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Configuring LLM-based agent systems involves choosing workflows, tools, token budgets, and prompts from a large combinatorial design space, and is typically handled today by fixed templates or hand-tuned heuristics that apply the same…

Artificial Intelligence · Computer Science 2026-05-22 Aditya Taparia , Som Sagar , Ransalu Senanayake

Recent reasoning Large Language Models (LLMs) demonstrate remarkable problem-solving abilities but often generate long thinking traces whose utility is unclear. Our work aims to improve their efficiency, enabling them to reach high…

Computation and Language · Computer Science 2026-05-11 Xiang Liu , Xuming Hu , Xiaowen Chu , Eunsol Choi

We present RAGentA, a multi-agent retrieval-augmented generation (RAG) framework for attributed question answering (QA) with large language models (LLMs). With the goal of trustworthy answer generation, RAGentA focuses on optimizing answer…

Information Retrieval · Computer Science 2025-09-03 Ines Besrour , Jingbo He , Tobias Schreieder , Michael Färber

Recent research on Reasoning of Large Language Models (LLMs) has sought to further enhance their performance by integrating meta-thinking -- enabling models to monitor, evaluate, and control their reasoning processes for more adaptive and…

Artificial Intelligence · Computer Science 2025-05-28 Ziyu Wan , Yunxiang Li , Xiaoyu Wen , Yan Song , Hanjing Wang , Linyi Yang , Mark Schmidt , Jun Wang , Weinan Zhang , Shuyue Hu , Ying Wen

Existing change detection methods often lack the versatility to handle diverse real-world queries and the intelligence for comprehensive analysis. This paper presents a general agent framework, integrating Large Language Models (LLM) with…

Artificial Intelligence · Computer Science 2026-01-08 Zixuan Xiao , Jun Ma

Retrosynthesis is essential for designing synthetic pathways for complex molecules and can be revolutionized by AI to automate and accelerate chemical synthesis planning for drug discovery and materials science. Here, we propose a…

Chemical Physics · Physics 2024-12-02 Seongeun Yun , Won Bo Lee

Agentic retrieval-augmented reasoning pipelines are increasingly used to structure how large language models (LLMs) incorporate external evidence in clinical decision support. These systems iteratively retrieve curated domain knowledge and…

Alloy discovery is constrained by vast compositional spaces, competing objectives, and prohibitive experimental costs. Although simulations and machine learning have each accelerated parts of this process, unifying scientific knowledge,…

Conventional AI-driven AMS design automation algorithms remain constrained by their reliance on high-quality datasets to capture underlying circuit behavior, coupled with poor transferability across architectures, and a lack of adaptive…

Artificial Intelligence · Computer Science 2026-03-30 Souradip Poddar , Chia-Tung Ho , Ziming Wei , Weidong Cao , Haoxing Ren , David Z. Pan

The convergence of artificial intelligence and materials science presents a transformative opportunity, but achieving true acceleration in discovery requires moving beyond task-isolated, fine-tuned models toward agentic systems that plan,…

Reliable decision support in nuclear engineering requires traceable, domain-grounded knowledge retrieval, yet safety and risk analysis workflows remain hampered by fragmented documentation and hallucination when use pre-trained large…

Information Retrieval · Computer Science 2026-04-28 Zavier Ndum Ndum , Jian Tao , John Ford , Mansung Yim , Yang Liu

Standard reinforcement learning (RL) for large language model (LLM) agents typically optimizes extrinsic rewards, prioritizing isolated task completion over continual adaptation. Consequently, agents often converge to suboptimal policies…

Artificial Intelligence · Computer Science 2026-03-31 Xiaoying Zhang , Zichen Liu , Yipeng Zhang , Xia Hu , Wenqi Shao

Drug discovery is a complex, multi-step pipeline that remains heavily dependent on manual, experience-driven operations; meanwhile, existing customized artificial intelligence tools are fragmented across web applications, desktop software,…

Biomolecules · Quantitative Biology 2026-03-03 Qihua Pan , Dong Xu , Qianwei Yang , Jenna Xinyi Yao , Sisi Yuan , Zexuan Zhu , Jianqiang Li , Junkai Ji

When an LLM-based agent improves on a task, is the gain from the model itself or from the reasoning paradigm wrapped around it? We study this question by comparing six inference-time paradigms, namely Direct, CoT, ReAct, Plan-Execute,…

Automated alpha discovery is difficult because the search space of formulaic factors is combinatorial, the signal-to-noise ratio in daily equity data is low, and unconstrained program generation is operationally unsafe. We present Hubble,…

Artificial Intelligence · Computer Science 2026-04-15 Runze Shi , Shengyu Yan , Yuecheng Cai , Chengxi Lv

Recent progress in Large Language Models (LLMs) has drawn attention to their potential for accelerating drug discovery. However, a central problem remains: translating theoretical ideas into robust implementations in the highly specialized…

Machine Learning · Computer Science 2025-03-06 Sizhe Liu , Yizhou Lu , Siyu Chen , Xiyang Hu , Jieyu Zhao , Yingzhou Lu , Yue Zhao

Searches for signatures of new physics in top anti-top events at the LHC require efficient reconstruction of top quarks with a broad range of transverse momenta. Three new reconstruction schemes are developed to deal with the large variety…

High Energy Physics - Experiment · Physics 2019-08-13 Bertrand Chapleau

Structural High Entropy Alloys (HEAs) are crucial in advancing technology across various sectors, including aerospace, automotive, and defense industries. However, the scarcity of integrated chemistry, process, structure, and property data…

Memory mechanism is a core component of LLM-based agents, enabling reasoning and knowledge discovery over long-horizon contexts. Existing agent memory systems are typically designed within isolated paradigms (e.g., explicit, parametric, or…

Artificial Intelligence · Computer Science 2026-02-10 Xin Zhang , Kailai Yang , Chenyue Li , Hao Li , Qiyu Wei , Jun'ichi Tsujii , Sophia Ananiadou

The evolution of Large Language Model (LLM) agents towards System~2 reasoning, characterized by deliberative, high-precision problem-solving, requires maintaining rigorous logical integrity over extended horizons. However, prevalent memory…

Artificial Intelligence · Computer Science 2026-05-15 Kaixiang Wang , Yidan Lin , Jiong Lou , Zhaojiacheng Zhou , Bunyod Suvonov , Jie Li
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