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Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

Computation and Language · Computer Science 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

Large Language Model (LLM)-based recommendation systems have demonstrated remarkable capabilities in understanding user preferences and generating personalized suggestions. However, existing approaches face critical challenges in…

Information Retrieval · Computer Science 2026-04-24 Sushant Mehta

While interpretable prototype networks offer compelling case-based reasoning for clinical diagnostics, their raw continuous outputs lack the semantic structure required for medical documentation. Bridging this gap via standard…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Alvaro Lopez Pellicer , Plamen Angelov , Marwan Bukhari , Yi Li , Eduardo Soares , Jemma Kerns

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

Artificial Intelligence · Computer Science 2026-03-02 Wenliang Li , Rui Yan , Xu Zhang , Li Chen , Hongji Zhu , Jing Zhao , Junjun Li , Mengru Li , Wei Cao , Zihang Jiang , Wei Wei , Kun Zhang , Shaohua Kevin Zhou

Accurate prediction of traffic crash severity is critical for improving emergency response and public safety planning. Although recent large language models (LLMs) exhibit strong reasoning capabilities, their single-agent architectures…

Artificial Intelligence · Computer Science 2026-02-03 Zhichao Yang , Jiashu He , Jinxuan Fan , Cirillo Cinzia

Background: Cognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field. Objective: This study…

Computation and Language · Computer Science 2024-05-14 Yu He Ke , Rui Yang , Sui An Lie , Taylor Xin Yi Lim , Hairil Rizal Abdullah , Daniel Shu Wei Ting , Nan Liu

Assessing the veracity of online content has become increasingly critical. Large language models (LLMs) have recently enabled substantial progress in automated veracity assessment, including automated fact-checking and claim verification…

Computation and Language · Computer Science 2026-04-14 Yupeng Cao , Chengyang He , Yangyang Yu , Ping Wang , K. P. Subbalakshmi

Artificial intelligence has shown promise in medical imaging, yet most existing systems lack flexibility, interpretability, and adaptability - challenges especially pronounced in ophthalmology, where diverse imaging modalities are…

Large Language Model (LLM)-based agents have recently shown impressive capabilities in complex reasoning and tool use via multi-step interactions with their environments. While these agents have the potential to tackle complicated tasks,…

Artificial Intelligence · Computer Science 2025-11-04 Jiaye Lin , Yifu Guo , Yuzhen Han , Sen Hu , Ziyi Ni , Licheng Wang , Mingguang Chen , Hongzhang Liu , Ronghao Chen , Yangfan He , Daxin Jiang , Binxing Jiao , Chen Hu , Huacan Wang

Limited access to mental healthcare, extended wait times, and increasing capabilities of Large Language Models (LLMs) has led individuals to turn to LLMs for fulfilling their mental health needs. However, examining the multi-turn mental…

Computation and Language · Computer Science 2025-05-29 Mohit Chandra , Siddharth Sriraman , Harneet Singh Khanuja , Yiqiao Jin , Munmun De Choudhury

Large language models (LLMs) exhibit strong symbolic and compositional reasoning, yet they struggle with time series question answering as the data is typically transformed into an LLM-compatible modality, e.g., serialized text, plotted…

Artificial Intelligence · Computer Science 2026-04-08 Penghang Liu , Elizabeth Fons , Annita Vapsi , Mohsen Ghassemi , Svitlana Vyetrenko , Daniel Borrajo , Vamsi K. Potluru , Manuela Veloso

Large Language Models (LLMs) achieve competitive results compared to human experts in medical examinations. However, it remains a challenge to apply LLMs to complex clinical decision-making, which requires a deep understanding of medical…

Video understanding is fundamental to tasks such as action recognition, video reasoning, and robotic control. Early video understanding methods based on large vision-language models (LVLMs) typically adopt a single-pass reasoning paradigm…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Yiyang Zhou , Yangfan He , Yaofeng Su , Siwei Han , Joel Jang , Gedas Bertasius , Mohit Bansal , Huaxiu Yao

Large Language Models (LLMs) have been successful in mathematical reasoning tasks such as formal theorem proving when integrated with interactive proof assistants like Lean. Existing approaches involve training or fine-tuning an LLM on a…

Machine Learning · Computer Science 2025-03-07 Adarsh Kumarappan , Mo Tiwari , Peiyang Song , Robert Joseph George , Chaowei Xiao , Anima Anandkumar

Humans solve problems by executing targeted plans, yet large language models (LLMs) remain unreliable for structured workflow execution. We propose RunAgent, a multi-agent plan execution platform that interprets natural-language plans while…

Machine Learning · Computer Science 2026-05-04 Arunabh Srivastava , Mohammad A. , Khojastepour , Srimat Chakradhar , Sennur Ulukus

Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are both effective and biologically safe remains a major bottleneck. In practical screening, toxicity is a…

Artificial Intelligence · Computer Science 2026-05-26 Leshu Li , An Lu , Haiyu Wang , Zhibin Feng , Conghui Duan , Qing Bao , Zongmin Zhao , Sai Qian Zhang

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

Large Language Models (LLMs) can extend their parameter knowledge limits by adopting the Tool-Integrated Reasoning (TIR) paradigm. However, existing LLM-based agent training framework often focuses on answers' accuracy, overlooking specific…

Artificial Intelligence · Computer Science 2026-01-21 Yifei Chen , Guanting Dong , Zhicheng Dou

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Large Language Model (LLM) web agents often struggle with long-horizon web navigation and web task completion in new websites, producing inefficient action sequences unless fine-tuned on environment-specific data. We show that…