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Objectives: Magnetic resonance elastography (MRE) is a noninvasive technique for assessing the viscoelastic properties of soft biological tissues in vivo, with potential relevance for pediatric tumor evaluation. This study aimed to evaluate…

Magnetic Resonance Elastography (MRE) noninvasively maps brain biomechanics and is highly sensitive to alterations associated with aging and neurodegenerative disease. Most implementations use a single frequency or a narrow frequency band,…

In the framework of algebraic inversion, Magnetic Resonance Elastography (MRE) repeatability, reproducibility and robustness were evaluated on extracted shear velocities (or elastic moduli). The same excitation system was implemented at two…

Optical coherence elastography (OCE) is a powerful non-invasive imaging technique for high-resolution assessment of tissue elasticity and viscoelasticity. Accurate characterization of viscoelastic properties requires estimating shear wave…

Mechanical models of brain tissue are a beneficial tool to simulate neurosurgical interventions, disease progression, or brain development. However, the accuracy and predictive capacity of such a model relies on a precise experimental…

Medical Physics · Physics 2026-05-29 Laura Ruhland , Nina Reiter , Silvia Budday , Kai Willner

Magnetic Resonance Elastography (MRE) has become an essential tool in assessing the mechanical properties of soft tissues in-vivo, prompting significant progress in new inversion algorithms. This creates a need for a benchmarking framework…

Numerical Analysis · Mathematics 2026-04-06 Yashasvi Verma , Jakob Schattenfroh , Ingolf Sack , Silvia Budday , Paul Steinmann , Luca Heltai

As disease often alters the structural properties of soft tissue, noninvasive elastography techniques have emerged to quantitatively assess in vivo mechanical properties. Magnetic Resonance Elastography (MRE) based on dynamic deformations…

A rising wave of technologies and instruments are enabling more labs and clinics to make a variety of measurements related to tissue viscoelastic properties. These instruments include elastography imaging scanners, rheological shear…

Tissues and Organs · Quantitative Biology 2024-08-30 Kevin J. Parker , Thomas Szabo , Sverre Holm

We have developed a new technique to measure viscoelasticity in soft materials such as polymer solutions, by monitoring thermal fluctuations of embedded probe particles using laser interferometry in a microscope. Interferometry allows us to…

Soft Condensed Matter · Physics 2009-10-30 B. Schnurr , F. Gittes , F. C. MacKintosh , C. F. Schmidt

Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their…

Applied Physics · Physics 2023-04-14 Parameshwaran Pasupathy , John G Georgiadis , Assimina A Pelegri

Minimally invasive experimental methods that can measure local rate dependent mechanical properties are essential in understanding the behaviour of soft and biological materials in a wide range of applications. Needle based measurement…

Soft Condensed Matter · Physics 2020-10-20 S Chockalingam , Christine Roth , Thomas Henzel , Tal Cohen

Cuffless blood pressure (BP) estimation based on Pulse Transit Time (PTT) has emerged as a promising solution for continuous health monitoring. However, conventional models relying on the Moens-Korteweg equation often fail during rapid…

Human-Computer Interaction · Computer Science 2026-05-01 Boyuan Gu , Yijin Yang , Shuaiqi Cheng , Xiaorong Ding

We measure the mechanical thermal noise of soft silicon atomic force microscopy cantilevers. Using an interferometric setup, we have a resolution down to 1E-14 m/rtHz on a wide spectral range (3 Hz to 1E5 Hz). The low frequency behavior…

Materials Science · Physics 2009-09-25 Pierdomenico Paolino , Ludovic Bellon

Abstract Knowledge of the evolution of mechanical properties of the curing matrix is of great importance in composite parts or structure fabrication. Conventional rheometry, based on small amplitude oscillatory shear is limited by long…

Soft Condensed Matter · Physics 2024-05-14 Thanasis Athanasiou , Michela Geri , Patrice Roose , Gareth H. McKinley , George Petekidis

Objective: This paper presents a force control scheme for brief isotonic holds in an isometrically contracted muscle tissue, with minimal overshoot and settling time to measure its shortening velocity, a key parameter of muscle function.…

Systems and Control · Electrical Eng. & Systems 2022-07-29 Amanda Bianco , Raphael Zonis , Anne-Marie Lauzon , James Richard Forbes , Gijs Ijpma

Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…

Soft Condensed Matter · Physics 2025-12-23 G. Small , F. Ballatore , C. Giverso , V. Balbi

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in…

Vertebral fractures prediction in clinics lacks of accuracy. The most used scores have limitations in distinguishing between subjects at risk or not. Finite element (FE) models generated from computed tomography (CT) of these patients may…

Computational Engineering, Finance, and Science · Computer Science 2024-02-16 Chiara Garavelli , Alessandra Aldieri , Marco Palanca , Luca Patruno , Marco Viceconti

Robust segmentation for non-elongated tissues in medical images is hard to realize due to the large variation of the shape, size, and appearance of these tissues in different patients. In this paper, we present an end-to-end trainable deep…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Qian Yu , Yinghuan Shi , Yefeng Zheng , Yang Gao , Jianbing Zhu , Yakang Dai

Magnetic resonance fingerprinting (MRF) is a technique for quantitative estimation of spin-relaxation parameters from magnetic-resonance data. Most current MRF approaches assume that only one tissue is present in each voxel, which neglects…

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