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An embodied agent assisting humans is often asked to complete new tasks, and there may not be sufficient time or labeled examples to train the agent to perform these new tasks. Large Language Models (LLMs) trained on considerable knowledge…

Drug-target interaction (DTI) prediction, which aims at predicting whether a drug will be bounded to a target, have received wide attention recently, with the goal to automate and accelerate the costly process of drug design. Most of the…

Biomolecules · Quantitative Biology 2023-06-27 Shengming Zhang , Yizhou Sun

Finetuning a Large Language Model (LLM) is crucial for generating results towards specific objectives. This research delves into the realm of drug optimization and introduce a novel reinforcement learning algorithm to finetune a drug…

Machine Learning · Computer Science 2025-02-12 Xuefeng Liu , Songhao Jiang , Siyu Chen , Zhuoran Yang , Yuxin Chen , Ian Foster , Rick Stevens

Recent studies suggest that drug-drug interaction (DDI) prediction via computational approaches has significant importance for understanding the functions and co-prescriptions of multiple drugs. However, the existing silico DDI prediction…

Molecular Networks · Quantitative Biology 2024-08-29 Changjian Zhou , Xin Zhang , Jiafeng Li , Jia Song , Wensheng Xiang

Drug-drug interactions (DDIs) are a major concern in clinical practice, as they can lead to reduced therapeutic efficacy or severe adverse effects. Traditional computational approaches often struggle to capture the complex relationships…

Machine Learning · Computer Science 2025-08-27 Hongbo Liu , Siyi Li , Zheng Yu

Traditional psychological models of belief revision focus on face-to-face interactions, but with the rise of social media, more effective models are needed to capture belief revision at scale, in this rich text-based online discourse. Here,…

Computation and Language · Computer Science 2025-12-01 Gia Bao Hoang , Keith J Ransom , Rachel Stephens , Carolyn Semmler , Nicolas Fay , Lewis Mitchell

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

This paper introduces a new hybrid framework that combines Reinforcement Learning (RL) and Large Language Models (LLMs) to improve robotic manipulation tasks. By utilizing RL for accurate low-level control and LLMs for high level task…

Robotics · Computer Science 2026-04-01 Md Saad , Sajjad Hussain , Mohd Suhaib

Pre-trained Language Models (PLMs) exhibit good accuracy and generalization ability across various tasks using self-supervision, but their large size results in high inference latency. Early Exit (EE) strategies handle the issue by allowing…

Computation and Language · Computer Science 2024-10-08 Divya Jyoti Bajpai , Manjesh Kumar Hanawal

Drug recommendation is an essential task in machine learning-based clinical decision support systems. However, the risk of drug-drug interactions (DDI) between co-prescribed medications remains a significant challenge. Previous studies have…

Machine Learning · Computer Science 2025-10-10 Chongmyung Kwon , Yujin Kim , Seoeun Park , Yunji Lee , Charmgil Hong

The success of expanded context windows in Large Language Models (LLMs) has driven increased use of broader context in retrieval-augmented generation. We investigate the use of LLMs for retrieval augmented question answering. While longer…

Computation and Language · Computer Science 2026-01-01 Dingmin Wang , Ji Ma , Shankar Kumar

Off-the-shelf biomedical embeddings obtained from the recently released various pre-trained language models (such as BERT, XLNET) have demonstrated state-of-the-art results (in terms of accuracy) for the various natural language…

Computation and Language · Computer Science 2020-12-22 Ishani Mondal

The ability to predict drug overdose risk from a patient's medical records is crucial for timely intervention and prevention. Traditional machine learning models have shown promise in analyzing longitudinal medical records for this task.…

Artificial Intelligence · Computer Science 2025-04-17 Md Sultan Al Nahian , Chris Delcher , Daniel Harris , Peter Akpunonu , Ramakanth Kavuluru

Large language models (LLMs) demonstrate remarkable text comprehension and generation capabilities but often lack the ability to utilize up-to-date or domain-specific knowledge not included in their training data. To address this gap, we…

Computation and Language · Computer Science 2025-09-26 Bo Zhang , Hui Ma , Dailin Li , Jian Ding , Jian Wang , Bo Xu , HongFei Lin

Pre-trained language models (PLMs) have achieved remarkable success on various natural language understanding tasks. Simple fine-tuning of PLMs, on the other hand, might be suboptimal for domain-specific tasks because they cannot possibly…

Computation and Language · Computer Science 2022-08-05 Minki Kang , Jinheon Baek , Sung Ju Hwang

Large Language Models (LLMs) often struggle with dynamically changing knowledge and handling unknown static information. Retrieval-Augmented Generation (RAG) is employed to tackle these challenges and has a significant impact on improving…

Computation and Language · Computer Science 2025-09-18 Zhen Zhang , Xinyu Wang , Yong Jiang , Zile Qiao , Zhuo Chen , Guangyu Li , Feiteng Mu , Mengting Hu , Pengjun Xie , Fei Huang

Large language models (LLMs) have been increasingly applied to tasks in language understanding and interactive decision-making, with their impressive performance largely attributed to the extensive domain knowledge embedded within them.…

Artificial Intelligence · Computer Science 2024-10-16 Zhiyuan Sun , Haochen Shi , Marc-Alexandre Côté , Glen Berseth , Xingdi Yuan , Bang Liu

Large Language Models (LLMs) have achieved exceptional capabilities in open generation across various domains, yet they encounter difficulties with tasks that require intensive knowledge. To address these challenges, methods for integrating…

Computation and Language · Computer Science 2024-12-17 Fali Wang , Runxue Bao , Suhang Wang , Wenchao Yu , Yanchi Liu , Wei Cheng , Haifeng Chen

Concomitant administration of drugs can cause drug-drug interactions (DDIs). Some drug combinations are beneficial, but other ones may cause negative effects which are previously unrecorded. Previous works on DDI prediction usually rely on…

Artificial Intelligence · Computer Science 2022-08-26 Xinyu Zhu , Yongliang Shen , Weiming Lu

Knowledge-enhanced language models (KELMs) have emerged as promising tools to bridge the gap between large-scale language models and domain-specific knowledge. KELMs can achieve higher factual accuracy and mitigate hallucinations by…

Computation and Language · Computer Science 2024-11-26 Alexander Fichtl , Juraj Vladika , Georg Groh