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Large Language Models (LLMs) have attained human-level accuracy on medical question-answer (QA) benchmarks. However, their limitations in navigating open-ended clinical scenarios have recently been shown, raising concerns about the…

Computation and Language · Computer Science 2025-11-13 Jonathan Kim , Anna Podlasek , Kie Shidara , Feng Liu , Ahmed Alaa , Danilo Bernardo

Large language models (LLMs) have shown great potential in the medical domain. However, existing models still fall short when faced with complex medical diagnosis task in the real world. This is mainly because they lack sufficient reasoning…

Artificial Intelligence · Computer Science 2025-08-06 Qi Peng , Jialin Cui , Jiayuan Xie , Yi Cai , Qing Li

Large Language Model (LLM)-based agents exhibit systemic failures in compositional generalization, limiting their robustness in interactive environments. This work introduces AGEL-Comp, a neuro-symbolic AI agent architecture designed to…

Artificial Intelligence · Computer Science 2026-04-30 Mahnoor Shahid , Hannes Rothe

Learning-based signal processing systems increasingly support high-stakes medical decisions using heterogeneous biomedical signals, including medical images, physiological time series, and clinical records. Despite strong predictive…

Signal Processing · Electrical Eng. & Systems 2026-03-02 Surajit Das , Maxine Tan

Multimodal Large Language Models (MLLMs) in healthcare suffer from severe confirmation bias, often hallucinating visual details to support initial, potentially erroneous diagnostic hypotheses. Existing Chain-of-Thought (CoT) approaches lack…

Computation and Language · Computer Science 2026-04-14 Zhixiang Lu , Jionglong Su

Large language models (LLMs) hold transformative potential for medical decision support yet their application in psychiatry remains constrained by hallucinations and superficial reasoning. This limitation is particularly acute in…

Uncertainty quantification is necessary for developers, physicians, and regulatory agencies to build trust in machine learning predictors and improve patient care. Beyond measuring uncertainty, it is crucial to express it in clinically…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Jacopo Teneggi , J Webster Stayman , Jeremias Sulam

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Juntao Jiang , Jiangning Zhang , Yali Bi , Jinsheng Bai , Weixuan Liu , Weiwei Jin , Zhucun Xue , Yong Liu , Xiaobin Hu , Shuicheng Yan

Large language models (LLMs) have achieved remarkable capabilities, yet methods to verify which model components are truly necessary for language function remain limited. Current interpretability approaches rely on internal metrics and lack…

Comic understanding presents a significant challenge for Multimodal Large Language Models (MLLMs), as the intended meaning of a comic often emerges from the joint interpretation of visual, textual, and social cues. This naturally motivates…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Chengcheng Feng , Haojie Yin , Yucheng Jin , Kaizhu Huang

To perform effective causal inference in high-dimensional datasets, initiating the process with causal discovery is imperative, wherein a causal graph is generated based on observational data. However, obtaining a complete and accurate…

Machine Learning · Computer Science 2025-04-18 Elahe Khatibi , Mahyar Abbasian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

While the recent Chain-of-Thought (CoT) technique enhances the reasoning ability of large language models (LLMs) with the theory of mind, it might still struggle in handling logical reasoning that relies much on symbolic expressions and…

Computation and Language · Computer Science 2024-06-12 Jundong Xu , Hao Fei , Liangming Pan , Qian Liu , Mong-Li Lee , Wynne Hsu

Clinical practice guidelines (CPGs) provide evidence-based recommendations for patient care; however, integrating them into Artificial Intelligence (AI) remains challenging. Previous approaches, such as rule-based systems, face significant…

Artificial Intelligence · Computer Science 2026-01-08 Ruiqi Deng , Geoffrey Martin , Tony Wang , Gongbo Zhang , Yi Liu , Chunhua Weng , Yanshan Wang , Justin F Rousseau , Yifan Peng

This work compares large language models (LLMs) and neuro-symbolic approaches in solving Raven's progressive matrices (RPM), a visual abstract reasoning test that involves the understanding of mathematical rules such as progression or…

Artificial Intelligence · Computer Science 2024-12-10 Michael Hersche , Giacomo Camposampiero , Roger Wattenhofer , Abu Sebastian , Abbas Rahimi

The deployment of Large Language Models in Medical Question Answering is severely hampered by ambiguous user queries, a significant safety risk that demonstrably reduces answer accuracy in high-stakes healthcare settings. In this paper, we…

Computation and Language · Computer Science 2026-01-27 Yaokun Liu , Yifan Liu , Phoebe Mbuvi , Zelin Li , Ruichen Yao , Gawon Lim , Dong Wang

The lack of transparency in the decision-making processes of deep learning systems presents a significant challenge in modern artificial intelligence (AI), as it impairs users' ability to rely on and verify these systems. To address this…

Artificial Intelligence · Computer Science 2024-11-18 David Debot , Pietro Barbiero , Francesco Giannini , Gabriele Ciravegna , Michelangelo Diligenti , Giuseppe Marra

Intuitive learning is crucial for developing deep conceptual understanding, especially in STEM education, where students often struggle with abstract and interconnected concepts. Automatic question generation has become an effective…

Artificial Intelligence · Computer Science 2026-01-13 Nicholas X. Wang , Neel V. Parpia , Aaryan D. Parikh , Aggelos K. Katsaggelos

Bridging continuous perceptual signals and discrete symbolic reasoning is a fundamental challenge in AI systems that must operate under uncertainty. We present a neuro-symbolic framework that explicitly models and propagates uncertainty…

Artificial Intelligence · Computer Science 2025-11-19 Jiahao Wu , Shengwen Yu

As large language models empower healthcare, intelligent clinical decision support has developed rapidly. Longitudinal electronic health records (EHR) provide essential temporal evidence for accurate clinical diagnosis and analysis.…

Computation and Language · Computer Science 2026-05-15 Zihan Deng , Xiaozhen Zhong , Chuanzhi Xu

Chain-of-Thought (CoT) prompting symbolized a huge improvement of reasoning capabilities of Large Language Models (LLMs). However, scaling up test-time computation yields extensive CoT sequences, introducing severe inference latency and…

Machine Learning · Computer Science 2026-05-12 Tianhao Qian