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Large language models (LLMs) show remarkable potential in scientific hypothesis discovery. However, existing approaches face two critical limitations: they treat divergent exploratory ideation and convergent fine-grained refinement as…

Computation and Language · Computer Science 2026-05-29 Hongran An , Zonglin Yang

We introduce a multicrossmodal LLM-agent framework motivated by the growing volume and diversity of materials-science data ranging from high-resolution microscopy and dynamic simulation videos to tabular experiment logs and sprawling…

Materials Science · Physics 2025-05-22 Adib Bazgir , Rama chandra Praneeth Madugula , Yuwen Zhang

The rapidly growing demand for high-quality data in Large Language Models (LLMs) has intensified the need for scalable, reliable, and semantically rich data preparation pipelines. However, current practices remain dominated by ad-hoc…

Large language models are moving scientific research from text assistance toward agentic workflows, yet biological research requires strong object validation, methodological suitability, reproducibility, and auditability. Prompt…

Quantitative Methods · Quantitative Biology 2026-05-25 Zhenyu Ma , Yuyang Song , Chunyi Yang , Jingyi Zhu , Limei Xu , Min Xiao , Xukai Jiang

Empirical conclusions depend not only on data but on analytic decisions made throughout the research process. Many-analyst studies have quantified this dependence: independent teams testing the same hypothesis on the same dataset regularly…

Artificial Intelligence · Computer Science 2026-03-12 Martin Bertran , Riccardo Fogliato , Zhiwei Steven Wu

Artificial intelligence (AI) has been increasingly applied in scientific activities for decades; however, it is still far from an insightful and trustworthy collaborator in the scientific process. Most existing AI methods are either too…

Artificial Intelligence · Computer Science 2022-02-08 Morad Behandish , John Maxwell , Johan de Kleer

Synthesizing knowledge from large document collections is a critical yet increasingly complex aspect of qualitative research and knowledge work. While AI offers automation potential, effectively integrating it into human-centric sensemaking…

Human-Computer Interaction · Computer Science 2026-02-06 Runlong Ye , Patrick Yung Kang Lee , Matthew Varona , Oliver Huang , Carolina Nobre

Scientific discovery is often slowed by the manual development of computational tools needed to analyze complex experimental data. Building such tools is costly and time-consuming because scientists must iteratively review literature, test…

Artificial Intelligence · Computer Science 2026-05-19 Alistair Turcan , Kexin Huang , Lei Li , Martin Jinye Zhang

Qualitative research emphasizes constructing meaning through iterative engagement with textual data. Traditionally this human-driven process requires navigating coder fatigue and interpretative drift, thus posing challenges when scaling…

Human-Computer Interaction · Computer Science 2025-12-16 Joseph Matveyenko , James Liu , John David Parsons , Ryan A. Brown , Alina Palimaru , Prateek Puri

The cognitive sciences aim to understand intelligence by formalizing underlying operations as computational models. Traditionally, this follows a cycle of discovery where researchers develop paradigms, collect data, and test predefined…

Artificial Intelligence · Computer Science 2026-03-24 Akshay K. Jagadish , Milena Rmus , Kristin Witte , Marvin Mathony , Marcel Binz , Eric Schulz

LLM-based agents are rapidly being adopted for scientific data analysis, automating tasks once limited by human time and expertise. This capability is often framed as an acceleration of discovery, but it also accelerates a familiar failure…

Artificial Intelligence · Computer Science 2026-05-21 Dionizije Fa , Marko Culjak

Artificial Intelligence is moving from models that only generate text to Agentic AI, where systems behave as autonomous entities that can perceive, reason, plan, and act. Large Language Models (LLMs) are no longer used only as passive…

Artificial Intelligence · Computer Science 2026-01-21 Arunkumar V , Gangadharan G. R. , Rajkumar Buyya

Scientific discovery evolves from the experimental, through the theoretical and computational, to the current data-intensive paradigm. Materials science is no exception, especially for computational materials science. In recent years, great…

Materials Science · Physics 2018-04-24 Tao Qiang , Honghong Gao

The adoption of large language models (LLMs) and autonomous agents in software engineering marks an enduring paradigm shift. These systems create new opportunities for tool design, workflow orchestration, and empirical observation, while…

Software Engineering · Computer Science 2025-11-04 Christoph Treude , Margaret-Anne Storey

Large Language Models (LLMs) like ChatGPT, DeepSeek and Gemini seem to be increasingly used for knowledge discovery, information retrieval, and knowledge summaries, including for academic topics. This can result in users being misled, such…

Information Retrieval · Computer Science 2026-05-28 Mike Thelwall

Developments in the field of Artificial Intelligence (AI), and particularly large language models (LLMs), have created a 'perfect storm' for observing 'sparks' of Artificial General Intelligence (AGI) that are spurious. Like simpler models,…

Artificial Intelligence · Computer Science 2024-06-03 Patrick Altmeyer , Andrew M. Demetriou , Antony Bartlett , Cynthia C. S. Liem

The emergence of AI Scientists has demonstrated remarkable potential in automating scientific research. However, current approaches largely conceptualize scientific discovery as a solitary optimization or search process, overlooking that…

Artificial Intelligence · Computer Science 2025-11-24 Qingbin Zeng , Bingbing Fan , Zhiyu Chen , Sijian Ren , Zhilun Zhou , Xuhua Zhang , Yuanyi Zhen , Fengli Xu , Yong Li , Tie-Yan Liu

The rapid growth of scientific literature makes it challenging for researchers to identify novel and impactful ideas, especially across disciplines. Modern artificial intelligence (AI) systems offer new approaches, potentially inspiring…

Artificial Intelligence · Computer Science 2025-01-09 Xuemei Gu , Mario Krenn

High-quality scientific review and perspective papers require substantial time and effort, limiting researchers' ability to synthesize emerging knowledge. While Large Language Models (LLMs) leverage AI Scientists for scientific workflows,…

Artificial Intelligence · Computer Science 2026-03-03 Sasi Kiran Gaddipati , Farhana Keya , Gollam Rabby , Sören Auer

With the advent of large language models (LLMs), in both the open source and proprietary domains, attention is turning to how to exploit such artificial intelligence (AI) systems in assisting complex scientific tasks, such as material…

Human-Computer Interaction · Computer Science 2024-01-26 Yongtao Liu , Marti Checa , Rama K. Vasudevan
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