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Prostate cancer (PCa) is graded by pathologists by examining the architectural pattern of cancerous epithelial tissue on hematoxylin and eosin (H&E) stained slides. Given the importance of gland morphology, automatically differentiating…

The performance of learning models often deteriorates when deployed in out-of-sample environments. To ensure reliable deployment, we propose a stability evaluation criterion based on distributional perturbations. Conceptually, our stability…

Machine Learning · Statistics 2024-05-07 Jose Blanchet , Peng Cui , Jiajin Li , Jiashuo Liu

We introduce Harmonic Robustness, a powerful and intuitive method to test the robustness of any machine-learning model either during training or in black-box real-time inference monitoring without ground-truth labels. It is based on…

Machine Learning · Computer Science 2024-04-30 Nicholas S. Kersting , Yi Li , Aman Mohanty , Oyindamola Obisesan , Raphael Okochu

Corrosion testing is slow, labor-intensive, and sensitive to operator technique, limiting the generation of large, high-quality datasets for data-driven materials discovery. The Materials Acceleration Platform for Electrochemistry (MAP-E)…

Accurate prediction of the likelihood of recurrence is important in the selection of postoperative treatment for patients with early-stage breast cancer. In this study, we investigated whether deep learning algorithms can predict patients'…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Geongyu Lee , Joonho Lee , Tae-Yeong Kwak , Sun Woo Kim , Youngmee Kwon , Chungyeul Kim , Hyeyoon Chang

Policies for Partially Observable Markov Decision Processes (POMDPs) are often designed using a nominal system model. In practice, this model can deviate from the true system during deployment due to factors such as calibration drift or…

Artificial Intelligence · Computer Science 2026-04-24 Benjamin Kraske , Qi Heng Ho , Federico Rossi , Morteza Lahijanian , Zachary Sunberg

Safety goes first. Meeting and maintaining industry safety standards for robustness of artificial intelligence (AI) and machine learning (ML) models require continuous monitoring for faults and performance drops. Deep learning models are…

Machine Learning · Computer Science 2023-02-03 Aria Khademi , Michael Hopka , Devesh Upadhyay

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

Computer Vision and Pattern Recognition · Computer Science 2021-11-30 Simon Graham , Mostafa Jahanifar , Quoc Dang Vu , Giorgos Hadjigeorghiou , Thomas Leech , David Snead , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining, serves as the benchmark for disease diagnosis and comprehensive clinical assessment of tissue. However, the process is laborious and time-consuming,…

Reactive chemistry of molecular hydrogen at surfaces, notably dissociative sticking and hydrogen evolution, plays a crucial role in energy storage and fuel cells. Theoretical studies can help to decipher underlying mechanisms and reaction…

Computer vision models are increasingly capable of classifying ovarian epithelial cancer subtypes, but they differ from pathologists by processing small tissue patches at a single resolution. Multi-resolution graph models leverage the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Jack Breen , Katie Allen , Kieran Zucker , Nicolas M. Orsi , Nishant Ravikumar

Cyber-physical system (CPS) forecasting models depend on sensor streams with noisy, biased, missing, or temporally misaligned readings, yet standard forecasting evaluation often selects models by nominal error without showing whether they…

Machine Learning · Computer Science 2026-05-12 Alexander Windmann , Philipp Wittenberg , Gianluca Manca , Marcel Dix , Jens U. Brandt , Oliver Niggemann

This research leverages Conformal Prediction (CP) in the form of Conformal Predictive Systems (CPS) to accurately estimate uncertainty in a suite of machine learning (ML)-based radio metric models [1] as well as in a 2-D map-based ML path…

Machine Learning · Computer Science 2025-01-14 Alexis Bose , Jonathan Ethier , Ryan G. Dempsey , Yifeng Qiu

The development of biologically interpretable and explainable models remains a key challenge in computational pathology, particularly for multistain immunohistochemistry (IHC) analysis. We present BioX-CPath, an explainable graph neural…

The performance of computer vision models are susceptible to unexpected changes in input images caused by sensor errors or extreme imaging environments, known as common corruptions (e.g. noise, blur, illumination changes). These corruptions…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Shunxin Wang , Raymond Veldhuis , Christoph Brune , Nicola Strisciuglio

Contrastive Language-Image Pre-training (CLIP) models have demonstrated remarkable generalization capabilities across multiple challenging distribution shifts. However, there is still much to be explored in terms of their robustness to the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Weijie Tu , Weijian Deng , Tom Gedeon

Preference learning in large language models relies on reward models as proxies for human judgment. However, these models frequently exhibit preference instability, producing contradictory preference assignments in response to subtle,…

Machine Learning · Computer Science 2026-05-19 Shunchang Liu , Xin Chen , Belen Martin Urcelay , Francesco Croce

Statistical models for networks with complex dependencies pose particular challenges for model selection and evaluation. In particular, many well-established statistical tools for selecting between models assume conditional independence of…

Methodology · Statistics 2019-08-20 Fan Yin , Nolan Edward Phillips , Carter T. Butts

Early event prediction (EEP) systems continuously estimate a patient's imminent risk to support clinical decision-making. For bedside trust, risk trajectories must be accurate and temporally stable, shifting only with new, relevant…

Machine Learning · Computer Science 2025-10-17 Mayank Keoliya , Seewon Choi , Rajeev Alur , Mayur Naik , Eric Wong