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While multimodal data integrating diverse imaging and clinical tabular records is crucial for accurate medical diagnosis, the arbitrary absence of specific modalities is prevalent in clinical practice, severely degrading the performance of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Tianling Liu , Lequan Yu , Tong Han , Liang Wan

Multimodality has recently gained attention in the medical domain, where imaging or video modalities may be integrated with biomedical signals or health records. Yet, two challenges remain: balancing the contributions of modalities,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Julie Mordacq , Leo Milecki , Maria Vakalopoulou , Steve Oudot , Vicky Kalogeiton

Visual question answering (VQA) is crucial for promoting surgical education. In practice, the needs of trainees are constantly evolving, such as learning more surgical types, adapting to different robots, and learning new surgical…

Information Retrieval · Computer Science 2024-10-24 Yuyang Du , Kexin Chen , Yue Zhan , Chang Han Low , Tao You , Mobarakol Islam , Ziyu Guo , Yueming Jin , Guangyong Chen , Pheng-Ann Heng

A key challenge in learning from multimodal biological data is missing modalities, where data from one or more modalities are absent for some patients. Existing approaches either exclude patients with missing modalities, impute missing…

Machine Learning · Computer Science 2026-05-19 Sina Tabakhi , Chen , Chen , Haiping Lu

The vision-language modeling capability of multi-modal large language models has attracted wide attention from the community. However, in medical domain, radiology report generation using vision-language models still faces significant…

Computer Vision and Pattern Recognition · Computer Science 2024-08-23 Yuhao Wang , Chao Hao , Yawen Cui , Xinqi Su , Weicheng Xie , Tao Tan , Zitong Yu

AI tools in pathology have improved screening throughput, standardized quantification, and revealed prognostic patterns that inform treatment. However, adoption remains limited because most systems still lack the human-readable reasoning…

Artificial Intelligence · Computer Science 2025-11-18 Yunqi Hong , Johnson Kao , Liam Edwards , Nein-Tzu Liu , Chung-Yen Huang , Alex Oliveira-Kowaleski , Cho-Jui Hsieh , Neil Y. C. Lin

This paper introduces an innovative multi-modal fusion deep learning approach to overcome the drawbacks of traditional single-modal recognition techniques. These drawbacks include incomplete information and limited diagnostic accuracy.…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Xiaoyi Liu , Hongjie Qiu , Muqing Li , Zhou Yu , Yutian Yang , Yafeng Yan

Early recurrence (ER) prediction after curative-intent resection remains a critical challenge in the clinical management of hepatocellular carcinoma (HCC). Although contrast-enhanced computed tomography (CT) with full multi-phase…

Quantitative Methods · Quantitative Biology 2025-10-10 Hsin-Pei Yu , Si-Qin Lyu , Yi-Hsien Hsieh , Weichung Wang , Tung-Hung Su , Jia-Horng Kao , Che Lin

Accurate breast lesion risk estimation can significantly reduce unnecessary biopsies and help doctors decide optimal treatment plans. Most existing computer-aided systems rely solely on mammogram features to classify breast lesions. While…

Image and Video Processing · Electrical Eng. & Systems 2021-08-24 Hung Q. Vo , Pengyu Yuan , Tiancheng He , Stephen T. C. Wong , Hien V. Nguyen

Multimodal learning that integrates histopathology images and genomic data holds great promise for cancer survival prediction. However, existing methods face key limitations: 1) They rely on multimodal mapping and metrics in Euclidean…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Jiaqi Yang , Wenting Chen , Xiaohan Xing , Sean He , Xiaoling Luo , Xinheng Lyu , Linlin Shen , Guoping Qiu

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Multimodal AI has demonstrated superior performance over unimodal approaches by leveraging diverse data sources for more comprehensive analysis. However, applying this effectiveness in healthcare is challenging due to the limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Pranav Poudel , Prashant Shrestha , Sanskar Amgain , Yash Raj Shrestha , Prashnna Gyawali , Binod Bhattarai

Pulmonary diseases can cause severe respiratory problems, leading to sudden death if not treated timely. Many researchers have utilized deep learning systems to diagnose pulmonary disorders using chest X-rays (CXRs). However, such systems…

Image and Video Processing · Electrical Eng. & Systems 2022-01-17 Mehreen Sirshar , Taimur Hassan , Muhammad Usman Akram , Shoab Ahmed Khan

Recent advances in computational pathology and artificial intelligence have significantly enhanced the utilization of gigapixel whole-slide images and and additional modalities (e.g., genomics) for pathological diagnosis. Although deep…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Qichen Sun , Zhengrui Guo , Rui Peng , Hao Chen , Jinzhuo Wang

Clinical machine learning models are increasingly trained using large scale, multimodal foundation paradigms, yet deployment environments often differ systematically from the data generating settings used during training. Such shifts arise…

Machine Learning · Computer Science 2026-03-10 Yuanyun Zhang , Shi Li

Survival prediction of cancers is crucial for clinical practice, as it informs mortality risks and influences treatment plans. However, a static model trained on a single dataset fails to adapt to the dynamically evolving clinical…

Machine Learning · Computer Science 2026-01-21 Dianzhi Yu , Conghao Xiong , Yankai Chen , Wenqian Cui , Xinni Zhang , Yifei Zhang , Hao Chen , Joseph J. Y. Sung , Irwin King

Multimodal learning leverages complementary information derived from different modalities, thereby enhancing performance in medical image segmentation. However, prevailing multimodal learning methods heavily rely on extensive well-annotated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Xiaogen Zhou , Yiyou Sun , Min Deng , Winnie Chiu Wing Chu , Qi Dou

The prediction of adaptive radiation therapy (ART) prior to radiation therapy (RT) for nasopharyngeal carcinoma (NPC) patients is important to reduce toxicity and prolong the survival of patients. Currently, due to the complex tumor…

Computer Vision and Pattern Recognition · Computer Science 2022-10-28 Jiabao Sheng , Yuanpeng Zhang , Jing Cai , Sai-Kit Lam , Zhe Li , Jiang Zhang , Xinzhi Teng

Rationale and Objectives: Early prediction of pathological complete response (pCR) can facilitate personalized treatment for breast cancer patients. To improve prediction accuracy at the early time point of neoadjuvant chemotherapy, we…

Computer Vision and Pattern Recognition · Computer Science 2025-02-04 Bowen Jing , Jing Wang

Clear cell renal cell carcinoma (ccRCC) exhibits extensive intratumoral heterogeneity on multiple biological scales, contributing to variable clinical outcomes and limiting the effectiveness of conventional TNM staging, which highlights the…

Quantitative Methods · Quantitative Biology 2025-12-18 Ying Cui , Dongzhe Zheng , Ke Yu , Xiyin Zheng , Xiaorui Wang , Xinxiang Li , Yan Gu , Lin Fu , Xinyi Chen , Wenjie Mei , Xin-Gui Peng