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Hyperscaling of data and parameter count in LLMs is yielding diminishing improvement when weighed against training costs, underlining a growing need for more efficient finetuning and inference without sacrificing performance. This is…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Moulik Choraria , Xinbo Wu , Akhil Bhimaraju , Nitesh Sekhar , Yue Wu , Xu Zhang , Prateek Singhal , Lav R. Varshney

Multimodal Large Language Models (MLLMs) rely on strong linguistic reasoning inherited from their base language models. However, multimodal instruction fine-tuning paradoxically degrades this text's reasoning capability, undermining…

Computation and Language · Computer Science 2026-01-13 Zijing Wang , Yongkang Liu , Mingyang Wang , Ercong Nie , Deyuan Chen , Zhengjie Zhao , Shi Feng , Daling Wang , Xiaocui Yang , Yifei Zhang , Hinrich Schütze

Multimodal deep learning (MDL) has emerged as a transformative approach in computational pathology. By integrating complementary information from multiple data sources, MDL models have demonstrated superior predictive performance across…

Quantitative Methods · Quantitative Biology 2025-11-17 Seth Alain Chang , Muhammad Mueez Amjad , Noorul Wahab , Ethar Alzaid , Nasir Rajpoot , Adam Shephard

We present ReMatch, a framework that leverages the generative strength of MLLMs for multimodal retrieval. Previous approaches treated an MLLM as a simple encoder, ignoring its generative nature, and under-utilising its compositional…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Qianying Liu , Xiao Liang , Zhiqiang Zhang , Zhongfei Qing , Fengfan Zhou , Yibo Chen , Xu Tang , Yao Hu , Paul Henderson

Multimodal large language models (MLLMs) have seen substantial progress in recent years. However, their ability to represent multimodal information in the acoustic domain remains underexplored. In this work, we introduce Vela, a novel…

Information Retrieval · Computer Science 2025-06-18 Ruofan Hu , Yan Xia , Minjie Hong , Jieming Zhu , Bo Chen , Xiaoda Yang , Minghui Fang , Tao Jin

Model merging has emerged as a key technique for enhancing the capabilities and efficiency of Large Language Models (LLMs). The open-source community has driven model evolution by iteratively merging existing models, yet a principled…

Computation and Language · Computer Science 2025-09-24 Yedi Hu , Yunzhi Yao , Ningyu Zhang , Huajun Chen , Shumin Deng

Recent advancements in Multimodal Large Language Models (MLLMs) have significantly enhanced performance on 2D visual tasks. However, improving their spatial intelligence remains a challenge. Existing 3D MLLMs always rely on additional 3D or…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Diankun Wu , Fangfu Liu , Yi-Hsin Hung , Yueqi Duan

Scientific reasoning, the process through which humans apply logic, evidence, and critical thinking to explore and interpret scientific phenomena, is essential in advancing knowledge reasoning across diverse fields. However, despite…

Computation and Language · Computer Science 2026-04-21 Yibo Yan , Shen Wang , Jiahao Huo , Jingheng Ye , Zhendong Chu , Xuming Hu , Philip S. Yu , Carla Gomes , Bart Selman , Qingsong Wen

Large language models (LLMs) have shown remarkable promise but remain challenging to continually improve through traditional finetuning, particularly when integrating capabilities from other specialized LLMs. Popular methods like ensemble…

Computation and Language · Computer Science 2025-06-02 Zhenglun Kong , Zheng Zhan , Shiyue Hou , Yifan Gong , Xin Meng , Pengwei Sui , Peiyan Dong , Xuan Shen , Zifeng Wang , Pu Zhao , Hao Tang , Stratis Ioannidis , Yanzhi Wang

Intelligently reasoning about the world often requires integrating data from multiple modalities, as any individual modality may contain unreliable or incomplete information. Prior work in multimodal learning fuses input modalities only…

Machine Learning · Computer Science 2020-11-17 George Barnum , Sabera Talukder , Yisong Yue

Machine learning is increasingly recognized as a promising technology in the biological, biomedical, and behavioral sciences. There can be no argument that this technique is incredibly successful in image recognition with immediate…

Molecular dynamics (MD) enables the study of physical systems with excellent spatiotemporal resolution but suffers from severe time-scale limitations. To address this, enhanced sampling methods have been developed to improve exploration of…

Statistical Mechanics · Physics 2023-06-19 Shams Mehdi , Zachary Smith , Lukas Herron , Ziyue Zou , Pratyush Tiwary

Large Language Models (LLMs) have become a cornerstone in Natural Language Processing (NLP), achieving impressive performance in text generation. Their token-level representations capture rich, human-aligned semantics. However, pooling…

Computation and Language · Computer Science 2025-09-25 Benedikt Roth , Stephan Rappensperger , Tianming Qiu , Hamza Imamović , Julian Wörmann , Hao Shen

In recent years, Multimodal Large Language Models (MLLMs) have achieved remarkable progress on a wide range of multimodal benchmarks. Despite these advances, most existing benchmarks mainly focus on single-image or multi-image…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Bingli Wang , Huanze Tang , Haijun Lv , Zhishan Lin , Lixin Gu , Lei Feng , Qipeng Guo , Kai Chen

Large Language Models (LLMs) have reshaped our world with significant advancements in science, engineering, and society through applications ranging from scientific discoveries and medical diagnostics to Chatbots. Despite their ubiquity and…

Artificial Intelligence · Computer Science 2025-08-26 Kushal Raj Bhandari , Pin-Yu Chen , Jianxi Gao

With hundreds of thousands of language models available on Huggingface today, efficiently evaluating and utilizing these models across various downstream, tasks has become increasingly critical. Many existing methods repeatedly learn…

Computation and Language · Computer Science 2024-10-18 Richard Zhuang , Tianhao Wu , Zhaojin Wen , Andrew Li , Jiantao Jiao , Kannan Ramchandran

Predicting patient features from single-cell data can help identify cellular states implicated in health and disease. Linear models and average cell type expressions are typically favored for this task for their efficiency and robustness,…

Machine Learning · Computer Science 2024-03-11 Jan P. Engelmann , Alessandro Palma , Jakub M. Tomczak , Fabian J. Theis , Francesco Paolo Casale

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Large language models have been adopted in the medical domain for clinical documentation to reduce clinician burden. However, studies have reported that LLMs often "forget" a significant amount of instruction-following ability when…

Computation and Language · Computer Science 2026-04-03 Mengxian Lyu , Cheng Peng , Ziyi Chen , Mengyuan Zhang , Jieting Li Lu , Yonghui Wu

Multimodal embeddings are widely used in downstream tasks such as multimodal retrieval, enabling alignment of interleaved modalities in a shared representation space. While recent studies show that Multimodal Large Language Models (MLLMs)…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Chunxu Liu , Jiyuan Yang , Ruopeng Gao , Yuhan Zhu , Feng Zhu , Rui Zhao , Limin Wang