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It is well-known that deep neural networks (DNNs) have shown remarkable success in many fields. However, when adding an imperceptible magnitude perturbation on the model input, the model performance might get rapid decrease. To address this…

Machine Learning · Computer Science 2022-01-04 Hao Yang , Min Wang , Zhengfei Yu , Yun Zhou

The location, timing, and abundance of gene expression (both mRNA and proteins) within a tissue define the molecular mechanisms of cell functions. Recent technology breakthroughs in spatial molecular profiling, including imaging-based…

Applications · Statistics 2020-12-10 Qiwei Li , Minzhe Zhang , Yang Xie , Guanghua Xiao

Simultaneous modeling of the spatio-temporal variation patterns of brain functional network from 4D fMRI data has been an important yet challenging problem for the field of cognitive neuroscience and medical image analysis. Inspired by the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-24 Yu Zhao , Xiang Li , Wei Zhang , Shijie Zhao , Milad Makkie , Mo Zhang , Quanzheng Li , Tianming Liu

Fast and cheaper next generation sequencing technologies will generate unprecedentedly massive and highly-dimensional genomic and epigenomic variation data. In the near future, a routine part of medical record will include the sequenced…

Genomics · Quantitative Biology 2013-01-17 Momiao Xiong , Long Ma

Spatial Transcriptomics (ST) technologies provide biologists with rich insights into single-cell biology by preserving spatial context of cells. Building foundational models for ST can significantly enhance the analysis of vast and complex…

Genomics · Quantitative Biology 2025-07-24 Suyuan Zhao , Yizhen Luo , Ganbo Yang , Yan Zhong , Hao Zhou , Zaiqing Nie

We propose a novel distributed inference algorithm for continuous graphical models, by extending Stein variational gradient descent (SVGD) to leverage the Markov dependency structure of the distribution of interest. Our approach combines…

Machine Learning · Statistics 2018-06-11 Dilin Wang , Zhe Zeng , Qiang Liu

Remote sensing images captured by different platforms exhibit significant disparities in spatial resolution. Large scale factor super-resolution (SR) algorithms are vital for maximizing the utilization of low-resolution (LR) satellite data…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Ce Wang , Wanjie Sun

Accurate delineation of tumor-adjacent functional brain regions is essential for planning function-preserving neurosurgery. Functional magnetic resonance imaging (fMRI) is increasingly used for presurgical counseling and planning. When…

Methodology · Statistics 2023-12-22 Yifei Hu , Xinge Jessie Jeng

In this study, we propose a method Distributionally Robust Safe Screening (DRSS), for identifying unnecessary samples and features within a DR covariate shift setting. This method effectively combines DR learning, a paradigm aimed at…

Stein variational gradient descent (SVGD) is a kernel-based and non-parametric particle method for sampling from a target distribution, such as in Bayesian inference and other machine learning tasks. Different from other particle methods,…

Optimization and Control · Mathematics 2025-10-02 Viktor Stein , Wuchen Li

Multiple-proposal MCMC algorithms have recently gained attention for their potential to improve performance, especially through parallel implementation on modern hardware. We introduce Stereographic Multiple-Try Metropolis (SMTM), a novel…

Computation · Statistics 2026-05-01 Zhihao Wang , Jun Yang

The problem of selecting a handful of truly relevant variables in supervised machine learning algorithms is a challenging problem in terms of untestable assumptions that must hold and unavailability of theoretical assurances that selection…

Methodology · Statistics 2023-11-10 Mehdi Rostami , Olli Saarela

Significant progress has been witnessed in learning-based Multi-view Stereo (MVS) under supervised and unsupervised settings. To combine their respective merits in accuracy and completeness, meantime reducing the demand for expensive…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Hongbin Xu , Weitao Chen , Yang Liu , Zhipeng Zhou , Haihong Xiao , Baigui Sun , Xuansong Xie , Wenxiong Kang

Support Vector Machine (SVM) is a robust machine learning algorithm with broad applications in classification, regression, and outlier detection. SVM requires tuning the regularization parameter (RP) which controls the model capacity and…

Machine Learning · Statistics 2023-05-18 Mahdi Shamsi , Soosan Beheshti

Structural variants compose the majority of human genetic variation, but are difficult to assess using current genomic sequencing technologies. Optical mapping technologies, which measure the size of chromosomal fragments between labeled…

Quantitative Methods · Quantitative Biology 2019-10-10 Weiwei Li , Jan Hannig , Corbin Jones

Vision Transformers (ViTs) have achieved remarkable success in computer vision tasks. However, their potential in rotation-sensitive scenarios has not been fully explored, and this limitation may be inherently attributed to the lack of…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Hongtian Yu , Yunjie Tian , Qixiang Ye , Yunfan Liu

The problem of large-scale spatial multiple testing is often encountered in various scientific research fields, where the signals are usually enriched on some regions while sparse on others. To integrate spatial structure information from…

Methodology · Statistics 2023-09-28 Pengfei Wang , Pengyu Yan , Canhui Li

The trimming scheme with a prefixed cutoff portion is known as a method of improving the robustness of statistical models such as multivariate Gaussian mixture models (MG- MMs) in small scale tests by alleviating the impacts of outliers.…

Computation and Language · Computer Science 2014-05-20 Dalei Wu , Haiqing Wu

Support vector regression (SVR) is one of the most popular machine learning algorithms aiming to generate the optimal regression curve through maximizing the minimal margin of selected training samples, i.e., support vectors. Recent…

Machine Learning · Computer Science 2019-05-07 Gaoyang Li , Jinyu Yang , Chunguo Wu , Qin Ma

Cellular identity and function are linked to both their intrinsic genomic makeup and extrinsic spatial context within the tissue microenvironment. Spatial transcriptomics (ST) offers an unprecedented opportunity to study this, providing in…

Machine Learning · Computer Science 2026-02-16 Rui Yan , Xiaohan Xing , Xun Wang , Zixia Zhou , Md Tauhidul Islam , Lei Xing