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Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-level visualization of biomolecular assemblies. However, the exponential growth in cryo-EM data throughput and complexity, coupled with diverse…

Quantitative Methods · Quantitative Biology 2026-02-25 Weining Fu , Kai Shu , Kui Xu , Qiangfeng Cliff Zhang

Comprehensive and unambiguous identification of small molecules in complex samples will revolutionize our understanding of the role of metabolites in biological systems. Existing and emerging technologies have enabled measurement of…

Biomolecules · Quantitative Biology 2019-05-22 Sean M. Colby , Jamie R. Nuñez , Nathan O. Hodas , Courtney D. Corley , Ryan R. Renslow

Microstructure is key to controlling and understanding the properties of metallic materials, but traditional approaches to describing microstructure capture only a small number of features. To enable data-centric approaches to materials…

We propose a variational autoencoder (VAE)-based model for building forward and inverse structure-property linkages, a problem of paramount importance in computational materials science. Our model systematically combines VAE with…

Machine Learning · Computer Science 2024-02-29 Avadhut Sardeshmukh , Sreedhar Reddy , BP Gautham , Pushpak Bhattacharyya

Determining the dimensions of nanostructures is critical to ensuring the maximum performance of many geometry-sensitive nanoscale functional devices. However, accurate metrology at the nanoscale is difficult using optics-based methods due…

Applied Physics · Physics 2019-08-21 Jinlong Zhu , Yanan Liu , Sanyogita Purandare , Jian-Ming Jin , Shiyuan Liu , Lynford L. Goddard

Deep neural networks face several challenges in hyperspectral image classification, including complex and sparse ground object distributions, small clustered structures, and elongated multi-branch features that often lead to missing…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Guandong Li , Mengxia Ye

Deep learning (DL) is one of the fastest growing topics in materials data science, with rapidly emerging applications spanning atomistic, image-based, spectral, and textual data modalities. DL allows analysis of unstructured data and…

Many physics-informed machine learning methods for PDE-based problems rely on Gaussian processes (GPs) or neural networks (NNs). However, both face limitations when data are scarce and the dimensionality is high. Although GPs are known for…

Machine Learning · Computer Science 2025-01-31 Weihao Yan , Christoph Brune , Mengwu Guo

Accelerating the discovery of mechanical properties in combinatorial materials requires autonomous experimentation that accounts for both instrument behavior and experimental cost. Here, an automated nanoindentation (AE-NI) framework is…

Materials Science · Physics 2025-11-24 Vivek Chawla , Stephen Puplampu , Haochen Zhu , Philip D. Rack , Dayakar Penumadu , Sergei Kalinin

Spectral Embedding (SE) has often been used to map data points from non-linear manifolds to linear subspaces for the purpose of classification and clustering. Despite significant advantages, the subspace structure of data in the original…

Computer Vision and Pattern Recognition · Computer Science 2023-05-16 Hira Yaseen , Arif Mahmood

Materials informatics (MI), emerging from the integration of materials science and data science, is expected to significantly accelerate material development and discovery. The data used in MI are derived from both computational and…

Materials Science · Physics 2025-04-09 Yusuke Hashimoto , Xue Jia , Hao Li , Takaaki Tomai

Dynamics of protein self-assembly on the inorganic surface and the resultant geometric patterns are visualized using high-speed atomic force microscopy. The time dynamics of the classical macroscopic descriptors such as 2D Fast Fourier…

In the present work, a generative deep learning framework combining a Co-optimized Variational Autoencoder (Co-VAE) architecture with quantitative structure-property relationship (QSPR) techniques is developed to enable accelerated inverse…

Machine Learning · Computer Science 2025-10-15 Kiran K. Yalamanchi , Pinaki Pal , Balaji Mohan , Abdullah S. AlRamadan , Jihad A. Badra , Yuanjiang Pei

Near-field optical microscopy can be used as a viable route to understand the nanoscale material properties below the diffraction limit. On the other hand, atomically thin two-dimensional (2D) transition metal dichalcogenides (TMDs) are the…

Recent advances in scanning transmission electron and scanning tunneling microscopies allow researchers to measure materials structural and electronic properties, such as atomic displacements and charge density modulations, at an Angstrom…

Hierarchical transformers have achieved significant success in medical image segmentation due to their large receptive field and capabilities of effectively leveraging global long-range contextual information. Convolutional neural networks…

Image and Video Processing · Electrical Eng. & Systems 2024-10-18 Jin Yang , Peijie Qiu , Yichi Zhang , Daniel S. Marcus , Aristeidis Sotiras

Hyperspectral imagery is rich in spatial and spectral information. Using 3D-CNN can simultaneously acquire features of spatial and spectral dimensions to facilitate classification of features, but hyperspectral image information spectral…

Image and Video Processing · Electrical Eng. & Systems 2022-02-15 Guandong Li , Chunju Zhang

High-throughput biological imaging is often constrained by a trade-off between acquisition speed and image quality. Fast imaging modalities, such as wide-field fluorescence microscopy, enable large-scale data acquisition but suffer from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-20 Dominik Panek , Carina Rząca , Maksymilian Szczypior , Joanna Sorysz , Krzysztof Misztal , Zbigniew Baster , Zenon Rajfur

Leveraging on the underlying low-dimensional structure of data, low-rank and sparse modeling approaches have achieved great success in a wide range of applications. However, in many applications the data can display structures beyond simply…

Machine Learning · Computer Science 2019-12-04 Zhao Kang , Xiao Lu , Yiwei Lu , Chong Peng , Zenglin Xu

In an effort to explore high-throughput processing of microscopic image data, a method based on deep convolutional neural network is proposed. The state-of-the-art computer vision algorithm, Faster R-CNN, was trained for the detection of…

Disordered Systems and Neural Networks · Physics 2021-03-09 Ze-Bin Wu