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Learning compact and interpretable representations of data is a critical challenge in scientific image analysis. Here, we introduce Affinity-VAE, a generative model that enables us to impose our scientific intuition about the similarity of…

Scanning transmission electron microscopy (STEM) is an extremely versatile method for studying materials on the atomic scale. Many STEM experiments are supported or validated with electron scattering simulations. However, using the…

Variational Autoencoder is a scalable method for learning latent variable models of complex data. It employs a clear objective that can be easily optimized. However, it does not explicitly measure the quality of learned representations. We…

Machine Learning · Computer Science 2020-05-29 Andriy Serdega , Dae-Shik Kim

Learning rich data representations from unlabeled data is a key challenge towards applying deep learning algorithms in downstream tasks. Several variants of variational autoencoders (VAEs) have been proposed to learn compact data…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Pan Xiao , Peijie Qiu , Sungmin Ha , Abdalla Bani , Shuang Zhou , Aristeidis Sotiras

Purpose Surgical simulations play an increasingly important role in surgeon education and developing algorithms that enable robots to perform surgical subtasks. To model anatomy, Finite Element Method (FEM) simulations have been held as the…

Robotics · Computer Science 2020-03-27 Jie Ying Wu , Peter Kazanzides , Mathias Unberath

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

Methodology · Statistics 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon

Electron microscopy has shown to be a very powerful tool to map the chemical nature of samples at various scales down to atomic resolution. However, many samples can not be analyzed with an acceptable signal-to-noise ratio because of the…

Image and Video Processing · Electrical Eng. & Systems 2018-02-28 Étienne Monier , Thomas Oberlin , Nathalie Brun , Marcel Tencé , Marta de Frutos , Nicolas Dobigeon

All coronagraphic instruments for exoplanet high-contrast imaging need wavefront correction systems to reject optical aberrations and create sufficiently dark holes. Since the most efficient wavefront correction algorithms (controllers and…

Instrumentation and Methods for Astrophysics · Physics 2018-10-09 He Sun , N. Jeremy Kasdin , Robert Vanderbei

We propose to utilize a variational autoencoder (VAE) for data-driven channel estimation. The underlying true and unknown channel distribution is modeled by the VAE as a conditional Gaussian distribution in a novel way, parameterized by the…

Signal Processing · Electrical Eng. & Systems 2023-04-07 Michael Baur , Benedikt Fesl , Michael Koller , Wolfgang Utschick

A new approach for blind channel equalization and decoding, variational inference, and variational autoencoders (VAEs) in particular, is introduced. We first consider the reconstruction of uncoded data symbols transmitted over a noisy…

Machine Learning · Computer Science 2020-04-14 Avi Caciularu , David Burshtein

We investigate the potential of adaptive blind equalizers based on variational inference for carrier recovery in optical communications. These equalizers are based on a low-complexity approximation of maximum likelihood channel estimation.…

Signal Processing · Electrical Eng. & Systems 2022-09-16 Vincent Lauinger , Fred Buchali , Laurent Schmalen

Buildings rarely perform as designed/simulated and and there are numerous tangible benefits if this gap is reconciled. A new scientific yet pragmatic methodology - called Enhanced Parameter Estimation (EPE) - is proposed that allows…

Systems and Control · Electrical Eng. & Systems 2021-03-15 Kris Subbarao , Srijan Didwania , T. Agami Reddy , Marlin Addison

A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Shay Kreymer , Amit Singer , Tamir Bendory

Although Vision Transformers (ViTs) have recently advanced computer vision tasks significantly, an important real-world problem was overlooked: adapting to variable input resolutions. Typically, images are resized to a fixed resolution,…

Computer Vision and Pattern Recognition · Computer Science 2024-05-29 Wenzhuo Liu , Fei Zhu , Shijie Ma , Cheng-Lin Liu

Electromyogram (EMG)-based motion classification using machine learning has been widely employed in applications such as prosthesis control. While previous studies have explored generating synthetic patterns of combined motions to reduce…

Signal Processing · Electrical Eng. & Systems 2025-11-13 Itsuki Yazawa , Akira Furui

Variational auto-encoders (VAEs) provide an attractive solution to image generation problem. However, they tend to produce blurred and over-smoothed images due to their dependence on pixel-wise reconstruction loss. This paper introduces a…

Computer Vision and Pattern Recognition · Computer Science 2018-04-30 Salman H. Khan , Munawar Hayat , Nick Barnes

Photon-counting computed tomography has demonstrated significant advancements in recent years; however, micro photon-counting CT (Micro-PCCT) systems are still limited by pixel-wise detector response nonuniformity, which degrades…

Medical Physics · Physics 2026-03-31 Enze Zhou , Wenjian Li , Wenting Xu , Yuwei Lu , Shangbin Chen , Shaoyang Wang , Gang Zheng , Tianwu Xie , Qian Liu

LLMs increasingly require surgical model editing to enhance domain-specific capabilities without incurring the computational cost or catastrophic forgetting associated with full fine-tuning. Sparse Autoencoders (SAEs) have emerged as a…

Machine Learning · Computer Science 2026-05-28 Li Lei , Madalina Ciobanu , Qingqing Mao , Ritankar Das

The deployment of machine learning classifiers in high-stakes domains requires well-calibrated confidence scores for model predictions. In this paper we introduce the notion of variable-based calibration to characterize calibration…

Machine Learning · Computer Science 2023-04-07 Markelle Kelly , Padhraic Smyth

Cryo-electron microscopy (Cryo-EM) enables high-resolution imaging of biomolecules, but structural heterogeneity remains a major challenge in 3D reconstruction. Traditional methods assume a discrete set of conformations, limiting their…

Machine Learning · Statistics 2025-09-09 Diego Sanchez Espinosa , Erik H Thiede , Yunan Yang
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