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Mathematical modeling offers a valuable approach to understanding Alzheimers disease (AD) given its complexity, unknown causes, and lack of effective treatments. Models, once validated, offer a powerful tool to test medical hypotheses that…

Analysis of PDEs · Mathematics 2026-03-20 G. Landi , A. Scaravelli , M. C. Tesi , C. Testa

Fourier Neural Operators (FNOs) excel on tasks using functional data, such as those originating from partial differential equations. Such characteristics render them an effective approach for simulating the time evolution of quantum…

Emerging neuroimaging evidence shows that pathological tau proteins build up along specific brain networks, suggesting that large-scale network architecture plays a key role in the progression of Alzheimer's disease (AD). However, how…

Machine Learning · Computer Science 2025-10-24 Tingting Dan , Xinwei Huang , Jiaqi Ding , Yinggang Zheng , Guorong Wu

Partial differential equations (PDEs) are widely used to model complex physical systems, but solving them efficiently remains a significant challenge. Recently, Transformers have emerged as the preferred architecture for PDEs due to their…

Machine Learning · Computer Science 2026-03-12 Chun-Wun Cheng , Jiahao Huang , Yi Zhang , Guang Yang , Carola-Bibiane Schönlieb , Angelica I. Aviles-Rivero

This paper introduces a novel surrogate modeling framework for aerodynamic applications based on Neural Fields. The proposed approach, MARIO (Modulated Aerodynamic Resolution Invariant Operator), addresses non parametric geometric…

Neural operators excel as deterministic surrogates, but inevitably collapse to the conditional mean when applied to stochastic PDEs, discarding the variance and tail structure upon which uncertainty quantification depends. Recovering this…

Machine Learning · Computer Science 2026-05-18 Kai Hidajat

Classical neural networks are known for their ability to approximate mappings between finite-dimensional spaces, but they fall short in capturing complex operator dynamics across infinite-dimensional function spaces. Neural operators, in…

Neural and Evolutionary Computing · Computer Science 2025-12-11 Bo Zhang

Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly…

Quantitative Methods · Quantitative Biology 2025-04-17 Kerri-Ann Norton , Daniel Bergman , Harsh Vardhan Jain , Trachette Jackson

Agent-based modelling (ABM) is a widespread approach to simulate complex systems. Advancements in computational processing and storage have facilitated the adoption of ABMs across many fields; however, ABMs face challenges that limit their…

Machine Learning · Computer Science 2026-03-06 M Lopes Alves , Joel Dyer , Doyne Farmer , Michael Wooldridge , Anisoara Calinescu

Neural operators (NOs) are designed to learn maps between infinite-dimensional function spaces. We propose a novel reframing of their use. By introducing an auxiliary base-space, any finite-dimensional function can be viewed as an operator…

Machine Learning · Computer Science 2026-05-11 Vasilis Niarchos , Angelos Sirbu , Sokratis Trifinopoulos

We introduce MENO (''Matrix Exponential-based Neural Operator''), a hybrid surrogate modeling framework for efficiently solving stiff systems of ordinary differential equations (ODEs) that exhibit a sparse nonlinear structure. In such…

Computational Physics · Physics 2025-07-22 Ivan Zanardi , Simone Venturi , Marco Panesi

Bayesian optimization (BO), which uses a Gaussian process (GP) as a surrogate to model its objective function, is popular for black-box optimization. However, due to the limitations of GPs, BO underperforms in some problems such as those…

Machine Learning · Computer Science 2022-10-14 Zhongxiang Dai , Yao Shu , Bryan Kian Hsiang Low , Patrick Jaillet

Thrombosis involves processes spanning large-scale fluid flow to sub-cellular events such as platelet activation. Traditional CFD approaches often treat blood as a continuum, which can limit their ability to capture these microscale…

Fluid Dynamics · Physics 2025-03-18 Marco Laudato , Luca Manzari , Khemraj Shukla

We adopt a two-dimensional tensor-network (TN) ansatz to simulate variational quantum algorithms on two-dimensional qubit architectures, demonstrating its capability to accurately simulate deep circuits through the Quantum Approximate…

Quantum Physics · Physics 2026-04-23 Ryo Watanabe , Dries Sels , Joseph Tindall

Transfer learning enhances the training of novel sensory and decision models by employing rich feature representations from large, pre-trained teacher models. Cognitive neuroscience shows that the human brain creates low-dimensional,…

The development of a reliable and robust surrogate model is often constrained by the dimensionality of the problem. For a system with high-dimensional inputs/outputs (I/O), conventional approaches usually use a low-dimensional manifold to…

Image and Video Processing · Electrical Eng. & Systems 2020-10-01 Xihaier Luo , Ahsan Kareem

In scientific machine learning (SciML), a key challenge is learning unknown, evolving physical processes and making predictions across spatio-temporal scales. For example, in real-world manufacturing problems like additive manufacturing,…

Machine Learning · Computer Science 2025-06-16 Vispi Karkaria , Doksoo Lee , Yi-Ping Chen , Yue Yu , Wei Chen

We introduce a novel Multimodal Neural Operator (MNO) architecture designed to learn solution operators for multi-parameter nonlinear boundary value problems (BVPs). Traditional neural operators primarily map either the PDE coefficients or…

Computational Engineering, Finance, and Science · Computer Science 2025-07-17 Vamshi C. Madala , Nithin Govindarajan , Shivkumar Chandrasekaran

Neural-network-based dynamics models learned from observational data have shown strong predictive capabilities for scene dynamics in robotic manipulation tasks. However, their inherent non-linearity presents significant challenges for…

Robotics · Computer Science 2025-03-18 Keyi Shen , Jiangwei Yu , Jose Barreiros , Huan Zhang , Yunzhu Li

This paper focuses on the feasibility of Deep Neural Operator (DeepONet) as a robust surrogate modeling method within the context of digital twin (DT) for nuclear energy systems. Through benchmarking and evaluation, this study showcases the…

Machine Learning · Statistics 2024-04-30 Kazuma Kobayashi , Syed Bahauddin Alam