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Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the…

Quantum Physics · Physics 2024-05-17 Qi-Ming Ding , Yi-Ming Huang , Xiao Yuan

The quantum approximate optimization algorithm (QAOA) transforms a simple many-qubit wavefunction into one which encodes a solution to a difficult classical optimization problem. It does this by optimizing the schedule according to which…

Quantum Physics · Physics 2022-06-29 Yunlong Yu , Chenfeng Cao , Carter Dewey , Xiang-Bin Wang , Nic Shannon , Robert Joynt

Quantum computers are expected to offer significant advantages in solving complex optimization problems that are challenging for classical computers. Quadratic Unconstrained Binary Optimization (QUBO) problems represent an important class…

Quantum Physics · Physics 2025-10-15 Teemu Pihkakoski , Aravind Plathanam Babu , Pauli Taipale , Petri Liimatta , Matti Silveri

Decoding Low-Density Parity-Check (LDPC) codes is a fundamental problem in coding theory, and Belief Propagation (BP) is one of the most popular methods for LDPC code decoding. However, BP may encounter convergence issues and suboptimal…

Quantum Physics · Physics 2026-02-25 Krishnakanta Barik , Goutam Paul

Combinatorial optimization problems are ubiquitous and computationally hard to solve in general. Quantum approximate optimization algorithm (QAOA), one of the most representative quantum-classical hybrid algorithms, is designed to solve…

Quantum Physics · Physics 2024-03-12 Lixue Cheng , Yu-Qin Chen , Shi-Xin Zhang , Shengyu Zhang

The Quantum approximate optimization algorithm (QAOA) is a quantum-classical hybrid algorithm aiming to produce approximate solutions for combinatorial optimization problems. In the QAOA, the quantum part prepares a quantum parameterized…

Quantum Physics · Physics 2024-04-23 Ningyi Xie , Xinwei Lee , Dongsheng Cai , Yoshiyuki Saito , Nobuyoshi Asai

Parameterized quantum circuits are attractive candidates for potential quantum advantage in the near term and beyond. At the same time, as quantum computing hardware not only continues to improve but also begins to incorporate new features…

Quantum Physics · Physics 2024-03-19 Tobias Stollenwerk , Stuart Hadfield

Efficient spectrum sharing in the Citizens Broadband Radio Service (CBRS) band is essential for maximizing 5G network capacity, particularly when high-traffic base stations require simultaneous access to multiple channels. Standard…

Quantum Physics · Physics 2026-01-26 Gunsik Min , Youngjin Seo , Jun Heo

The development of edge computing places critical demands on energy-efficient model deployment for multiple-input multiple-output (MIMO) detection tasks. Deploying deep unfolding models such as PGD-Nets and ADMM-Nets into…

Machine Learning · Computer Science 2025-05-20 Zeyi Ren , Jingreng Lei , Yichen Jin , Ermo Hua , Qingfeng Lin , Chen Zhang , Bowen Zhou , Yik-Chung Wu

Although quantum approximate optimization algorithm (QAOA) has demonstrated its quantum supremacy, its performance on Noisy Intermediate-Scale Quantum (NISQ) devices would be influenced by complicated noises, e.g., quantum colored noises.…

Quantum Physics · Physics 2023-09-04 Bo Yue , Shibei Xue , Yu Pan , Min Jiang

The Quantum Approximate Optimization Algorithm (QAOA), which is a variational quantum algorithm, aims to give sub-optimal solutions of combinatorial optimization problems. It is widely believed that QAOA has the potential to demonstrate…

Constrained combinatorial optimization with strict linear constraints underpins applications in drug discovery, power grids, logistics, and finance, yet remains computationally demanding for classical algorithms, especially at large scales.…

Quantum Physics · Physics 2026-04-07 Yajie Hao , Qiming Ding , Xiao Yuan , Xiaoting Wang

The Quantum Approximate Optimization Algorithm (QAOA) is a hybrid quantum-classical variational algorithm designed to tackle combinatorial optimization problems. Despite its promise for near-term quantum applications, not much is currently…

Quantum Physics · Physics 2020-06-26 Leo Zhou , Sheng-Tao Wang , Soonwon Choi , Hannes Pichler , Mikhail D. Lukin

Quantum algorithms must be scaled up to tackle real-world applications. Doing so requires overcoming the noise present on today's hardware. The quantum approximate optimization algorithm (QAOA) is a promising candidate for scaling up, due…

Quantum Physics · Physics 2026-02-23 Zichang He , David Amaro , Ruslan Shaydulin , Marco Pistoia

Variational Quantum Algorithms (VQAs), such as the Quantum Approximate Optimization Algorithm (QAOA), offer a promising route to tackling combinatorial optimization problems on near and intermediate-term quantum devices. However, their…

Quantum Physics · Physics 2026-02-17 Dhanvi Bharadwaj , Yuewen Hou , Guang-Yi Li , Gokul Subramanian Ravi

Developing quantum algorithms adaptive to specific constraints of near-term devices is an essential step towards practical quantum advantage. In a recent work [Phys. Rev. Lett. 131, 103601(2023)], we show cold atoms in an optical cavity can…

Quantum Physics · Physics 2024-06-12 Yuchen Luo , Xiaopeng Li , Jian Lin

The Quantum Approximate Optimization Algorithm (QAOA) is a variational quantum algorithm that can be used to approximately solve combinatorial optimization problems. However, a major limitation of QAOA is that it is a "local" algorithm for…

Quantum Physics · Physics 2025-04-10 Quinn Langfitt , Reuben Tate , Stephan Eidenbenz

The Quantum Approximate Optimization Algorithm (QAOA) is a leading framework for quantum combinatorial optimization. The Vehicle Routing Problem (VRP), a core problem in logistics and transportation, is a natural application target, but it…

Emerging Technologies · Computer Science 2026-04-09 Yuan-Zheng Lei , Yaobang Gong , Xianfeng Terry Yang , Nii Attoh-Okine

The Quantum Approximate Optimization Algorithm (QAOA) is a quantum-classical hybrid algorithm intending to find the ground state of a target Hamiltonian. Theoretically, QAOA can obtain the approximate solution if the quantum circuit is deep…

Quantum Physics · Physics 2022-04-26 Yahui Chai , Yong-Jian Han , Yu-Chun Wu , Ye Li , Menghan Dou , Guo-Ping Guo

Discovering configurations that are both high-utility and structurally diverse under expensive black-box evaluation and strict query budgets remains a central challenge in data-driven discovery. Many classical optimizers concentrate on…

Quantum Physics · Physics 2026-02-11 Saisubramaniam Gopalakrishnan , Dagnachew Birru