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Large Genomic Foundation Models have recently achieved remarkable results and in-vivo translation capabilities. However these models quickly grow to over a few Billion of parameters and are expensive to run when compute is limited. To…

Machine Learning · Computer Science 2026-04-13 Rasched Haidari , Sam Martin , Maxime Allard

Deploying large language models (LLMs) is challenging because they are memory inefficient and compute-intensive for practical applications. In reaction, researchers train smaller task-specific models by either finetuning with human labels…

Computation and Language · Computer Science 2023-07-06 Cheng-Yu Hsieh , Chun-Liang Li , Chih-Kuan Yeh , Hootan Nakhost , Yasuhisa Fujii , Alexander Ratner , Ranjay Krishna , Chen-Yu Lee , Tomas Pfister

Knowledge distillation typically involves transferring knowledge from a Large Language Model (LLM) to a Smaller Language Model (SLM). However, in tasks such as text matching, fine-tuned smaller models often yield more effective…

Computation and Language · Computer Science 2025-07-09 Mingzhe Li , Jing Xiang , Qishen Zhang , Kaiyang Wan , Xiuying Chen

Diffusion Language Models (DLMs) have recently achieved strong results in text generation. However, their multi-step sampling leads to slow inference, limiting practical use. To address this, we extend Inverse Distillation, a technique…

Machine Learning · Computer Science 2026-02-24 David Li , Nikita Gushchin , Dmitry Abulkhanov , Eric Moulines , Ivan Oseledets , Maxim Panov , Alexander Korotin

Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because…

Machine Learning · Computer Science 2025-12-11 Amin Tavakoli , Raswanth Murugan , Ozan Gokdemir , Arvind Ramanathan , Frances Arnold , Anima Anandkumar

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Oriel Perets , Michal Linial , Nadav Rappoport

Large language models (LLMs) have demonstrated remarkable performance across a wide range of industrial applications, from search and recommendation systems to generative tasks. Although scaling laws indicate that larger models generally…

Large language models (LLMs) achieve remarkable performance through ever-increasing parameter counts, but scaling incurs steep computational costs. To better understand LLM scaling, we study representational differences between LLMs and…

Large language models have led to significant progress across many NLP tasks, although their massive sizes often incur substantial computational costs. Distillation has become a common practice to compress these large and highly capable…

Computation and Language · Computer Science 2026-01-06 Zishun Yu , Shangzhe Li , Xinhua Zhang

Inverse protein folding, the process of designing sequences that fold into a specific 3D structure, is crucial in bio-engineering and drug discovery. Traditional methods rely on experimentally resolved structures, but these cover only a…

Biomolecules · Quantitative Biology 2023-11-27 Igor Melnyk , Aurelie Lozano , Payel Das , Vijil Chenthamarakshan

Large Language Models (LLMs) have demonstrated remarkable performance across a wide range of natural language processing tasks. However, their enormous parameter size and extremely high requirements for compute power pose challenges for…

Computation and Language · Computer Science 2024-03-26 Bohao Yang , Chen Tang , Kun Zhao , Chenghao Xiao , Chenghua Lin

Previous studies have proved that cross-lingual knowledge distillation can significantly improve the performance of pre-trained models for cross-lingual similarity matching tasks. However, the student model needs to be large in this…

Computation and Language · Computer Science 2022-09-14 Kunbo Ding , Weijie Liu , Yuejian Fang , Zhe Zhao , Qi Ju , Xuefeng Yang

Proteins are fundamental to biology, executing diverse functions through complex physicochemical interactions, and they hold transformative potential across medicine, materials science, and environmental applications. Protein Language…

Biomolecules · Quantitative Biology 2025-06-11 Logan Hallee , Nikolaos Rafailidis , David B. Bichara , Jason P. Gleghorn

Specialized reasoning language models (RLMs) have demonstrated that scaling test-time computation through detailed reasoning traces significantly enhances performance. Although these traces effectively facilitate knowledge distillation into…

Computation and Language · Computer Science 2025-07-16 Philip Lippmann , Jie Yang

Pre-trained Language Models (PLMs) have been successful for a wide range of natural language processing (NLP) tasks. The state-of-the-art of PLMs, however, are extremely large to be used on edge devices. As a result, the topic of model…

Distilling large language models (LLMs) typically involves transferring the teacher model's responses through supervised fine-tuning (SFT). However, this approach neglects the potential to distill both data (output content) and reward…

Computation and Language · Computer Science 2025-02-28 Yudi Zhang , Lu Wang , Meng Fang , Yali Du , Chenghua Huang , Jun Wang , Qingwei Lin , Mykola Pechenizkiy , Dongmei Zhang , Saravan Rajmohan , Qi Zhang

In most natural language inference problems, sentence representation is needed for semantic retrieval tasks. In recent years, pre-trained large language models have been quite effective for computing such representations. These models…

Computation and Language · Computer Science 2023-04-26 Domagoj Ševerdija , Tomislav Prusina , Antonio Jovanović , Luka Borozan , Jurica Maltar , Domagoj Matijević

Large language models have driven significant progress in natural language processing, but their deployment requires substantial compute and memory resources. As models scale, compression techniques become essential for balancing model…

Machine Learning · Computer Science 2025-05-13 Vithursan Thangarasa , Ganesh Venkatesh , Mike Lasby , Nish Sinnadurai , Sean Lie

Protein language models (PLMs) have revolutionised computational biology through their ability to generate powerful sequence representations for diverse prediction tasks. However, their black-box nature limits biological interpretation and…

Biomolecules · Quantitative Biology 2025-04-11 Jan van Eck , Dea Gogishvili , Wilson Silva , Sanne Abeln

Today, transformer language models serve as a core component for majority of natural language processing tasks. Industrial application of such models requires minimization of computation time and memory footprint. Knowledge distillation is…

Computation and Language · Computer Science 2022-05-06 Alina Kolesnikova , Yuri Kuratov , Vasily Konovalov , Mikhail Burtsev
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