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Large Language Models (LLMs) have demonstrated impressive capabilities, yet their deployment in high-stakes domains is hindered by inherent limitations in trustworthiness, including hallucinations, instability, and a lack of transparency.…

Computation and Language · Computer Science 2025-10-21 David Peer , Sebastian Stabinger

Large language models (LLMs) have demonstrated significant reasoning capabilities in scientific discovery but struggle to bridge the gap to physical execution in wet-labs. In these irreversible environments, probabilistic hallucinations are…

Artificial Intelligence · Computer Science 2026-05-19 Yuyang Liu , Jingya Wang , Liuzhenghao Lv , Yonghong Tian

Current Large Language Models (LLMs) exhibit a critical modal disconnect: they possess vast semantic knowledge but lack the procedural grounding to respect the immutable laws of the physical world. Consequently, while these agents…

Computation and Language · Computer Science 2026-01-21 Baochang Ren , Yunzhi Yao , Rui Sun , Shuofei Qiao , Ningyu Zhang , Huajun Chen

Explaining observed phenomena through symbolic, interpretable formulas is a fundamental goal of science. Recently, large language models (LLMs) have emerged as promising tools for symbolic equation discovery, owing to their broad domain…

Artificial Intelligence · Computer Science 2026-02-26 Jianke Yang , Ohm Venkatachalam , Mohammad Kianezhad , Sharvaree Vadgama , Rose Yu

Large Language Models (LLMs) have emerged as powerful tools for accelerating scientific discovery, yet their static knowledge and hallucination issues hinder autonomous research applications. Recent advances integrate LLMs into agentic…

Artificial Intelligence · Computer Science 2025-12-23 Zeyu Xia , Jinzhe Ma , Congjie Zheng , Shufei Zhang , Yuqiang Li , Hang Su , P. Hu , Changshui Zhang , Xingao Gong , Wanli Ouyang , Lei Bai , Dongzhan Zhou , Mao Su

The advancement in generative AI could be boosted with more accessible mathematics. Beyond human-AI chat, large language models (LLMs) are emerging in programming, algorithm discovery, and theorem proving, yet their genomics application is…

Other Quantitative Biology · Quantitative Biology 2023-07-07 Melanie Swan , Takashi Kido , Eric Roland , Renato P. dos Santos

As LLM-based agents increasingly operate in high-stakes domains with real-world consequences, ensuring their behavioral safety becomes paramount. The dominant oversight paradigm, LLM-as-a-Judge, faces a fundamental dilemma: how can…

Artificial Intelligence · Computer Science 2026-02-13 Jiayi Zhou , Yang Sheng , Hantao Lou , Yaodong Yang , Jie Fu

Large Language Models (LLMs) can generate Computer-Aided Design (CAD), yet lack physical comprehension required for reliable engineering design. Instead of attempting to implicitly learn physical laws from data, we propose a Hybrid…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Elias Berger , Muhammad Usama , Jan Mehlstäubl , Bernhard Saske , Kristin Paetzold-Byhain

Machine-learning methods are gradually being adopted in a wide variety of social, economic, and scientific contexts, yet they are notorious for struggling with exact mathematics. A typical example is computer algebra, which includes tasks…

Machine Learning · Computer Science 2024-11-06 Lennart Dabelow , Masahito Ueda

Artificial intelligence is reshaping scientific exploration, but most methods automate procedural tasks without engaging in scientific reasoning, limiting autonomy in discovery. We introduce Materials Agents for Simulation and Theory in…

Recent advancements have highlighted that Large Language Models (LLMs) are prone to hallucinations when solving complex reasoning problems, leading to erroneous results. To tackle this issue, researchers incorporate Knowledge Graphs (KGs)…

Artificial Intelligence · Computer Science 2025-02-19 Ben Liu , Jihai Zhang , Fangquan Lin , Cheng Yang , Min Peng , Wotao Yin

LLM-based agent architectures systematically conflate information transport mechanisms with epistemic justification mechanisms. We formalize this class of architectural failures as semantic laundering: a pattern where propositions with…

Artificial Intelligence · Computer Science 2026-01-14 Oleg Romanchuk , Roman Bondar

Developing constitutive models that capture how materials deform under load traditionally requires years of specialized expertise in continuum mechanics, machine learning, and scientific programming. Large language models (LLMs) have…

Machine Learning · Computer Science 2026-05-25 Marius Tacke , Matthias Busch , Kian Abdolazizi , Jonas Eichinger , Kevin Linka , Roland Aydin , Christian Cyron

Discovering explicit physical laws has traditionally depended on human intuition and domain expertise. Recent advances in artificial intelligence, particularly large language models (LLMs), offer a new route to accelerate this process by…

Materials Science · Physics 2026-01-30 Bo Hu , Siyu Liu , Beilin Ye , Yun Hao , Yanhui Liu , Yang Lu , Ju Li , David J. Srolovitz , Tongqi Wen

The deployment of autonomous agents for Computational Fluid Dynamics (CFD), is critically limited by the probabilistic nature of Large Language Models (LLMs), which struggle to enforce the strict conservation laws and numerical stability…

Artificial Intelligence · Computer Science 2026-02-13 E Fan , Lisong Shi , Zhengtong Li , Chih-yung Wen

Large language model (LLM)-based multi-agent systems enable expressive agent reasoning but are expensive to scale and poorly calibrated for timestep-aligned state-transition simulation, while classical agent-based models (ABMs) offer…

Multiagent Systems · Computer Science 2026-02-10 Kavana Venkatesh , Yinhan He , Jundong Li , Jiaming Cui

Large language models (LLMs) are a promising venue for natural language understanding and generation. However, current LLMs are far from reliable: they are prone to generating non-factual information and, more crucially, to contradicting…

Computation and Language · Computer Science 2024-09-24 Diego Calanzone , Stefano Teso , Antonio Vergari

The advancement of data-driven materials science is currently constrained by a fundamental bottleneck: the vast majority of historical experimental data remains locked within the unstructured text and rasterized figures of legacy scientific…

Databases · Computer Science 2026-02-04 Yue Wu , Tianhao Su , Shunbo Hu , Deng Pan

Artificial intelligence has demonstrated remarkable capability in predicting scientific properties, yet scientific discovery remains an inherently physical, long-horizon pursuit governed by experimental cycles. Most current computational…

Artificial Intelligence · Computer Science 2026-03-23 Xiang Zhuang , Chenyi Zhou , Kehua Feng , Zhihui Zhu , Yunfan Gao , Yijie Zhong , Yichi Zhang , Junjie Huang , Keyan Ding , Lei Bai , Haofen Wang , Qiang Zhang , Huajun Chen

We study mathematical discovery through the lens of neurosymbolic reasoning, where an AI agent powered by a large language model (LLM), coupled with symbolic computation tools, and human strategic direction, jointly produced a new result in…

Artificial Intelligence · Computer Science 2026-03-10 Hai Xia , Carla P. Gomes , Bart Selman , Stefan Szeider
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