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Deep learning has become a powerful tool in computational biology, revolutionising the analysis and interpretation of biological data over time. In our article review, we delve into various aspects of deep learning in computational biology.…

Computational models are quantitative representations of systems. By analyzing and comparing the outputs of such models, it is possible to gain a better understanding of the system itself. Though as the complexity of model outputs…

Machine Learning · Computer Science 2022-12-13 Colin G. Cess , Stacey D. Finley

The key to success in machine learning (ML) is the use of effective data representations. Traditionally, data representations were hand-crafted. Recently it has been demonstrated that, given sufficient data, deep neural networks can learn…

Machine Learning · Computer Science 2018-11-09 Ivan Olier , Oghenejokpeme I. Orhobor , Joaquin Vanschoren , Ross D. King

With the growth of artificial intelligence (AI), there has been an increase in the adoption of computer vision and deep learning (DL) techniques for the evaluation of microscopy images and movies. This adoption has not only addressed…

Quantitative Methods · Quantitative Biology 2023-07-21 Binghao Chai , Christoforos Efstathiou , Haoran Yue , Viji M. Draviam

When a facial image is blurred, it significantly affects high-level vision tasks such as face recognition. The purpose of facial image deblurring is to recover a clear image from a blurry input image, which can improve the recognition…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Bingnan Wang , Fanjiang Xu , Quan Zheng

For over two decades, image-based profiling has revolutionized cell phenotype analysis. Image-based profiling processes rich, high-throughput, microscopy data into thousands of unbiased measurements that reveal phenotypic patterns powerful…

Statistical shape modeling is the computational process of discovering significant shape parameters from segmented anatomies captured by medical images (such as MRI and CT scans), which can fully describe subject-specific anatomy in the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Krithika Iyer , Shireen Elhabian

Data generated by edge devices has the potential to train intelligent autonomous systems across various domains. Despite the emergence of diverse machine learning approaches addressing privacy concerns and utilizing distributed data,…

Machine Learning · Computer Science 2024-03-12 Adarsh N L , Arun P , Alok Porwal , Malcolm Aranha

Biomedical imaging is unequivocally dependent on the ability to reconstruct interpretable and high-quality images from acquired sensor data. This reconstruction process is pivotal across many applications, spanning from magnetic resonance…

Signal Processing · Electrical Eng. & Systems 2019-09-24 Ben Luijten , Regev Cohen , Frederik J. de Bruijn , Harold A. W. Schmeitz , Massimo Mischi , Yonina C. Eldar , Ruud J. G. van Sloun

Input space reconstruction is an attractive representation learning paradigm. Despite interpretability of the reconstruction and generation, we identify a misalignment between learning by reconstruction, and learning for perception. We show…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Randall Balestriero , Yann LeCun

Malignant melanoma is the deadliest form of skin cancer and, in recent years, is rapidly growing in terms of the incidence worldwide rate. The most effective approach to targeted treatment is early diagnosis. Deep learning algorithms,…

Image and Video Processing · Electrical Eng. & Systems 2020-09-21 Mario Manzo , Simone Pellino

Machine learning is increasingly recognized as a promising technology in the biological, biomedical, and behavioral sciences. There can be no argument that this technique is incredibly successful in image recognition with immediate…

Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Roarke Horstmeyer , Richard Y. Chen , Barbara Kappes , Benjamin Judkewitz

Recently, intermediate feature maps of pre-trained convolutional neural networks have shown significant perceptual quality improvements, when they are used in the loss function for training new networks. It is believed that these features…

Computer Vision and Pattern Recognition · Computer Science 2020-07-24 Taimoor Tariq , Okan Tarhan Tursun , Munchurl Kim , Piotr Didyk

Numerous cellular functions rely on protein$\unicode{x2013}$protein interactions. Efforts to comprehensively characterize them remain challenged however by the diversity of molecular recognition mechanisms employed within the proteome. Deep…

Biomolecules · Quantitative Biology 2023-12-08 Julia R. Rogers , Gergő Nikolényi , Mohammed AlQuraishi

We present a new approach for representing and reconstructing multidimensional magnetic resonance imaging (MRI) data. Our method builds on a novel, learned feature-based image representation that disentangles different types of features,…

Image and Video Processing · Electrical Eng. & Systems 2026-01-01 Ruiyang Zhao , Fan Lam

In deep metric learning (DML), high-level input data are represented in a lower-level representation (embedding) space, such that samples from the same class are mapped close together, while samples from disparate classes are mapped further…

Computer Vision and Pattern Recognition · Computer Science 2023-04-03 Ryan Furlong , Vincent O'Brien , James Garland , Daniel Palacios-Alonso , Francisco Dominguez-Mateos

Medical ultrasound imaging relies heavily on high-quality signal processing to provide reliable and interpretable image reconstructions. Conventionally, reconstruction algorithms where derived from physical principles. These algorithms rely…

Signal Processing · Electrical Eng. & Systems 2023-09-21 Ben Luijten , Nishith Chennakeshava , Yonina C. Eldar , Massimo Mischi , Ruud J. G. van Sloun

Masked Image Modeling (MIM) achieves outstanding success in self-supervised representation learning. Unfortunately, MIM models typically have huge computational burden and slow learning process, which is an inevitable obstacle for their…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Haoqing Wang , Yehui Tang , Yunhe Wang , Jianyuan Guo , Zhi-Hong Deng , Kai Han

Deep learning is catalyzing a scientific revolution fueled by big data, accessible toolkits, and powerful computational resources, impacting many fields including protein structural modeling. Protein structural modeling, such as predicting…

Biomolecules · Quantitative Biology 2020-07-17 Wenhao Gao , Sai Pooja Mahajan , Jeremias Sulam , Jeffrey J. Gray