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To increase the trustworthiness of deep neural networks, it is critical to improve the understanding of how they make decisions. This paper introduces a novel unsupervised concept-based model for image classification, named Learnable…

Machine Learning · Computer Science 2025-06-04 Francesco De Santis , Philippe Bich , Gabriele Ciravegna , Pietro Barbiero , Danilo Giordano , Tania Cerquitelli

Reasoning is a critical frontier for advancing medical image analysis, where transparency and trustworthiness play a central role in both clinician trust and regulatory approval. Although Medical Visual Language Models (VLMs) show promise…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Jiazhen Pan , Che Liu , Junde Wu , Fenglin Liu , Jiayuan Zhu , Hongwei Bran Li , Chen Chen , Cheng Ouyang , Daniel Rueckert

Appendicitis is among the most frequent reasons for pediatric abdominal surgeries. Previous decision support systems for appendicitis have focused on clinical, laboratory, scoring, and computed tomography data and have ignored abdominal…

Recently, interpretable machine learning has re-explored concept bottleneck models (CBM). An advantage of this model class is the user's ability to intervene on predicted concept values, affecting the downstream output. In this work, we…

Machine Learning · Computer Science 2024-10-29 Sonia Laguna , Ričards Marcinkevičs , Moritz Vandenhirtz , Julia E. Vogt

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

The rapid advancements in Vision Language Models (VLMs) have prompted the development of multi-modal medical assistant systems. Despite this progress, current models still have inherent probabilistic uncertainties, often producing erroneous…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Xiao Liang , Di Wang , Zhicheng Jiao , Ronghan Li , Pengfei Yang , Quan Wang , Tat-Seng Chua

With growing demand for interpretability in deep learning, especially in high stakes domains, Concept Bottleneck Models (CBMs) address this by inserting human understandable concepts into the prediction pipeline, but they are generally…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Jiakai Lin , Jinchang Zhang , Guoyu Lu

Interpreting and explaining the behavior of deep neural networks is critical for many tasks. Explainable AI provides a way to address this challenge, mostly by providing per-pixel relevance to the decision. Yet, interpreting such…

Computer Vision and Pattern Recognition · Computer Science 2023-04-21 Bowen Wang , Liangzhi Li , Yuta Nakashima , Hajime Nagahara

Accurate and interpretable prediction of estimated glomerular filtration rate (eGFR) is essential for managing chronic kidney disease (CKD) and supporting clinical decisions. Recent advances in Large Multimodal Models (LMMs) have shown…

Machine Learning · Computer Science 2025-07-31 Peng-Yi Wu , Pei-Cing Huang , Ting-Yu Chen , Chantung Ku , Ming-Yen Lin , Yihuang Kang

Despite significant advancements, current large language models (LLMs) and vision-language models (LVLMs) continue to struggle with complex, multi-step, cross-modal common sense reasoning tasks, often exhibiting a lack of "deliberative…

Computation and Language · Computer Science 2025-08-06 Wenjie Luo , Ruocheng Li , Shanshan Zhu , Julian Perry

Concept Bottleneck Models (CBNMs) are deep learning models that provide interpretability by enforcing a bottleneck layer where predictions are based exclusively on human-understandable concepts. However, this constraint also restricts…

Machine Learning · Computer Science 2025-10-17 David Debot , Giuseppe Marra

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Juntao Jiang , Jiangning Zhang , Yali Bi , Jinsheng Bai , Weixuan Liu , Weiwei Jin , Zhucun Xue , Yong Liu , Xiaobin Hu , Shuicheng Yan

Pretrained language models (PLMs) have made significant strides in various natural language processing tasks. However, the lack of interpretability due to their ``black-box'' nature poses challenges for responsible implementation. Although…

Computation and Language · Computer Science 2023-11-10 Zhen Tan , Lu Cheng , Song Wang , Yuan Bo , Jundong Li , Huan Liu

Concept Bottleneck Models (CBMs) aim to deliver interpretable and interventionable predictions by bridging features and labels with human-understandable concepts. While recent CBMs show promising potential, they suffer from information…

Machine Learning · Computer Science 2024-02-12 Ao Sun , Yuanyuan Yuan , Pingchuan Ma , Shuai Wang

Early detection of melanoma is crucial for preventing severe complications and increasing the chances of successful treatment. Existing deep learning approaches for melanoma skin lesion diagnosis are deemed black-box models, as they omit…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Cristiano Patrício , João C. Neves , Luís F. Teixeira

Medical Vision-Language Models (Med-VLMs) have demonstrated remarkable performance across diverse medical imaging tasks by leveraging large-scale image-text pretraining. However, their confidence calibration is largely unexplored, and so…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Abhishek Basu , Fahad Shamshad , Ashshak Sharifdeen , Karthik Nandakumar , Muhammad Haris Khan

Interpretation is critical for disease diagnosis, but existing models struggle to balance predictive accuracy with human-understandable rationales. While large language models (LLMs) offer strong reasoning abilities, their clinical use is…

Computation and Language · Computer Science 2025-07-15 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Yida Xu , Yunya Song , Xian Yang

Concept Bottleneck Models (CBMs) are interpretable models that predict the target variable through high-level human-understandable concepts, allowing users to intervene on mispredicted concepts to adjust the final output. While recent work…

Machine Learning · Computer Science 2026-03-17 Wiktor Jan Hoffmann , Sonia Laguna , Moritz Vandenhirtz , Emanuele Palumbo , Julia E. Vogt

Concept-based models aim to explain model decisions with human-understandable concepts. However, most existing approaches treat concepts as numerical attributes, without providing complementary visual explanations that could localize the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Cristiano Patrício , Luís F. Teixeira , João C. Neves

Cataract surgery remains one of the most widely performed and effective procedures for vision restoration. Effective surgical planning requires integrating diverse clinical examinations for patient assessment, intraocular lens (IOL)…

Multiagent Systems · Computer Science 2025-08-28 Yang Meng , Zewen Pan , Yandi Lu , Ruobing Huang , Yanfeng Liao , Jiarui Yang