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The trade-off between accuracy and interpretability has long been a challenge in machine learning (ML). This tension is particularly significant for emerging interpretable-by-design methods, which aim to redesign ML algorithms for…

Machine Learning · Computer Science 2025-05-28 Geyu Liang , Senne Michielssen , Salar Fattahi

In many scientific domains, including experimentation, researchers rely on measurements of proxy outcomes to achieve faster and more frequent reads, especially when the primary outcome of interest is challenging to measure directly. While…

Methodology · Statistics 2026-05-08 Steven Wilkins-Reeves , Alexandra N. M. Darmon , Deeksha Sinha

Prediction accuracy and model explainability are the two most important objectives when developing machine learning algorithms to solve real-world problems. The neural networks are known to possess good prediction performance, but lack of…

Machine Learning · Statistics 2019-09-04 Zebin Yang , Aijun Zhang , Agus Sudjianto

When quantitative models are used to support decision-making on complex and important topics, understanding a model's ``reasoning'' can increase trust in its predictions, expose hidden biases, or reduce vulnerability to adversarial attacks.…

Machine Learning · Computer Science 2019-07-09 Dimitris Bertsimas , Arthur Delarue , Patrick Jaillet , Sebastien Martin

Algorithmic approaches to interpreting machine learning models have proliferated in recent years. We carry out human subject tests that are the first of their kind to isolate the effect of algorithmic explanations on a key aspect of model…

Computation and Language · Computer Science 2020-05-06 Peter Hase , Mohit Bansal

Synthetic Lethal (SL) relationships, though rare among the vast array of gene combinations, hold substantial promise for targeted cancer therapy. Despite advancements in AI model accuracy, there is still a significant need among domain…

Human-Computer Interaction · Computer Science 2024-07-23 Haoran Jiang , Shaohan Shi , Shuhao Zhang , Jie Zheng , Quan Li

Foundation model reliability assessment typically requires thousands of evaluation examples, making it computationally expensive and time-consuming for real-world deployment. We introduce microprobe, a novel approach that achieves…

Artificial Intelligence · Computer Science 2025-12-25 Aayam Bansal , Ishaan Gangwani

The need for reliable model explanations is prominent for many machine learning applications, particularly for tabular and time-series data as their use cases often involve high-stakes decision making. Towards this goal, we introduce a…

Machine Learning · Computer Science 2023-05-29 Aya Abdelsalam Ismail , Sercan Ö. Arik , Jinsung Yoon , Ankur Taly , Soheil Feizi , Tomas Pfister

We introduce Leap+Verify, a framework that applies speculative execution -- predicting future model weights and validating predictions before acceptance -- to accelerate neural network training. Inspired by speculative decoding in language…

Machine Learning · Computer Science 2026-02-24 Jeremy McEntire

Large language models (LLMs) are increasingly used as generators in iterative neural architecture search (NAS), yet no formal convergence theory exists for this class of algorithms. We model iterative LLM-NAS as a parametric Cross-Entropy…

Machine Learning · Computer Science 2026-05-29 Santosh Premi Adhikari , Radu Timofte , Dmitry Ignatov

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

Reliable pattern recognition systems should exhibit consistent behavior across similar inputs, and their explanations should remain stable. However, most Explainable AI evaluations remain instance centric and do not explicitly quantify…

Artificial Intelligence · Computer Science 2026-04-07 Abu Noman Md Sakib , Zhensen Wang , Merjulah Roby , Zijie Zhang

High-stakes applications require AI-generated models to be interpretable. Current algorithms for the synthesis of potentially interpretable models rely on objectives or regularization terms that represent interpretability only coarsely…

Machine Learning · Computer Science 2021-04-28 Marco Virgolin , Andrea De Lorenzo , Francesca Randone , Eric Medvet , Mattias Wahde

Sequential algorithms for the Stable Matching Problem are often too slow in the context of some large scale applications like switch scheduling. Parallel architectures can offer a notable decrease in runtime complexity. We propose a stable…

Data Structures and Algorithms · Computer Science 2024-08-27 Scott Wynn , Alec Kyritsis , Stephora Alberi , Enyue Lu

Recent deep learning methods for fMRI-based diagnosis have achieved promising accuracy by modeling functional connectivity networks. However, standard approaches often struggle with noisy interactions, and conventional post-hoc attribution…

Machine Learning · Computer Science 2026-02-25 Kunyu Zhang , Yanwu Yang , Jing Zhang , Xiangjie Shi , Shujian Yu

One of the major challenges in machine learning nowadays is to provide predictions with not only high accuracy but also user-friendly explanations. Although in recent years we have witnessed increasingly popular use of deep neural networks…

Machine Learning · Computer Science 2019-07-24 Yao Ming , Panpan Xu , Huamin Qu , Liu Ren

Local Interpretable Model-Agnostic Explanations (LIME) is a popular technique used to increase the interpretability and explainability of black box Machine Learning (ML) algorithms. LIME typically generates an explanation for a single…

Machine Learning · Computer Science 2019-06-26 Muhammad Rehman Zafar , Naimul Mefraz Khan

Prognostic Health Management (PHM) systems monitor and predict equipment health. A key task is Remaining Useful Life (RUL) estimation, which predicts how long a component, such as a rolling element bearing, will operate before failure. Many…

Machine Learning · Computer Science 2025-10-22 Waleed Razzaq , Yun-Bo Zhao

Explainable Artificial Intelligence (xAI) has the potential to enhance the transparency and trust of AI-based systems. Although accurate predictions can be made using Deep Neural Networks (DNNs), the process used to arrive at such…

Computer Vision and Pattern Recognition · Computer Science 2024-08-09 Bhushan Atote , Victor Sanchez

We present a linear stability analysis of physics-informed random projection neural networks (PI-RPNNs), for the numerical solution of {the initial value problem (IVP)} of (stiff) ODEs. We begin by proving that PI-RPNNs are uniform…

Numerical Analysis · Mathematics 2025-07-30 Gianluca Fabiani , Erik Bollt , Constantinos Siettos , Athanasios N. Yannacopoulos