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Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Emmanuella Avwerosuoghene Oghenekaro

Recent multimodal deepfake detection methods designed for generalization conjecture that single-stage supervised training struggles to generalize across unseen manipulations and datasets. However, such approaches that target generalization…

Computer Vision and Pattern Recognition · Computer Science 2025-11-14 Ashutosh Anshul , Shreyas Gopal , Deepu Rajan , Eng Siong Chng

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Zhongyi Shui , Yunlong Zhang , Kai Yao , Chenglu Zhu , Sunyi Zheng , Jingxiong Li , Honglin Li , Yuxuan Sun , Ruizhe Guo , Lin Yang

Accurate and reliable nuclei identification is an essential part of quantification in microscopy. A range of mathematical and machine learning approaches are used but all methods have limitations. Such limitations include sensitivity to…

Quantitative Methods · Quantitative Biology 2019-04-11 Carl J. Nelson , Philip T. G. Jackson , Boguslaw Obara

Recent studies have demonstrated the superiority of deep learning in medical image analysis, especially in cell instance segmentation, a fundamental step for many biological studies. However, the excellent performance of the neural networks…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Huaqian Wu , Nicolas Souedet , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

Nucleus detection and classification (NDC) in histopathology analysis is a fundamental task that underpins a wide range of high-level pathology applications. However, existing methods heavily rely on labor-intensive nucleus-level…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Zijiang Yang , Hanqing Chao , Bokai Zhao , Yelin Yang , Yunshuo Zhang , Dongmei Fu , Junping Zhang , Le Lu , Ke Yan , Dakai Jin , Minfeng Xu , Yun Bian , Hui Jiang

Numerous phenomenological nuclear models have been proposed to describe specific observables within different regions of the nuclear chart. However, developing a unified model that describes the complex behavior of all nuclei remains an…

Nuclear Theory · Physics 2025-05-14 Jose M. Munoz , Silviu M. Udrescu , Ronald F. Garcia Ruiz

Accurate nuclei segmentation in histopathological images is crucial for cancer diagnosis. Automating this process offers valuable support to clinical experts, as manual annotation is time-consuming and prone to human errors. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-13 Ayush Roy , Payel Pramanik , Dmitrii Kaplun , Sergei Antonov , Ram Sarkar

Due to cellular heterogeneity, cell nuclei classification, segmentation, and detection from pathological images are challenging tasks. In the last few years, Deep Convolutional Neural Networks (DCNN) approaches have been shown…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Md Zahangir Alom , Chris Yakopcic , Tarek M. Taha , Vijayan K. Asari

The accuracy of deep learning methods for two foundational tasks in medical image analysis -- detection and segmentation -- can suffer from class imbalance. We propose a `switching loss' function that adaptively shifts the emphasis between…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Deepak Anand , Gaurav Patel , Yaman Dang , Amit Sethi

In computational pathology, nuclear instance segmentation is a fundamental task with many downstream clinical applications. With the advent of deep learning, many approaches, including convolutional neural networks (CNNs) and vision…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Amirreza Mahbod , Ramona Woitek , Jeanne Shen

Segmentation of nuclei regions from histological images enables morphometric analysis of nuclei structures, which in turn helps in the detection and diagnosis of diseases under consideration. To develop a nuclei segmentation algorithm,…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Suman Mahapatra , Pradipta Maji

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Volodymyr Sydorskyi , Igor Krashenyi , Oleksii Yakubenko

Pretraining CNN models (i.e., UNet) through self-supervision has become a powerful approach to facilitate medical image segmentation under low annotation regimes. Recent contrastive learning methods encourage similar global representations…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Zhangsihao Yang , Mengwei Ren , Kaize Ding , Guido Gerig , Yalin Wang

Computer-aided diagnosis (CAD) based on histopathological imaging has progressed rapidly in recent years with the rise of machine learning based methodologies. Traditional approaches consist of training a classification model using features…

Computer Vision and Pattern Recognition · Computer Science 2019-03-29 Junaid Malik , Serkan Kiranyaz , Suchitra Kunhoth , Turker Ince , Somaya Al-Maadeed , Ridha Hamila , Moncef Gabbouj

Follow-up serves an important role in the management of pulmonary nodules for lung cancer. Imaging diagnostic guidelines with expert consensus have been made to help radiologists make clinical decision for each patient. However, tumor…

Image and Video Processing · Electrical Eng. & Systems 2020-10-12 Yamin Li , Jiancheng Yang , Yi Xu , Jingwei Xu , Xiaodan Ye , Guangyu Tao , Xueqian Xie , Guixue Liu

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

The accurate segmentation of medical images is a crucial step in obtaining reliable morphological statistics. However, training a deep neural network for this task requires a large amount of labeled data to ensure high-accuracy results. To…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Xianjun Han , Qianqian Chen , Zhaoyang Xie , Xuejun Li , Hongyu Yang