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In this paper, we introduce, MultiGA, an optimization framework which applies genetic algorithm principles to address complex natural language tasks and reasoning problems by sampling from a diverse population of LLMs to initialize the…

Neural and Evolutionary Computing · Computer Science 2026-04-03 Isabelle Diana May-Xin Ng , Tharindu Cyril Weerasooriya , Haitao Zhu , Wei Wei

Morphological attributes from histopathological images and molecular profiles from genomic data are important information to drive diagnosis, prognosis, and therapy of cancers. By integrating these heterogeneous but complementary data, many…

Machine Learning · Computer Science 2022-02-28 Kaiwen Tan , Weixian Huang , Xiaofeng Liu , Jinlong Hu , Shoubin Dong

The identification of cancer genes is a critical yet challenging problem in cancer genomics research. Existing computational methods, including deep graph neural networks, fail to exploit the multilayered gene-gene interactions or provide…

Machine Learning · Computer Science 2023-05-04 Michail Chatzianastasis , Michalis Vazirgiannis , Zijun Zhang

Training deep learning models on limited data while maintaining generalization is one of the fundamental challenges in molecular property prediction. One effective solution is transferring knowledge extracted from abundant datasets to those…

Machine Learning · Computer Science 2024-09-26 Soorin Yim , Dae-Woong Jeong , Sung Moon Ko , Sumin Lee , Hyunseung Kim , Chanhui Lee , Sehui Han

Domain adaptive detection aims to improve the generalization of detectors on target domain. To reduce discrepancy in feature distributions between two domains, recent approaches achieve domain adaption through feature alignment in different…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Libo Zhang , Wenzhang Zhou , Heng Fan , Tiejian Luo , Haibin Ling

This study introduces a framework that integrates nonlinear feature extraction, classification, and efficient optimization. First, kernel principal component analysis with a radial basis function kernel reduces dimensionality while…

Machine Learning · Computer Science 2025-06-23 Iliyas Ibrahim Iliyas , Souley Boukari , Abdulsalam Yau Gital

Multi-Modal Relation Extraction (MMRE) aims at identifying the relation between two entities in texts that contain visual clues. Rich visual content is valuable for the MMRE task, but existing works cannot well model finer associations…

Computation and Language · Computer Science 2023-06-21 Qian Li , Shu Guo , Cheng Ji , Xutan Peng , Shiyao Cui , Jianxin Li

Accurate identification of protein binding sites is crucial for understanding biomolecular interaction mechanisms and for the rational design of drug targets. Traditional predictive methods often struggle to balance prediction accuracy with…

Machine Learning · Computer Science 2026-01-06 Weisen Yang , Hanqing Zhang , Wangren Qiu , Xuan Xiao , Weizhong Lin

Transfer Optimization is an incipient research area dedicated to solving multiple optimization tasks simultaneously. Among the different approaches that can address this problem effectively, Evolutionary Multitasking resorts to concepts…

Neural and Evolutionary Computing · Computer Science 2021-05-04 Eneko Osaba , Javier Del Ser , Aritz D. Martinez , Jesus L. Lobo , Francisco Herrera

Enzyme mining is rapidly evolving as a data-driven strategy to identify biocatalysts with tailored functions from the vast landscape of uncharacterized proteins. The integration of machine learning into these workflows enables…

Biomolecules · Quantitative Biology 2025-07-11 Yanzi Zhang , Felix Moorhoff , Sizhe Qiu , Wenjuan Dong , David Medina-Ortiz , Jing Zhao , Mehdi D. Davari

This paper introduces Multi-population Ensemble Genetic Programming (MEGP), a computational intelligence framework that integrates cooperative coevolution and the multiview learning paradigm to address classification challenges in…

Neural and Evolutionary Computing · Computer Science 2025-09-25 Mohammad Sadegh Khorshidi , Navid Yazdanjue , Hassan Gharoun , Mohammad Reza Nikoo , Fang Chen , Amir H. Gandomi

Workforce scheduling in the healthcare sector is a significant operational challenge, characterized by fluctuating patient loads, diverse clinical skills, and the critical need to control labor costs while upholding high standards of…

Artificial Intelligence · Computer Science 2025-08-29 Vipul Patel , Anirudh Deodhar , Dagnachew Birru

Structure-based drug design (SBDD) aims to discover drug candidates by finding molecules (ligands) that bind tightly to a disease-related protein (targets), which is the primary approach to computer-aided drug discovery. Recently, applying…

Quantitative Methods · Quantitative Biology 2022-12-01 Tianfan Fu , Wenhao Gao , Connor W. Coley , Jimeng Sun

Artificial Intelligence predicts drug properties by encoding drug molecules, aiding in the rapid screening of candidates. Different molecular representations, such as SMILES and molecule graphs, contain complementary information for…

Machine Learning · Computer Science 2024-06-27 Muzhen Cai , Sendong Zhao , Haochun Wang , Yanrui Du , Zewen Qiang , Bing Qin , Ting Liu

Predicting drug-target binding affinity (DTA) is essential for identifying potential therapeutic candidates in drug discovery. However, most existing models rely heavily on static protein structures, often overlooking the dynamic nature of…

Robotics · Computer Science 2025-05-20 Dan Luo , Jinyu Zhou , Le Xu , Sisi Yuan , Xuan Lin

With the rapid advances of image editing techniques in recent years, image manipulation detection has attracted considerable attention since the increasing security risks posed by tampered images. To address these challenges, a novel…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Fengsheng Wang , Leyi Wei

Traditional deep learning methods in medical imaging often focus solely on segmentation or classification, limiting their ability to leverage shared information. Multi-task learning (MTL) addresses this by combining both tasks through…

Image and Video Processing · Electrical Eng. & Systems 2024-12-03 Phuoc-Nguyen Bui , Duc-Tai Le , Junghyun Bum , Hyunseung Choo

Protein-protein interaction (PPI) network alignment is a canonical operation to transfer biological knowledge among species. The alignment of PPI-networks has many applications, such as the prediction of protein function, detection of…

Molecular Networks · Quantitative Biology 2019-05-15 Ehsan Kazemi , Matthias Grossglauser

Deep neural networks trained for predicting cellular events from DNA sequence have become emerging tools to help elucidate the biological mechanism underlying the associations identified in genome-wide association studies. To enhance the…

Machine Learning · Computer Science 2022-09-27 Mohammad Shiri , Jiangwen Sun

Generative modeling and representation learning are two key tasks in computer vision. However, these models are typically trained independently, which ignores the potential for each task to help the other, and leads to training and model…

Computer Vision and Pattern Recognition · Computer Science 2023-07-03 Tianhong Li , Huiwen Chang , Shlok Kumar Mishra , Han Zhang , Dina Katabi , Dilip Krishnan