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Super-resolution imaging using sub-diffraction field localization by micron sized transparent beads (microspheres) was recently demonstrated [1]. Practical applications in microscopy require control over the positioning of the microspheres.…

Optics · Physics 2013-12-25 Leonid A. Krivitsky , Jia Jun Wang , Zengbo Wang , Boris Lukiyanchuk

Recent work has demonstrated that large-scale, multi-animal models are powerful tools for characterizing the relationship between neural activity and behavior. Current large-scale approaches, however, focus exclusively on either predicting…

Identifying individual animals is crucial for many biological investigations. In response to some of the limitations of current identification methods, new automated computer vision approaches have emerged with strong performance. Here, we…

Computer Vision and Pattern Recognition · Computer Science 2021-12-22 Maxime Vidal , Nathan Wolf , Beth Rosenberg , Bradley P. Harris , Alexander Mathis

We demonstrate that a deep neural network can significantly improve optical microscopy, enhancing its spatial resolution over a large field-of-view and depth-of-field. After its training, the only input to this network is an image acquired…

Machine Learning · Computer Science 2017-11-21 Yair Rivenson , Zoltan Gorocs , Harun Gunaydin , Yibo Zhang , Hongda Wang , Aydogan Ozcan

The increasing rise in machine learning and deep learning applications is requiring ever more computational resources to successfully meet the growing demands of an always-connected, automated world. Neuromorphic technologies based on…

Neural and Evolutionary Computing · Computer Science 2020-07-14 Philippe Reiter , Geet Rose Jose , Spyridon Bizmpikis , Ionela-Ancuţa Cîrjilă

Even during fixation the human eye is constantly in low amplitude motion, jittering over small angles in random directions at up to 100Hz. This motion results in all features of the image on the retina constantly traversing a number of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 David W Arathorn , Josephine C. D'Angelo , Austin Roorda

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

Neural networks have enabled applications in artificial intelligence through machine learning, and neuromorphic computing. Software implementations of neural networks on conventional computers that have separate memory and processor (and…

Spiking neural networks (SNNs) have captured apparent interest over the recent years, stemming from neuroscience and reaching the field of artificial intelligence. However, due to their nature SNNs remain far behind in achieving the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-22 Katerina Maria Oikonomou , Vasiliki Balaska , Konstantinos A. Tsintotas , Christos N. Mavridis , Ioannis Kansizoglou , Antonios Gasteratos

Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül

Since their invention in the 1980s [1], optical tweezers have found a wide range of applications, from biophotonics and mechanobiology to microscopy and optomechanics [2, 3, 4, 5]. Simulations of the motion of microscopic particles held by…

Exploring the developing brain is a major issue in understanding what enables children to acquire amazing abilities, and how early disruptions can lead to a wide range of neurodevelopmental disorders. MRI plays a key role here by providing…

Neurons and Cognition · Quantitative Biology 2024-01-01 Jessica Dubois

Animal brains flexibly and efficiently achieve many behavioral tasks with a single neural network. A core goal in modern neuroscience is to map the mechanisms of the brain's flexibility onto the dynamics underlying neural populations.…

Neurons and Cognition · Quantitative Biology 2026-03-12 Anirudh Jamkhandi , Ali Korojy , Olivier Codol , Guillaume Lajoie , Matthew G. Perich

There has been a consistent growth in research involving imaging of microvasculature over the past few decades. By 2008, publications mentioning the microcirculation had grown more than 2000 per annum. Many techniques have been demonstrated…

Medical Physics · Physics 2019-07-04 Cerine Lal , Martin J Leahy

Magnetoencephalography (MEG) enables the study of brain activity by recording the magnetic fields generated by neural currents and has become an important technique for neuroscientists in research and clinical settings. Unlike the…

The human brain contains approximately $10^9$ neurons, each with approximately $10^3$ connections, synapses, with other neurons. Most sensory, cognitive and motor functions of our brains depend on the interaction of a large population of…

Neurons and Cognition · Quantitative Biology 2021-08-30 Bülent Karasözen

An optical microscope is probably the most intuitive, simple and commonly used instrument to observe objects and discuss behaviors through images. Although the idea of imaging electrochemical processes operando by optical microscopy was…

Optics · Physics 2022-11-16 Jean-François Lemineur , Hui Wang , Wei Wang , Frédéric Kanoufi

In this paper, we focus on identifying differentially activated brain regions using a light sheet fluorescence microscopy - a recently developed technique for whole-brain imaging. Most existing statistical methods solve this problem by…

Though performed almost effortlessly by humans, segmenting 2D gray-scale or color images into respective regions of interest (e.g.~background, objects, or portions of objects) constitutes one of the greatest challenges in science and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Alexandre Benatti , Luciano da F. Costa

Naturalistic recordings capture audio in real-world environments where participants behave naturally without interference from researchers or experimental protocols. Naturalistic long-form recordings extend this concept by capturing…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-24 Jialu Li , Marvin Lavechin , Xulin Fan , Nancy L. McElwain , Alejandrina Cristia , Paola Garcia-Perera , Mark Hasegawa-Johnson