efficient and seamless integration of QC and high performance computing (HPC) elements (e.g., quantum hardware, classical hardware, and software infrastructure on both sides) plays a crucial…

Quantum Physics · Physics 2023-09-08 Philipp Seitz , Amr Elsharkawy , Xiao-Ting Michelle To , Martin Schulz

A significant challenge in quantum computing (QC) is developing learning models that truly align with quantum principles, as many current approaches are complex adaptations of classical frameworks. In this work, we introduce Quantum…

This PhD thesis explores the potential of quantum computing to address computational challenges in high-energy physics (HEP). As the Standard Model (SM) leaves key questions unanswered and no signs of new physics have emerged since the…

Quantum Physics · Physics 2025-12-02 Jorge J. Martínez de Lejarza

For the first time in history, we are seeing a branching point in computing paradigms with the emergence of quantum processing units (QPUs). Extracting the full potential of computation and realizing quantum algorithms with a…

Quantum Physics · Physics 2022-11-29 Sergey Bravyi , Oliver Dial , Jay M. Gambetta , Dario Gil , Zaira Nazario
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